Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure 'biomarker' signals and induction of inflammatory, innate immune and apoptotic pathways

Aquatic Toxicology

Volumn 96, Issue 3, 2010, Pages 234-245

  Leaver, Michael J ^a   Diab, Amer ^a   Boukouvala, Evridiki ^a,b,c   Williams, Tim D ^b   Chipman, J Kevin ^b   Moffat, Colin F ^d   Robinson, Craig D ^d   George, Stephen G ^a  

^a UNIVERSITY OF STIRLING   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c INSTITUTE OF TECHNOLOGY OF AGRICULTURAL PRODUCTS   (Greece)

^d MARINE LABORATORY   (United Kingdom)

Author keywords

Benzo(a)pyrene; Chronic exposure; Cyp1A; Diablo; Estradiol; Flounder; Genomics; Hepatocytes; Microarray; Pollution; Smac; Vitellogenin

Indexed keywords

BENZO[A]PYRENE; BIOLOGICAL MARKER; CARBON; COMPLEMENTARY DNA; COPPER; DIMETHYL SULFOXIDE; ESTRADIOL; MESSENGER RNA; METAL; ORGANOCHLORINE PESTICIDE; ORGANOTIN COMPOUND; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE;

APOPTOSIS; BIOMARKER; DETECTION METHOD; ESTUARINE ECOSYSTEM; ESTUARINE POLLUTION; ESTUARINE SEDIMENT; FLATFISH; GENE EXPRESSION; GENOMICS; IMMUNE SYSTEM; MESOCOSM; POLLUTION EXPOSURE; SEDIMENT POLLUTION;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; ECOTOXICOLOGY; ENVIRONMENTAL EXPOSURE; ESTUARINE SPECIES; ESTUARY; FEMALE; FISH GENETICS; FLOUNDER; GENE EXPRESSION REGULATION; GENETIC CODE; INFLAMMATION; INNATE IMMUNITY; LIVER CELL; LONG TERM EXPOSURE; MALE; MESOCOSM; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TOXICITY TESTING; TRANSCRIPTOMICS; WATER CONTAMINATION; WATER POLLUTANT;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; FLOUNDER; GENE EXPRESSION REGULATION; GEOLOGIC SEDIMENTS; HEPATOCYTES; IMMUNITY, INNATE; INFLAMMATION; LIVER; WATER POLLUTANTS, CHEMICAL;

PLATICHTHYS FLESUS; PLEURONECTOIDEI;

EID: 75449092200     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2009.10.025     Document Type: Article

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