-
2
-
-
0035933772
-
Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity
-
Keifer JA, Guttridge DC, Ashburner BP, et al. Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem 2001;276:22382-22387.
-
(2001)
J Biol Chem
, vol.276
, pp. 22382-22387
-
-
Keifer, J.A.1
Guttridge, D.C.2
Ashburner, B.P.3
-
3
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
Mitsiades N, Mitsiades CS, Poulaki V, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications. Blood 2002;99:4525-4530.
-
(2002)
Blood
, vol.99
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
4
-
-
0035412366
-
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
-
Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001;98:210-216.
-
(2001)
Blood
, vol.98
, pp. 210-216
-
-
Davies, F.E.1
Raje, N.2
Hideshima, T.3
-
5
-
-
36849024949
-
Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the antitumour activity of rituximab in vivo
-
Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, Roth M, Vaughn M, Knight J, Wallace P, Czuczman MS. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the antitumour activity of rituximab in vivo. Br J Haematol 2008;140:36-45.
-
(2008)
Br J Haematol
, vol.140
, pp. 36-45
-
-
Reddy, N.1
Hernandez-Ilizaliturri, F.J.2
Deeb, G.3
Roth, M.4
Vaughn, M.5
Knight, J.6
Wallace, P.7
Czuczman, M.S.8
-
6
-
-
0033168605
-
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha
-
Corral LG, Haslett PA, Muller GW, et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. J Immunol 1999;163:380-386.
-
(1999)
J Immunol
, vol.163
, pp. 380-386
-
-
Corral, L.G.1
Haslett, P.A.2
Muller, G.W.3
-
7
-
-
0032100486
-
Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD81 subset
-
Haslett PA, Corral LG, Albert M, et al. Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD81 subset. J Exp Med 1998;187:1885-1892.
-
(1998)
J Exp Med
, vol.187
, pp. 1885-1892
-
-
Haslett, P.A.1
Corral, L.G.2
Albert, M.3
-
8
-
-
33645736007
-
Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU. 1
-
Anderson G, Gries M, Kurihara N, et al. Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU. 1. Blood 2006;107: 3098-3105.
-
(2006)
Blood
, vol.107
, pp. 3098-3105
-
-
Anderson, G.1
Gries, M.2
Kurihara, N.3
-
9
-
-
18544390035
-
Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis
-
Koh KR, Janz M, Mapara MY, et al. Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis. Blood 2005;105:3833-3840.
-
(2005)
Blood
, vol.105
, pp. 3833-3840
-
-
Koh, K.R.1
Janz, M.2
Mapara, M.Y.3
-
10
-
-
0037262242
-
Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo
-
Lentzsch S, LeBlanc R, Podar K, et al. Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo. Leukemia 2003;17:41-44.
-
(2003)
Leukemia
, vol.17
, pp. 41-44
-
-
Lentzsch, S.1
LeBlanc, R.2
Podar, K.3
-
11
-
-
0035211277
-
Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma
-
D'Amato RJ, Lentzsch S, Anderson KC, et al. Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma. Semin Oncol 2001;28:597-601.
-
(2001)
Semin Oncol
, vol.28
, pp. 597-601
-
-
D'Amato, R.J.1
Lentzsch, S.2
Anderson, K.C.3
-
12
-
-
75449087842
-
Phase1/-2 study of pomalidomide in myelofibrosis
-
in press, DOI: 10.1002/ajh.21598
-
Mesa R, Pardanani A, Hussein K, et al. Phase1/-2 study of pomalidomide in myelofibrosis. Am J Hematol, in press, DOI: 10.1002/ajh.21598.
-
Am J Hematol
-
-
Mesa, R.1
Pardanani, A.2
Hussein, K.3
-
13
-
-
33748205495
-
International Working Group (IWG) consensus criteria for treatment response in myelofibrosis with myeloid metaplasia, for the IWG for Myelofibrosis Research and Treatment (IWG-MRT)
-
Tefferi A, Barosi G, Mesa RA, et al. International Working Group (IWG) consensus criteria for treatment response in myelofibrosis with myeloid metaplasia, for the IWG for Myelofibrosis Research and Treatment (IWG-MRT). Blood 2006;108:1497-1503.
