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Volumn 26, Issue 1, 2010, Pages 59-70

Role of PKCζ translocation in the development of type 2 diabetes in rats following continuous glucose infusion

Author keywords

Insulin resistance; Phosphatidylinositol dependent kinase 1; Protein kinase B; Protein kinase C ; Translocation; Type 2 diabetes

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN KINASE C ZETA; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE;

EID: 75449102371     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1056     Document Type: Article
Times cited : (7)

References (49)
  • 1
    • 0033595121 scopus 로고    scopus 로고
    • Glucose transporters and insulin action - implications for insulin resistance and diabetes mellitus
    • Shepherd PR, Kahn BB. Glucose transporters and insulin action - implications for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341: 248-257.
    • (1999) N Engl J Med , vol.341 , pp. 248-257
    • Shepherd, P.R.1    Kahn, B.B.2
  • 2
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 1981; 30: 1000-1007.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 3
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
    • Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 1988; 255: E769-774.
    • (1988) Am J Physiol , vol.255
    • Baron, A.D.1    Brechtel, G.2    Wallace, P.3    Edelman, S.V.4
  • 4
    • 0033593461 scopus 로고    scopus 로고
    • Signaling mechanisms that regulate glucose transport
    • Czech MP, Corvera S. Signaling mechanisms that regulate glucose transport. J Biol Chem 1999; 274: 1865-1868.
    • (1999) J Biol Chem , vol.274 , pp. 1865-1868
    • Czech, M.P.1    Corvera, S.2
  • 5
    • 0030034311 scopus 로고    scopus 로고
    • Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber. In search of GLUT4 trafficking pathways
    • ZorzanoA, Munoz P, CampsM, MoraC, Testar X, PalacinM. Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber. In search of GLUT4 trafficking pathways. Diabetes 1996; 45: S70-81.
    • (1996) Diabetes , vol.45
    • Zorzano, A.1    Munoz, P.2    Camps, M.3    Mora, C.4    Testar, X.5    Palacin, M.6
  • 6
    • 0032104120 scopus 로고    scopus 로고
    • Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
    • Garvey WT, Maianu L, Zhu JH, Brechtel-Hook G, Wallace P, Baron AD. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest 1998; 101: 2377-2386.
    • (1998) J Clin Invest , vol.101 , pp. 2377-2386
    • Garvey, W.T.1    Maianu, L.2    Zhu, J.H.3    Brechtel-Hook, G.4    Wallace, P.5    Baron, A.D.6
  • 7
    • 0034070580 scopus 로고    scopus 로고
    • Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients
    • Ryder JW, Yang J, Galuska D, et al. Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients. Diabetes 2000; 49: 647-654.
    • (2000) Diabetes , vol.49 , pp. 647-654
    • Ryder, J.W.1    Yang, J.2    Galuska, D.3
  • 8
    • 0026660653 scopus 로고
    • Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation
    • Backer JM, Myers MG Jr, Shoelson SE, et al. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. Embo J 1992; 11: 3469-3479.
    • (1992) Embo J , vol.11 , pp. 3469-3479
    • Backer, J.M.1    Myers Jr, M.G.2    Shoelson, S.E.3
  • 9
    • 0033913213 scopus 로고    scopus 로고
    • Signaling pathways in insulin action: Molecular targets of insulin resistance
    • Pessin JE, Saltiel AR. Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest 2000; 106: 165-169.
    • (2000) J Clin Invest , vol.106 , pp. 165-169
    • Pessin, J.E.1    Saltiel, A.R.2
  • 10
    • 0029973135 scopus 로고    scopus 로고
    • Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
    • Martin SS, Haruta T, Morris AJ, Klippel A, Williams LT, Olefsky JM. Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem 1996; 271: 17605-17608.
    • (1996) J Biol Chem , vol.271 , pp. 17605-17608
    • Martin, S.S.1    Haruta, T.2    Morris, A.J.3    Klippel, A.4    Williams, L.T.5    Olefsky, J.M.6
  • 11
    • 0033049422 scopus 로고    scopus 로고
    • Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
    • Wang Q, Somwar R, Bilan PJ, et al. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 1999; 19: 4008-4018.
    • (1999) Mol Cell Biol , vol.19 , pp. 4008-4018
    • Wang, Q.1    Somwar, R.2    Bilan, P.J.3
  • 12
    • 0031038052 scopus 로고    scopus 로고
    • Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport
    • Bandyopadhyay G, Standaert ML, Zhao L, et al. Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. J Biol Chem 1997; 272: 2551-2558.
    • (1997) J Biol Chem , vol.272 , pp. 2551-2558
    • Bandyopadhyay, G.1    Standaert, M.L.2    Zhao, L.3
  • 13
    • 0036142812 scopus 로고    scopus 로고
    • Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation
    • Kralik SF, Liu P, Leffler BJ, Elmendorf JS. Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. Endocrinology 2002; 143: 37-46.
