ExoU modulates soluble and membrane-bound ICAM-1 in Pseudomonas aeruginosa-infected endothelial cells

Microbes and Infection

Volumn 12, Issue 2, 2010, Pages 154-161

  Lins, Renata Ximenes ^a   de Assis, Maria Cristina ^a   Mallet de Lima, Carolina Diettrich ^a   Freitas, Carla ^a   Maciel Plotkowski, Maria Cristina ^a   Saliba, Alessandra Mattos ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

ExoU; ICAM 1; Inflammation; Pseudomonas aeruginosa; Type III secretion system

Indexed keywords

BACTERIAL TOXIN; CYTOTOXIN; EXOU PROTEIN; ICOSANOID; INTERCELLULAR ADHESION MOLECULE 1; MEMBRANE BOUND INTERCELLULAR ADHESION MOLECULE 1; PHOSPHOLIPASE A2; PROSTAGLANDIN SYNTHASE; SOLUBLE INTERCELLULAR ADHESION MOLECULE 1; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HOST CELL; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; TYPE III SECRETION SYSTEM; UPREGULATION;

BACTERIAL PROTEINS; CELL LINE; CYCLOOXYGENASE 2; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCIDINS; LIPOXYGENASE; PSEUDOMONAS AERUGINOSA;

PSEUDOMONAS AERUGINOSA;

EID: 75449113819     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2009.11.005     Document Type: Article

References (28)