-
(2006)
Blood
, vol.108
, pp. 1497-1503
-
-
Tefferi, A.1
Barosi, G.2
Mesa, R.A.3
-
14
-
-
71949121402
-
Pomalidomide is active in the treatment of anemia associated with myelofibrosis
-
Tefferi A, Verstovsek S, Barosi G, et al. Pomalidomide is active in the treatment of anemia associated with myelofibrosis. J Clin Oncol 2009;27:4563-4569.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4563-4569
-
-
Tefferi, A.1
Verstovsek, S.2
Barosi, G.3
-
15
-
-
34447634117
-
Lenalidomide therapy in del(5)(q31)-associated myelofibrosis: Cytogenetic and JAK2V617F molecular remissions
-
Tefferi A, Lasho TL, Mesa RA, et al. Lenalidomide therapy in del(5)(q31)-associated myelofibrosis: Cytogenetic and JAK2V617F molecular remissions. Leukemia 2007;21:1827-1828.
-
(2007)
Leukemia
, vol.21
, pp. 1827-1828
-
-
Tefferi, A.1
Lasho, T.L.2
Mesa, R.A.3
-
16
-
-
33747167338
-
Lenalidomide therapy in myelofibrosis with myeloid metaplasia
-
Tefferi A, Cortes J, Verstovsek S, et al. Lenalidomide therapy in myelofibrosis with myeloid metaplasia. Blood 2006;108:1158-1164.
-
(2006)
Blood
, vol.108
, pp. 1158-1164
-
-
Tefferi, A.1
Cortes, J.2
Verstovsek, S.3
-
17
-
-
0036243117
-
Thalidomide treatment in myelofibrosis with myeloid metaplasia
-
Elliott MA, Mesa RA, Li CY, et al. Thalidomide treatment in myelofibrosis with myeloid metaplasia. Br J Haematol 2002;117:288-296.
-
(2002)
Br J Haematol
, vol.117
, pp. 288-296
-
-
Elliott, M.A.1
Mesa, R.A.2
Li, C.Y.3
-
18
-
-
41949130070
-
Improved survival in multiple myeloma and the impact of novel therapies
-
Kumar SK, Rajkumar SV, Dispenzieri A, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 2008;111:2516-2520.
-
(2008)
Blood
, vol.111
, pp. 2516-2520
-
-
Kumar, S.K.1
Rajkumar, S.V.2
Dispenzieri, A.3
-
19
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma [see comments]
-
Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma [see comments]. N Engl J Med 1999;341:1565-1571.
-
(1999)
N Engl J Med
, vol.341
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
-
20
-
-
0037216068
-
Response rate, durability of response, and survival after thalidomide therapy for relapsed multiple myeloma
-
Kumar S, Gertz MA, Dispenzieri A, et al. Response rate, durability of response, and survival after thalidomide therapy for relapsed multiple myeloma. Mayo Clin Proc 2003;78:34-39.
-
(2003)
Mayo Clin Proc
, vol.78
, pp. 34-39
-
-
Kumar, S.1
Gertz, M.A.2
Dispenzieri, A.3
-
21
-
-
51649117633
-
A systematic review of phase II trials of thalidomide/dexamethasone combination therapy in patients with relapsed or refractory multiple myeloma
-
von Lilienfeld-Toal M, Hahn-Ast C, Furkert K, Hoffmann F, Naumann R, Bargou R, Cook G, Glasmacher A. A systematic review of phase II trials of thalidomide/dexamethasone combination therapy in patients with relapsed or refractory multiple myeloma. Eur J Haematol 2008;81:247-252.
-
(2008)
Eur J Haematol
, vol.81
, pp. 247-252
-
-
von Lilienfeld-Toal, M.1
Hahn-Ast, C.2
Furkert, K.3
Hoffmann, F.4
Naumann, R.5
Bargou, R.6
Cook, G.7
Glasmacher, A.8
-
22
-
-
36349023319
-
Lenalidomide plus Dexamethasone for relapsed or refractory multiple myeloma
-
Dimopoulos M, Spencer A, Attal M, et al. Lenalidomide plus Dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med 2007;357:2123-2132.
-
(2007)
N Engl J Med
, vol.357
, pp. 2123-2132
-
-
Dimopoulos, M.1
Spencer, A.2
Attal, M.3
-
23
-
-
36349010285
-
Lenalidomide plus Dexamethasone for Relapsed Multiple Myeloma in North America
-
Weber DM, Chen C, Niesvizky R, et al. Lenalidomide plus Dexamethasone for Relapsed Multiple Myeloma in North America. N Engl J Med 2007;357:2133-2142.
-
(2007)
N Engl J Med
, vol.357
, pp. 2133-2142
-
-
Weber, D.M.1
Chen, C.2
Niesvizky, R.3
-
24
-
-
34848824393
-
Long-term results of response to therapy, time to progression, and survival with lenalidomide plus dexamethasone in newly diagnosed myeloma
-
Lacy MQ, Gertz MA, Dispenzieri A, et al. Long-term results of response to therapy, time to progression, and survival with lenalidomide plus dexamethasone in newly diagnosed myeloma. Mayo Clin Proc 2007;82:1179-1184.