    • (2002) Endocrinology , vol.143 , pp. 37-46
    • Kralik, S.F.1    Liu, P.2    Leffler, B.J.3    Elmendorf, J.S.4
  • 14
    • 0030808673 scopus 로고    scopus 로고
    • Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway
    • Chen D, Elmendorf JS, Olson AL, Li X, Earp HS, Pessin JE. Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway. J Biol Chem 1997; 272: 27401-27410.
    • (1997) J Biol Chem , vol.272 , pp. 27401-27410
    • Chen, D.1    Elmendorf, J.S.2    Olson, A.L.3    Li, X.4    Earp, H.S.5    Pessin, J.E.6
  • 15
    • 0023198901 scopus 로고
    • Hyperglycemia decreases glucose uptake in type I diabetes
    • Yki-Jarvinen H, Helve E, Koivisto VA. Hyperglycemia decreases glucose uptake in type I diabetes. Diabetes 1987; 36: 892-896.
    • (1987) Diabetes , vol.36 , pp. 892-896
    • Yki-Jarvinen, H.1    Helve, E.2    Koivisto, V.A.3
  • 16
    • 0028204464 scopus 로고
    • Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: In vitro reversal of muscular insulin resistance
    • Zierath JR, Galuska D, Nolte LA, Thorne A, Kristensen JS, Wallberg-Henriksson H. Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: in vitro reversal of muscular insulin resistance. Diabetologia 1994; 37: 270-277.
    • (1994) Diabetologia , vol.37 , pp. 270-277
    • Zierath, J.R.1    Galuska, D.2    Nolte, L.A.3    Thorne, A.4    Kristensen, J.S.5    Wallberg-Henriksson, H.6
  • 17
    • 0030827388 scopus 로고    scopus 로고
    • Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats
    • Krook A, Kawano Y, Song XM, et al. Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats. Diabetes 1997; 46: 2110-2114.
    • (1997) Diabetes , vol.46 , pp. 2110-2114
    • Krook, A.1    Kawano, Y.2    Song, X.M.3
  • 18
    • 0034015147 scopus 로고    scopus 로고
    • Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats
    • Nawano M, Oku A, Ueta K, et al. Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats. Am J Physiol Endocrinol Metab 2000; 278: E535-543.
    • (2000) Am J Physiol Endocrinol Metab , vol.278
    • Nawano, M.1    Oku, A.2    Ueta, K.3
  • 19
    • 0033539950 scopus 로고    scopus 로고
    • Hyperglycemia impairs the insulin signaling step between PI 3-kinase and Akt/PKB activations in ZDF rat liver
    • Nawano M, Ueta K, Oku A, et al. Hyperglycemia impairs the insulin signaling step between PI 3-kinase and Akt/PKB activations in ZDF rat liver. Biochem Biophys Res Commun 1999; 266: 252-256.
    • (1999) Biochem Biophys Res Commun , vol.266 , pp. 252-256
    • Nawano, M.1    Ueta, K.2    Oku, A.3
  • 20
    • 0033009465 scopus 로고    scopus 로고
    • Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle
    • Kurowski TG, Lin Y, Luo Z, et al. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes 1999; 48: 658-663.
    • (1999) Diabetes , vol.48 , pp. 658-663
    • Kurowski, T.G.1    Lin, Y.2    Luo, Z.3
  • 21
    • 0005828771 scopus 로고    scopus 로고
    • Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats
    • Song XM, Kawano Y, Krook A, et al. Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats. Diabetes 1999; 48: 664-670.
    • (1999) Diabetes , vol.48 , pp. 664-670
    • Song, X.M.1    Kawano, Y.2    Krook, A.3
  • 22
    • 0030748460 scopus 로고    scopus 로고
    • Insulin resistance due to hyperglycaemia: An adaptation protecting insulin-sensitive tissues
    • Yki-Jarvinen H, Makimattila S. Insulin resistance due to hyperglycaemia: an adaptation protecting insulin-sensitive tissues. Diabetologia 1997; 40: S141-144.
    • (1997) Diabetologia , vol.40
    • Yki-Jarvinen, H.1    Makimattila, S.2
  • 23
    • 0029042566 scopus 로고
    • Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle
    • Galante P, Mosthaf L, Kellerer M, et al. Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle. Diabetes 1995; 44: 646-651.
    • (1995) Diabetes , vol.44 , pp. 646-651
    • Galante, P.1    Mosthaf, L.2    Kellerer, M.3
  • 24
    • 0028031151 scopus 로고
    • Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase
    • Berti L, Mosthaf L, Kroder G, et al. Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase. J Biol Chem 1994; 269: 3381-3386.
