Neurotoxic effects of 25mg/kg/bodyweight of artemether on the histology of the trapezoid nuclei and behavioural functions in adult male Wistar rats

Acta Histochemica

Volumn 112, Issue 2, 2010, Pages 193-198

  Akinlolu, Abdulazeez Adelaja ^a   Shokunbi, Mathew Temitayo ^b  

^a OLABISI ONABANJO UNIVERSITY   (Nigeria)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Artemether; Behavioural functions; Brain weight; Neurotoxicity; Patchychromatic neurons; Trapezoid nuclei; Wistar rats

Indexed keywords

ARTEMETHER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY EQUILIBRIUM; BODY WEIGHT; BRAIN NUCLEUS; BRAIN STEM; BRAIN WEIGHT; CONTROLLED STUDY; COORDINATION; HISTOLOGY; MALE; NEUROTOXICITY; NONHUMAN; RAT;

ANIMALS; ANTIMALARIALS; ARTEMISININS; DRUG ADMINISTRATION SCHEDULE; GAIT; INJECTIONS, INTRAMUSCULAR; MALE; NEURONS; PONS; POSTURAL BALANCE; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 75549088641     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2008.09.006     Document Type: Article

References (21)

1. Adelaja A.A., Owoeye O., Ejiwunmi A.B. The neurotoxic effects of artemether on the cytoarchitecture of the trapezoid nuclei of adult male Wistar rats (Rattus norvegicus). Int J Morphol 2006, 24(4):535-540.
2. Nontprasert A., Pukrittayakamee S., Nosten-Bertrand M., Vanijanonta S., White N. Studies of the neurotoxicity of oral artemisinin derivatives in mice. Am J Trop Med Hyg 2000, 62(3):409-412.
3. Brewer T.G., Grate S.J., Peggins J.O., Weina P.J., Petras J.M., Levine B.S., et al. Fatal neurotoxicity of arteether and artemether. Am Trop Med J Hyg 1994, 51(3):252-259.
4. Brewer T.G., Peggins J.O., Grate S.J., Petras J.M., Levine B.S., Weina P.J., et al. Neurotoxicity in animals due to arteether and artemether. Trans R Soc Trop Med Hyg 1994, 88(Suppl 1):S33-S36.
5. Genovese R.F., Newman D.B., Li Q., Peggins J.O., Brewer T.G. Dose-dependent brainstem neuropathology following repeated arteether administration in rats. Brain Res Bull 1998, (45):199-202.
6. Gordi T., Lepist E.I. Artemisinin derivatives: toxic for laboratory animals, safe for humans? Toxicol Lett 2004, 147(2):99-107.
7. Klayman D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985, 228:1049-1055.
8. Li Q.G., Brewer T.G., Peggins J.O. Anorectic toxicity of dihydroartemisinin, artemether, and arteether in rats following multiple intramuscular doses. International Journal of Toxicology 1998, (17):663-676.
9. Li G.Q., Mog S.R., Si Y.Z., Kyle D.E., Gettayacamin M., Milhous Anw K. Neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents. Am J Trop Med Hyg 2002, 66(5):516-525.
10. Luo X.D., Bossi A., Flippen-Anderson J.L., Gillards R. The chemistry of drugs. Part IV. Configurations of antimalarials derived from Qinghaosu: dihydroqinghaosu, artemether and artesunic acid. Helv Chim Acta 1984, 67(6):1515-1522.
11. Soriano M.A., Ferer I., Rodriguez-Farre E., Planas A.M. Expression of c-fos and inducible hsp-70 mRNA following a transient episode of focal ischemia that had non-lethal effects on the rat brain. Brain Res 1995, 670:317-320.
12. Meneguz A., Fortuna S., Lorenzini P., Volpe M.T. Influence of urethane and ketamine on rat hepatic cytochrome P450 in vivo. Exp Toxicol Pathol 1999, 51(4-5):392-396.
13. Meshnick S.R. Artemisinin: mechanism of action, resistance and toxicity. Int J Parasitol 2002, 32:1655-1660.
14. Nontprasert A., Pukrittayakamee S., Nosten-Bertrand M., Vanijanonta S., White N.J. Studies of the neurotoxicity of oral artemisinin derivatives in mice. Am J Trop Med Hyg 2000, (62):409-412.
15. Gibbs R.A., Weinstock G.M., Metzker M.L., et al. (Rat genome sequencing project consortium). Genome sequence of the brown Norway rat yields insights into mammalian evolution. Nature 2004, 428:493-521.
16. Schmid G., Hofheinz W. Total synthesis of qinghaosu. J Am Chem Soc 1983, 195:624-625.
17. Shen JX editor. Antimalarial drug development in China. Beijing: National Institute of Pharmaceutical Research and Development; 1989; p. 31-95.
18. Shen JX, Li GQ. The history of the development of artemisinin derivatives for antimalarial chemotherapy in China, Hong Kong, Symposium, VII International Conference on Infectious Diseases; 1996; June 12.
19. Toovey S. Mechanisms of artemisinin combination therapy neurotoxicity. Ph.D. Thesis; Supervised by Prof. Dr. J. Vercruysse, Laboratorium voor Parasitologie Vakgroep Virologie, Parasitologie en Immunologie Faculteit Diergeneeskunde, Universiteit Gent.; 2006.
20. Van Vugt M., Angus B.J., Price R.N., et al. A case-control auditory evaluation of patients treated with artemisinin derivatives for multidrug-resistant Plasmodium falciparum malaria. Am J Trop Med Hyg 2000, 62(1):65-69.
21. West P. Neurosciences in medicine. J P Lincolt 1995, 9:214-224.