Effects of efflux pump inhibitors phenyl-arginine-β-naphthylamide and 1-(1-naphthylmethyl)-piperazine on the antimicrobial susceptibility of Pseudomonas aeruginosa isolates from cystic fibrosis patients

Journal of Chemotherapy

Volumn 21, Issue 5, 2009, Pages 592-594

  Coban, Ahmet Yilmaz ^a   Tanriverdi Cayci, Y ^a   Erturan, Z ^b   Durupinar, B ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 NAPHTHYLMETHYL)PIPERAZINE; AMIDE; AZTREONAM; CEFEPIME; CEFTAZIDIME; CIPROFLOXACIN; GENTAMICIN; LEVOFLOXACIN; MEROPENEM; NAPHTHYL GROUP; PHENYLARGININE BETA NAPHTHYLAMIDE; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; PIPERAZINE; TOBRAMYCIN; UNCLASSIFIED DRUG; 1-(1-NAPHTHYLMETHYL)PIPERAZINE; ANTIINFECTIVE AGENT; DIPEPTIDE; PHENYLALANINE ARGININE BETA NAPHTHYLAMIDE; PHENYLALANINE ARGININE BETA-NAPHTHYLAMIDE; PIPERAZINE DERIVATIVE;

ACINETOBACTER; ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIUM ISOLATE; CAMPYLOBACTER JEJUNI; CYSTIC FIBROSIS; DRUG ACTIVITY; DRUG EFFECT; ENTEROBACTERIACEAE; ESCHERICHIA COLI; HUMAN; LETTER; NONHUMAN; PSEUDOMONAS AERUGINOSA; PUMP; VIBRIO CHOLERAE; COMPARATIVE STUDY; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PSEUDOMONAS INFECTION;

ANTI-BACTERIAL AGENTS; CYSTIC FIBROSIS; DIPEPTIDES; HUMANS; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 75549091972     PISSN: 1120009X     EISSN: 19739478     Source Type: Journal    
DOI: 10.1179/joc.2009.21.5.592     Document Type: Letter

References (14)

1. Koneman EW, Allen SD, Janda WM, Schreckenberger PC, Winn WC JR. Color Atlas and Textbook of Diagnostic Microbiology, Fifth edition 1997: 269.
2. CLSI. Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved standard-Ninth Edition. M2-A9, 2006.
3. Livermore DM, Winstanley TG, Shannon KP. Interpretative reading: recognizing the unusual and inferring resistance mechanism from resistance phenotypes. J Antimicrob Chemother 2001; 48, Suppl, S 1: 87-102.
4. Livermore DM. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: Our worst nightmare? Clin Infect Dis 2002; 34: 634-640.
5. Coban AY, Ekinci B, Durupinar B. A multidrug efflux pump inhibitor reduces fluoroquinolone resistance in Pseudomonas aeruginosa isolates. Chemotherapy 2004; 50: 22-26.
6. Lomovskaya O, Warren MS, Lee A, Galazzo J, Fronko R, Lee M. et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother 2001; 45: 105-116.
7. Cetinkaya E, Coban AY, Durupinar B. Investigation of the effect of efflux pump inhibitors to MIC values of ciprofloxacin in clinical isolates of Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii and Staphylococcus aureus. Mikro biyol Bul 2008; 42: 553-561.
8. Bohnert JA, Kern WV. Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps. Antimicrob Agents Chemother 2005; 49: 849-852.
9. Schumacher A, Steinke P, Bohnert JA, Akova M, Jonas D, Kern WV. Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli. J Antimiorob Chemother 2006; 57: 344-348.
10. Kern WV, Steinke P, Schumacher A, Schuster S, von Baum H, Bohnert JA. Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli. J Antimicrob Chemother 2006; 57: 339-343.
11. Bina XR, Philippart JA, Bina JE. Effect of the efflux pump inhibitors 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-β naphthylamide on antimicrobial susceptibility and virulence factor production in Vibrio cholerae. J Antimicrob Chemother 2009; 63: 103-108.
12. Pannek S, Higgins PG, Steinke P, Jonas D, Akova M, Bohnert JA, et al. Multidrug efflux inhibition in Acinetobacter baumanni: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl arginine b nophthylamide. J Antimicrob Chemother 2006; 57: 970-974.
13. Hannula M, Hanninen ML. Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli. J Med Microbiol 2008; 57: 851-855.
14. Bean DC, Wareham DW. Paradoxical effect of 1-(1-naphthylmethyl)- piperazine on resistance to tetracyclines in multidrug-resistant Acinetobacter baumannii. J Antimicrob Chemother 2009; 63: 349-352.