    • (1994) J Biol Chem , vol.269 , pp. 3381-3386
    • Berti, L.1    Mosthaf, L.2    Kroder, G.3
  • 26
    • 0023594954 scopus 로고
    • Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo glucose infusions
    • Leahy JL, Cooper HE, Weir GC. Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo glucose infusions. Diabetes 1987; 36: 459-464.
    • (1987) Diabetes , vol.36 , pp. 459-464
    • Leahy, J.L.1    Cooper, H.E.2    Weir, G.C.3
  • 27
    • 0031886826 scopus 로고    scopus 로고
    • Effect of forty-eighthour glucose infusion into rats on islet ion fluxes, ATP/ADP ratio and redox ratios of pyridine nucleotides
    • Ammon HP, Bacher M, Brandle WF, et al. Effect of forty-eighthour glucose infusion into rats on islet ion fluxes, ATP/ADP ratio and redox ratios of pyridine nucleotides. J Endocrinol 1998; 156: 583-590.
    • (1998) J Endocrinol , vol.156 , pp. 583-590
    • Ammon, H.P.1    Bacher, M.2    Brandle, W.F.3
  • 28
    • 0036203155 scopus 로고    scopus 로고
    • Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle
    • HoudaliB, NguyenV, AmmonHP, et al. Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle. Diabetologia 2002; 45: 356-368.
    • (2002) Diabetologia , vol.45 , pp. 356-368
    • HoudaliB1    NguyenV2    AmmonHP3
  • 29
    • 0025721929 scopus 로고
    • Effect of diffusion distance on measurement of rat skeletal muscle glucose transport in vitro
    • Henriksen EJ, Holloszy JO. Effect of diffusion distance on measurement of rat skeletal muscle glucose transport in vitro. Acta Physiol Scand 1991; 143: 381-386.
    • (1991) Acta Physiol Scand , vol.143 , pp. 381-386
    • Henriksen, E.J.1    Holloszy, J.O.2
  • 30
    • 0023024150 scopus 로고
    • Activation of glucose transport in muscle by prolonged exposure to insulin. Effects of glucose and insulin concentrations
    • Young DA, Uhl JJ, Cartee GD, Holloszy JO. Activation of glucose transport in muscle by prolonged exposure to insulin. Effects of glucose and insulin concentrations. J Biol Chem 1986; 261: 16049-16053.
    • (1986) J Biol Chem , vol.261 , pp. 16049-16053
    • Young, D.A.1    Uhl, J.J.2    Cartee, G.D.3    Holloszy, J.O.4
  • 31
    • 0033861608 scopus 로고    scopus 로고
    • Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity
    • Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL. Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 2000; 49: 1353-1358.
    • (2000) Diabetes , vol.49 , pp. 1353-1358
    • Itani, S.I.1    Zhou, Q.2    Pories, W.J.3    MacDonald, K.G.4    Dohm, G.L.5
  • 32
    • 0031984952 scopus 로고    scopus 로고
    • Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
    • Anai M, Funaki M, Ogihara T, et al. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes 1998; 47: 13-23.
    • (1998) Diabetes , vol.47 , pp. 13-23
    • Anai, M.1    Funaki, M.2    Ogihara, T.3
  • 33
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi DR, James SR, Downes CP, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997; 7: 261-269.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3
  • 34
    • 0030810216 scopus 로고    scopus 로고
    • Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
    • StandaertML, Galloway L, Karnam P, Bandyopadhyay G, Moscat J, Farese RV. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. J BiolChem1997; 272: 30075-30082.
    • (1997) J BiolChem , vol.272 , pp. 30075-30082
    • Standaert, M.L.1    Galloway, L.2    Karnam, P.3    Bandyopadhyay, G.4    Moscat, J.5    Farese, R.V.6
  • 35
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • Davis BJ, Xie Z, Viollet B, Zou MH. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 2006; 55: 496-505.
    • (2006) Diabetes , vol.55 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3    Zou, M.H.4
  • 36
    • 0025143220 scopus 로고
    • Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin- and exerciserecruitable transporter pools in skeletal muscle
    • Douen AG, Ramlal T, Rastogi S, et al. Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin- and exerciserecruitable transporter pools in skeletal muscle. J Biol Chem 1990; 265: 13427-13430.
    • (1990) J Biol Chem , vol.265 , pp. 13427-13430
    • Douen, A.G.1    Ramlal, T.2    Rastogi, S.3
  • 37
    • 0025847218 scopus 로고
    • Insulin resistance in normal rats infused with glucose for 72 h
    • Hager SR, Jochen AL, Kalkhoff RK. Insulin resistance in normal rats infused with glucose for 72 h. Am J Physiol 1991; 260: E353-362.
