Hyperglycemia in diabetics and non-diabetics: Effect on the risk for and severity of pneumococcal pneumonia

Journal of Infection

Volumn 60, Issue 2, 2010, Pages 99-105

  Rueda, Adriana M ^a,b   Ormond, Mandy ^b   Gore, Meghana ^a   Matloobi, Mahsa ^a   Giordano, Thomas P ^a,b   Musher, Daniel M ^a,b  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Diabetes mellitus; Hyperglycemia; Pneumococcus; Pneumonia; Severity of disease

Indexed keywords

CYTOKINE; GLUCOCORTICOID; GLUCOSE; HEMOGLOBIN A1C;

ADULT; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DIABETES MELLITUS; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HIGH RISK PATIENT; HUMAN; HYPERGLYCEMIA; INFECTION RISK; MALE; MORTALITY; STREPTOCOCCUS PNEUMONIA;

AGED; DIABETES COMPLICATIONS; FEMALE; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED; PNEUMONIA, PNEUMOCOCCAL; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 75549085949     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2009.12.003     Document Type: Article

References (30)

1. Musher D.M. Streptococcus pneumoniae. Mandell, Douglass and Bennett's Principles and Practice of Infectious Diseases 2005, 2392-2411. Churchill Livingstone, Philadelphia. G.L. Mandell, J.E. Bennett, R. Dolin (Eds.).
2. Mowat A.G., Baum J. Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus. N Engl J Med 1980, 142:869-875.
3. Bagdade J.D., Stewart M., Walters E. Impaired granulocyte adherence. A reversible defect in host defense in patients with poorly controlled diabetes. Diabetes 1978, 27:677-681.
4. Alexiewicz J.M., Kumar D., Smogorzewski M., Klin M., Massry S.G. Polymorphonuclear leukocytes in non-insulin-dependent diabetes mellitus: abnormalities in metabolism and function. Ann Intern Med 1995, 123:919-924.
5. MacRury S.M., Gemmell C.G., Paterson K.R., MacCuish A.C. Changes in phagocytic function with glycaemic control in diabetic patients. J Clin Pathol 1989, 42:1143-1147.
6. Nielson C.P., Hindson D.A. Inhibition of polymorphonuclear leukocyte respiratory burst by elevated glucose concentrations in vitro. Diabetes 1989, 38:1031-1035.
7. Ortmeyer J., Mohsenin V. Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils. Life Sci 1996, 59:255-262.
8. Nolan C.M., Beaty H.N., Bagdade J.D. Further characterization of the impaired bactericidal function of granulocytes in patients with poorly controlled diabetes. Diabetes 1978, 27:889-894.
9. Repine J.E., Clawson C.C., Goetz F.C. Bactericidal function of neutrophils from patients with acute bacterial infections and from diabetics. J Infect Dis 1980, 6:869-875.
10. Li Y.M., Tan A.X., Vlassara H. Antibacterial activity of lysozyme and lactoferrin is inhibited by binding of advanced glycation-modified proteins to a conserved motif. Nat Med 1995, 1:1057-1061.
11. Lipsky B.A., Boyko E.J., Inui T.S., Koepsell T.D. Risk factors for acquiring pneumococcal infections. Arch Intern Med 1986, 146:2179-2185.
12. Watanakunakorn C., Bailey T.A. Adult bacteremic pneumococcal pneumonia in a community teaching hospital, 1992-1996. A detailed analysis of 108 cases. Arch Intern Med 1997, 157:1965-1971.
13. Rahav G., Toledano Y., Engelhard D., Simhon A., Moses A.E., Sacks T., et al. Invasive pneumococcal infections: a comparison between adults and children. Medicine (Baltimore) 1997, 76:295-303.
14. Musher D.M., Alexandraki I., Graviss E.A., Yanbeiy N., Eid A., Inderias L.A., et al. Bacteremic and nonbacteremic pneumococcal pneumonia. A prospective study. Medicine (Baltimore) 2000, 79:210-221.
15. Falguera M., Pifarre R., Martin A., Sheikh A., Moreno A. Etiology and outcome of community-acquired pneumonia in patients with diabetes mellitus. Chest 2005, 128:3233-3239.
16. Kornum J.B., Thomsen R.W., Riis A., Lervang H.H., Schonheyder H.C., Sorensen H.T. Diabetes, glycemic control, and risk of hospitalization with pneumonia: a population-based case-control study. Diabetes Care 2008, 31:1541-1545.
17. Baker E.H., Janaway C.H., Philips B.J., Brennan A.L., Baines D.L., Wood D.M., et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax 2006, 61:284-289.
18. Marik P.E., Raghavan M. Stress-hyperglycemia, insulin and immunomodulation in sepsis. Intensive Care Med 2004, 30:748-756.
19. Baker E.H., Wood D.M., Brennan A.L., Clark N., Baines D.L., Philips B.J. Hyperglycemia and pulmonary infection. Proc Nutr Soc 2006, 65:227-235.
20. Gearhart M.M., Parbhoo S.K. Hyperglycemia in the critically ill patient. AACN Clin Issues 2006, 17:50-55.
21. Musher D.M., Rueda-Jaimes A.M., Graviss E.A., Rodriguez-Barradas M.C. Effect of pneumococcal vaccination: a comparison of vaccination rates in patients with bacteremic and nonbacteremic pneumococcal pneumonia. Clin Infect Dis 2006, 43:1004-1008.
22. Charles P.G., Wolfe R., Whitby M., Fine M.J., Fuller A.J., Stirling R., et al. SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia. Clin Infect Dis 2008, 47:375-384.
23. Chalmers J.D., Singanayagam A., Hill A.T. Predicting the need for mechanical ventilation and/or inotropic support for young adults admitted to the hospital with community-acquired pneumonia. Clin Infect Dis 2008, 47:1571-1574.
24. American Diabetes Association Standards of medical care in diabetes - 2009. Diabetes Care January 2009, 32(Suppl. 1):S13-S61.
25. Umpierrez G.E., Isaacs S.D., Bazargan N., You X., Thaler L.M., Kitabchi A.E. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 2002, 87:978-982.
26. McAlister F.A., Majumdar S.R., Blitz S., Rowe B.H., Romney J., Marrie T.J. The relation between hyperglycemia and outcomes in 2471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care 2005, 28:810-815.
27. Thomsen R.W., Hundborg H.H., Lervang H.H., Johnsen S.P., Schonheyder H.C., Sorensen H.T. Risk of community-acquired pneumococcal bacteremia in patients with diabetes: a population-based case-control study. Diabetes Care 2004, 27:1143-1147.
28. Benfield T., Jensen J.S., Nordestgaard B.G. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia 2007, 50:549-554.
29. Fine M.J., Smith M.A., Carson C.A., Mutha S.S., Sankey S.S., Weissfeld L.A., et al. Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA 1996, 275:134-141.
30. Finfer S., Chittock D.R., Su S.Y., Blair D., Foster D., Dhingra V., et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009, 360:1283-1297.