Hypoglycemic and hypolipidemic activity of Wrightia tinctoria L. in alloxan induced diabetes in albino wistar rats

Pharmacologyonline

Volumn 3, Issue , 2009, Pages 550-559

  Ashok Raj, R ^a   Saravana Kumar, A ^b   Gandhimathi, R ^b  

^a Adamas India Pharmaceuticals Private Limited   (India)

^b Prince Dr K Vasudevan College of Engineering and Technology   (India)

Author keywords

Alloxan induced diabetes; Antidiabetic activity; Total cholesterol; Triglycerides; Wrightia tinctoria L

Indexed keywords

ALLOXAN; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; GLIBENCLAMIDE; GLUCOSE; PETROLEUM ETHER; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; WRIGHTIA TINCTORIA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOCYNACEAE; ARTICLE; BODY WEIGHT; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; HYPOLIPEMIA; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WRIGHTIA TINCTORIA;

EID: 75449096203     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. nd Ed. 1997; 3.1-3.28.
2. Payne C. Complementary and integrative medicine: emerging therapies for diabetes. Diabetes Spectrum 2001:14; 129-131.
3. Rai PK, Singh SK, Kesari AN and Watal G. Glycemic evaluation of Psidium guajava in rats. Indian Journal of Medical Research. 2007:126; 224-227.
4. Madhava Chetty K. "Wrightia tinctoria Linn." Chittor medicinal plants, Himalaya Book Publications, Tirupathi, 2008; 147.
5. Mitra SK, Seshadri SJ, Venkataranganna MV and Gopumadhvan S. Reversal of parakeratosis, a feature of psoriasis by Wrightia tinctoria (in emulsion) histological evaluation based on mouse tail. Indian Journal of Dermatology. 1998:43(3); 102-104.
6. Krishnamoorthy JR and Ranganathan S. Antipityrosporum ovale activity of an herbal drug combination of Wrightia tinctoria and Hisbiscus rosasinensis. Indian Journal of Dermatology. 2000:45: 125-26.
7. Chopra RN, Nayar SL and Chopra IC. Glossary of Indian Medicinal Plants. CSIR Publications, New Delhi, 1956; 345.
8. Bigoniya P, Rana AC and Agrawal GP. Evaluation of the antiulcer activity of hydroalcoholic extract of Wrightia tinctoria bark in experimentally induced acute gastric ulcers on rat. Nig. J Nat. Pro. Med. 2006:10;36-40.
9. Harbone JP, Phytochemical methods, a guide to modern technique of plant analysis (Chapmann and Hall, London). 1973;1-271.
10. OECD, 2002. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the, OECD, guidelines for the testing of chemicals organisation for economical co-operation and development, Paris, June, 2000.
11. Dash GK, Suresh P, Ganapaty S. Studies on hypoglycaemic and wound healing activities of Lantana camara Linn. Journal of Natural Remedies. 2001: 1; 105-110.
12. Sood R. Diabetes Mellitus. Medical laboratory Technology - Methods and Interpretations. Jaypee 1999.
13. Sharma SB, Hasir A, Prabhu KM, Murthy PS and Dwv G. Hypoglycemic and Hypolipedemic effect of ethanolic extracts of seeds of Eugenia Jambolona in Alloxan induced Diabetic rabbits. Journal of Ethanopharmacology. 2003:85; 201-206.
14. Bierman EL, Amaral JAP and Balknap BH. Hyperlipidemia and Diabetes Mellitus. Diabetes. 1975:25; 509-515.
15. th Ed., 2003;156-162.
16. Qiong L, Yizhong C, Jun Y, Mei S. and Harold C. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Science. 2004:76; 137-149.
17. Umesh CS, Yadav K, Moorthy K. and Najma ZB. Combined treatment of sodium orthovanadate and Mormodica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes on Alloxan diabetic rats. Molecular and Cellular Biochemistry, 2005; 111-120.
18. Pari L. and Amarnanth S. Antidiabetic activity of boerhavia diffusa. Effect on hepatic key enzymes in experimental diabetes. Journal of Ethanopharmacol. 2004:91; 109-113.
19. Maiti R, Das UK. and Ghosh D. Attenuation of hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats by aqueous extract of seed of Tamarindus indica. Biological and Pharmaceutical Bulletin. 2005:28; 172-1176.
20. Pushparaj P, Tan CH. and Tan BKM. Effect of Averrhoa bilimb leaf extract on Blood Glucose and lipids in Streptozotocin- diabetic rats. Journal of Ethnopharmacology. 2000:72; 69-76.
21. Krishnakumar K, Augustti KT. and Vijayammal PL. Hypolipedemic effect of Solacia oblanga wall. Root bark in Streptozotocin diabetic rats. Med. Sci. 2000:28; 65-67.
22. Sethupathy S, Elanchezhiyan C, Vasudevan K. and Rajgopal G. Antiatherogenic effect taurine in high fat diet fed rats. Indian J. Exp. Biol.2002: 40; 1169.
23. Frayn KN. Insulin resistance and lipid metabolism. Curr. Opin. Lipidol. 1993:4; 197-204.