    • (1991) Am J Physiol , vol.260
    • Hager, S.R.1    Jochen, A.L.2    Kalkhoff, R.K.3
  • 38
    • 0033399406 scopus 로고    scopus 로고
    • Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucoseinfused rat
    • Laybutt DR, Schmitz-Peiffer C, Saha AK, Ruderman NB, Biden TJ, Kraegen EW. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucoseinfused rat. Am J Physiol 1999; 277: E1070-1076.
    • (1999) Am J Physiol , vol.277
    • Laybutt, D.R.1    Schmitz-Peiffer, C.2    Saha, A.K.3    Ruderman, N.B.4    Biden, T.J.5    Kraegen, E.W.6
  • 39
    • 33745359912 scopus 로고    scopus 로고
    • Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats
    • Laybutt DR, Chisholm DJ, Kraegen EW. Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats. Am J Physiol 1997; 273: E1-9.
    • (1997) Am J Physiol , vol.273
    • Laybutt, D.R.1    Chisholm, D.J.2    Kraegen, E.W.3
  • 40
    • 0028799420 scopus 로고
    • Molecular cloning and characterization of a new member of the RAC protein kinase family: Association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins
    • KonishiH, Kuroda S, TanakaM, et al. Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Biochem Biophys Res Commun 1995; 216: 526-534.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 526-534
    • Konishi, H.1    Kuroda, S.2    Tanaka, M.3
  • 41
    • 0035012128 scopus 로고    scopus 로고
    • Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle
    • Oku A, Nawano M, Ueta K, et al. Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle. Am J Physiol Endocrinol Metab 2001; 280: E816-824.
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Oku, A.1    Nawano, M.2    Ueta, K.3
  • 42
    • 0028107407 scopus 로고
    • Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats
    • Leahy JL, Bumbalo LM, Chen C. Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats. Diabetes 1994; 43: 173-179.
    • (1994) Diabetes , vol.43 , pp. 173-179
    • Leahy, J.L.1    Bumbalo, L.M.2    Chen, C.3
  • 43
    • 0038825044 scopus 로고    scopus 로고
    • Glucotoxicity and beta-cell failure in type 2 diabetes mellitus
    • Kaiser N, Leibowitz G, Nesher R. Glucotoxicity and beta-cell failure in type 2 diabetes mellitus. J Pediatr Endocrinol Metab 2003; 16: 5-22.
    • (2003) J Pediatr Endocrinol Metab , vol.16 , pp. 5-22
    • Kaiser, N.1    Leibowitz, G.2    Nesher, R.3
  • 44
    • 0033034807 scopus 로고    scopus 로고
    • Hyperglycemiainduced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
    • DonathMY, GrossDJ, CerasiE, KaiserN. Hyperglycemiainduced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 1999; 48: 738-744.
    • (1999) Diabetes , vol.48 , pp. 738-744
    • DonathMY1    GrossDJ2    CerasiE3    KaiserN4
  • 45
    • 0344394280 scopus 로고    scopus 로고
    • Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats
    • Steiler TL, Galuska D, Leng Y, Chibalin AV, Gilbert M, Zierath JR. Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. Endocrinology 2003; 144: 5259-5267.
    • (2003) Endocrinology , vol.144 , pp. 5259-5267
    • Steiler, T.L.1    Galuska, D.2    Leng, Y.3    Chibalin, A.V.4    Gilbert, M.5    Zierath, J.R.6
  • 46
    • 0033578776 scopus 로고    scopus 로고
    • 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide- dependent protein kinase-1
    • Jensen CJ, Buch MB, Krag TO, Hemmings BA, Gammeltoft S, Frodin M. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide- dependent protein kinase-1. J Biol Chem 1999; 274: 27168-27176.
    • (1999) J Biol Chem , vol.274 , pp. 27168-27176
    • Jensen, C.J.1    Buch, M.B.2    Krag, T.O.3    Hemmings, B.A.4    Gammeltoft, S.5    Frodin, M.6
  • 47
    • 0030799706 scopus 로고    scopus 로고
    • Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
    • Stokoe D, Stephens LR, Copeland T, et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 1997; 277: 567-570.
    • (1997) Science , vol.277 , pp. 567-570
    • Stokoe, D.1    Stephens, L.R.2    Copeland, T.3
  • 48
    • 0037064020 scopus 로고    scopus 로고
    • Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes
    • Egawa K, Maegawa H, Shi K, et al. Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes. J Biol Chem 2002; 277: 38863-38869.
    • (2002) J Biol Chem , vol.277 , pp. 38863-38869
    • Egawa, K.1    Maegawa, H.2    Shi, K.3
  • 49
    • 0001613219 scopus 로고
    • Protein kinase C zeta subspecies from rat brain: Its structure, expression, and properties
    • Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K, Nishizuka Y. Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Proc Natl Acad Sci USA 1989; 86: 3099-3103.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 3099-3103
    • Ono, Y.1    Fujii, T.2    Ogita, K.3    Kikkawa, U.4    Igarashi, K.5    Nishizuka, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.