1. Wolfgang M.C., Kulasekara B.R., Liang X., Boyd D., Wu K., Yang Q., Miyada C.G., and Lory S. Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 100 (2003) 8484-8489
2. Sato H., Frank D.W., Hillard C.J., Felix J.B., Pankhaniya R.R., Moriyama K., Finck-Barbançon V., Buchaklian A., Lei M., Long R.M., Wiener-Kronish J., and Sawa T. The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J. 22 (2003) 2959-2969
3. Saliba A.M., Nascimento D.O., Silva M.C.A., Assis M.C., Gayer C.R.M., Raymond B., Coelho M.G.P., Marques E.A., Touqui L., Albano L.R.M., Lopes U.G., Paiva D.D., Bozza P.T., and Plotkowski M.C. Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU. Cell. Microbiol. 7 (2005) 1811-1822
4. Berthelot P., Attree I., Plesiat P., Chabert J., de Bentzmann S., Pozzetto B., and Grattard F. Genotypic and phenotypic analysis of the type III secretion system in a cohort of Pseudomonas aeruginosa bacteremia isolates: evidence for a possible association between O serotypes and exo genes. J. Infect. Dis. 188 (2003) 512-518
5. Wareham D.W., and Curtis M.A. A genotypic and phenotypic comparison of type III secretion profiles of Pseudomonas aeruginosa cystic fibrosis and bacteremia isolates. Int. J. Med. Microbiol. 297 (2007) 227-234
6. Plotkowski M.C., Brandão B.A., Assis M.C., Feliciano L.F., Raymond B., Freitas C., Saliba A.M., Zahm J.M., Touqui L., and Bozza P.T. Lipid body mobilization in the ExoU-induced release of inflammatory mediators by airway epithelial cells. Microb. Pathog. 45 (2008) 30-37
7. Ley K., Laudanna C., Cybulsky M.I., and Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 7 (2007) 678-689
8. Borgatti M., Bezzerri V., Mancini I., Nicolis E., Dechecchi M.C., Lampronti I., Rizzotti P., Cabrini G., and Gambari R. Induction of IL-6 gene expression in a CF bronchial epithelial cell line by Pseudomonas aeruginosa is dependent on transcription factors belonging to the Sp1 superfamily. Biochem. Biophys. Res. Commun. 357 (2007) 977-983
9. Witkowska A.M., and Borawska M.H. Soluble intercellular adhesion molecule-1 (sICAM-1): an overview. Eur. Cytokine Netw. 15 (2004) 91-98
10. Kayal S., Jaïs J.-P., Aguini N., Chaudière J., and Labrousse J. Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection. Am. J. Respir. Crit. Care Med. 157 (1998) 776-784
11. Gando S., Kameue T., Matsuda N., Hayakawa M., Hoshino H., and Kato H. Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation. Thromb. Res. 116 (2005) 91-100
12. Hsu H.-Y., Wittemann S., Schneider E.M., Weiss M., and Joos T.O. Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases. Med. Eng. Phys. 30 (2008) 976-983
13. Ades E.W., Candal F.J., Swerlick R.A., Summers G.V.G., Bosse D.C., and Lawley T.J. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J. Invest. Dermatol. 99 (1992) 683-690
14. Saliba A.M., Assis M.C., Nishi R., Raymond B., Marques E.A., Lopes U.G., Touqui L., and Plotkowski M.C. Implications of oxidative stress in the cytotoxicity of Pseudomonas aeruginosa ExoU. Microbes Infect. 8 (2006) 450-459
15. Rabin S.D.P., and Hauser A.R. Functional regions of the Pseudomonas aeruginosa cytotoxin ExoU. Infect. Immun. 73 (2005) 573-582
16. Wakatsuki T., Kimura K., Kimura F., Shinomiya N., Ohtsubo M., Ishizawa M., and Yamamoto M. A distinct mRNA encoding a soluble form of ICAM-1 molecule expressed in human tissues. Cell. Adhes. Commun. 3 (1995) 283-292
17. Bishop-Bailey D., Burke-Gaffney A., Hellewell P.G., Pepper J.R., and Mitchell J.A. Cyclo-oxygenase-2 regulates inducible ICAM-1 and VCAM-1 expression in human vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 249 (1998) 44-47
18. Kapiotis S., Sengoelge G., Sperr W.R., Baghestanian M., Quehenberger P., Bevec D., Li S.R., Menzel E.J., Mühl A., Zapolska D., Virgolini I., Valent P., and Speiser W. Ibuprofen inhibits pyrogen-dependent expression of VCAM-1 and ICAM-1 on human endothelial cells. Life Sci. 58 (1996) 2167-2181
19. Seok S.M., Park D.H., Kim Y.C., Moon C.H., Jung Y.S., Baik E.J., Moon C.K., and Lee S.H. COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells. Toxicol. Lett. 165 (2006) 212-220
20. Sadikot R.T., Zeng H., Azim A.C., Joo M., Dey S.K., Breyer R.M., Peebles R.S., Blackwell T.S., and Christman J.W. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur. J. Immunol. 37 (2007) 1001-1009
21. Diaz M.H., Shaver C.M., King J.D., Musunuri S., Kazzaz J.A., and Hause A.R. Pseudomonas aeruginosa induces localized immunosuppression during pneumonia. Infect. Immun. 76 (2008) 4414-4421
22. Greene C.M., Carroll T.P., Smith S.G.J., Taggart C.C., Devaney J., Griffin S., O'Neill S.J., and McElvaney N.G. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J. Immunol. 174 (2005) 1638-1646
23. Look D.C., Stoll L.L., Romig S.A., Humlicek A., Britigan B.E., and Denning G.M. Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms. J. Immunol. 175 (2005) 4017-4023
24. Perfetto B., Donnarumma G., Criscuolo D., Paoletti I., Grimaldi E., Tufano M.A., and Baroni A. Bacterial components induce cytokine and intercellular adhesion molecules-1 and activate transcription factors in dermal fibroblasts. Res. Microbiol. 154 (2003) 337-344
25. Schmal H., Czermak B.J., Lentsch A.B., Bless N.M., Beck-Schimmer B., Friedl H.P., and Ward P.A. Soluble ICAM-1 activates lung macrophages and enhances lung injury. J. Immunol. 161 (1998) 3685-3693
26. Hein O.V., Misterek K., Tessmann J.P., van Dossow V., Krimphove M., and Spies C. Time course of endothelial damage in septic shock: prediction of outcome. Crit. Care 9 (2005) R323-R330
27. De Rose V., Oliva A., Messore B., Grosso B., Mollar C., and Pozzi E. Circulating adhesion molecules in cystic fibrosis. Am. J. Respir. Crit. Care Med. 157 (1998) 1234-1239
28. Grenier D., and Bodet C. Streptococcus suis stimulates ICAM-1 shedding from microvascular endothelial cells. FEMS Immunol. Med. Microbiol. 54 (2008) 271-276