-
(2007)
Mayo Clin Proc
, vol.82
, pp. 1179-1184
-
-
Lacy, M.Q.1
Gertz, M.A.2
Dispenzieri, A.3
-
25
-
-
27744492561
-
Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
-
Rajkumar SV, Hayman SR, Lacy MQ, et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood 2005;106:4050-4053.
-
(2005)
Blood
, vol.106
, pp. 4050-4053
-
-
Rajkumar, S.V.1
Hayman, S.R.2
Lacy, M.Q.3
-
26
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003;348:2609-2617.
-
(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
27
-
-
54249122860
-
Phase I-II trial of bortezomib plus oral cyclophosphamide and prednisone in relapsed and refractory multiple myeloma
-
Reece DE, Rodriguez GP, Chen C, et al. Phase I-II trial of bortezomib plus oral cyclophosphamide and prednisone in relapsed and refractory multiple myeloma. J Clin Oncol 2008;26:4777-4783.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4777-4783
-
-
Reece, D.E.1
Rodriguez, G.P.2
Chen, C.3
-
28
-
-
34848815741
-
The combination of cyclophosphamide, velcade and dexamethasone induces high response rates with comparable toxicity to velcade alone and velcade plus dexamethasone
-
Davies FE, Wu P, Jenner M, et al. The combination of cyclophosphamide, velcade and dexamethasone induces high response rates with comparable toxicity to velcade alone and velcade plus dexamethasone. Haematologica 2007;92:1149-1150.
-
(2007)
Haematologica
, vol.92
, pp. 1149-1150
-
-
Davies, F.E.1
Wu, P.2
Jenner, M.3
-
29
-
-
34447114537
-
Bortezomib in combination with intermediate-dose dexamethasone and continuous low-dose oral cyclophosphamide for relapsed multiple myeloma
-
Kropff M, Bisping G, Schuck E, et al. Bortezomib in combination with intermediate-dose dexamethasone and continuous low-dose oral cyclophosphamide for relapsed multiple myeloma. Br J Haematol 2007;138:330-337.
-
(2007)
Br J Haematol
, vol.138
, pp. 330-337
-
-
Kropff, M.1
Bisping, G.2
Schuck, E.3
-
30
-
-
34548539381
-
Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression
-
Orlowski RZ, Nagler A, Sonneveld P, et al. Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression. J Clin Oncol 2007;25:3892-3901.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3892-3901
-
-
Orlowski, R.Z.1
Nagler, A.2
Sonneveld, P.3
-
31
-
-
33947575994
-
-
Palumbo A, Ambrosini MT, Benevolo G, et al. Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma. Blood 2007;109:2767-2772.
-
Palumbo A, Ambrosini MT, Benevolo G, et al. Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma. Blood 2007;109:2767-2772.
-
-
-
-
32
-
-
4344693453
-
-
Schey SA, Fields P, Bartlett JB, et al. Phase I Study of an Immunomodulatory Thalidomide Analog, CC-4047, in Relapsed or Refractory Multiple Myeloma J Clin Oncol 2004;22:3269-3276.
-
Schey SA, Fields P, Bartlett JB, et al. Phase I Study of an Immunomodulatory Thalidomide Analog, CC-4047, in Relapsed or Refractory Multiple Myeloma J Clin Oncol 2004;22:3269-3276.
-
-
-
-
33
-
-
40449135275
-
Alternate day pomalidomide retains antimyeloma effect with reduced adverse events and evidence of in vivo immunomodulation
-
Streetly MJ, Gyertson K, Daniel Y, et al. Alternate day pomalidomide retains antimyeloma effect with reduced adverse events and evidence of in vivo immunomodulation. Br J Haematol 2008;141:41-51.
-
(2008)
Br J Haematol
, vol.141
, pp. 41-51
-
-
Streetly, M.J.1
Gyertson, K.2
Daniel, Y.3
-
34
-
-
73849086725
-
Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma
-
Lacy MQ, Hayman SR, Gertz MA, et al. Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma. J Clin Oncol 2009;27:5008-5014.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5008-5014
-
-
Lacy, M.Q.1
Hayman, S.R.2
Gertz, M.A.3
-
35
-
-
58249097191
-
Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma
-
Kyle RA, Rajkumar SV. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia 2009;23:3-9.
-
(2009)
Leukemia
, vol.23
, pp. 3-9
-
-
Kyle, R.A.1
Rajkumar, S.V.2
|