Murine cytomegalovirus US22 protein pM140 protects its binding partner, pM141, from proteasome-dependent but ubiquitin-independent degradation

Journal of Virology

Volumn 84, Issue 4, 2010, Pages 2164-2168

  Bolin, Lisa L ^a,b   Hanson, Laura K ^a,c   Slater, Jacquelyn S ^a   Kerry, Julie A ^a   Campbell, Ann E ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TEXAS WOMAN'S UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; EPOXOMICIN; M140 PROTEIN; M141 PROTEIN; PROTEASOME; PROTEASOME INHIBITOR; UBIQUITIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOMEGALOVIRUS; MACROPHAGE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STEADY STATE; US22 GENE; VIRION; VIRUS ASSEMBLY; VIRUS GENOME; VIRUS REPLICATION; WESTERN BLOTTING;

ANIMALS; AUTOPHAGY; GENES, VIRAL; MICE; MULTIPROTEIN COMPLEXES; MUROMEGALOVIRUS; NIH 3T3 CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; UBIQUITIN; VIRAL PROTEINS; VIRUS ASSEMBLY;

MURID HERPESVIRUS 1;

EID: 75449084620     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01739-09     Document Type: Article

References (19)

1. Cavanaugh, V. J., R. M. Stenberg, T. L. Staley, H. W. Virgin IV, M. R. Mac-Donald, S. Paetzold, H. E. Farrell, W. D. Rawlinson, and A. E. Campbell. 1996. Murine cytomegalovirus with a deletion of genes spanning HindIII-J and -I displays altered cell and tissue tropism. J. Virol. 70:1365-1374.
2. Chowdary, D. R., J. J. Dermody, K. K. Jha, and H. L. Ozer. 1994. Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway. Mol. Cell. Biol. 14:1997-2003.
3. Corboy, M. J., P. J. Thomas, and W. C. Wigley. 2005. Aggresome formation. Methods Mol. Biol. 301:305-327.
4. Fehr, A. R., and D. Yu. 2010. Human cytomegalovirus gene UL21a encodes a short-lived cytoplasmic protein and facilitates virus replication in fibroblasts. J. Virol. 84:291-302.
5. Fortunato, E. A., V. Sanchez, J. Y. Yen, and D. H. Spector. 2002. Infection of cells with human cytomegalovirus during S phase results in a blockade to immediate-early gene expression that can be overcome by inhibition of the proteasome. J. Virol. 76:5369-5379.
6. Garcia-Mata, R., Z. Bebok, E. J. Sorscher, and E. S. Sztul. 1999. Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. J. Cell Biol. 146:1239-1254.
7. Gordon, K. L., and P. Gonzalez-Alegre. 2008. Consequences of the DYT1 mutation on torsin A oligomerization and degradation. Neuroscience 157: 588-595.
8. Hanson, L. K., and A. E. Campbell. 2006. Determinants of macrophage tropism, p. 419-443. In M. J. Reddehase (ed.), Cytomegaloviruses: molecular biology and immunology. Caister Academic Press, Norfolk, United Kingdom.
9. Hanson, L. K., B. L. Dalton, L. F. Cageao, R. E. Brock, J. S. Slater, J. A. Kerry, and A. E. Campbell. 2005. Characterization and regulation of essential murine cytomegalovirus genes m142 and m143. Virology 334:166-177.
10. Hanson, L. K., B. L. Dalton, Z. Karabekian, H. E. Farrell, W. D. Rawlinson, R. M. Stenberg, and A. E. Campbell. 1999. Transcriptional analysis of the murine cytomegalovirus HindIII-I region: identification of a novel immediate-early gene region. Virology 260:156-164.
11. Hanson, L. K., J. S. Slater, V. J. Cavanaugh, W. W. Newcomb, L. L. Bolin, C. N. Nelson, L. D. Fetters, Q. Tang, J. C. Brown, G. G. Maul, and A. E. Campbell. 2009. Murine cytomegalovirus capsid assembly is dependent on US22 family gene M140 in infected macrophages. J. Virol. 83:7449-7456.
12. Hanson, L. K., J. S. Slater, Z. Karabekian, G. Ciocco-Schmitt, and A. E. Campbell. 2001. Products of US22 genes M140 and M141 confer efficient replication of murine cytomegalovirus in macrophages and spleen. J. Virol. 75:6292-6302.
13. Hwang, J., and R. F. Kalejta. 2007. Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells. Virology 367:334-338.
14. Kalejta, R. F., and T. Shenk. 2003. Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein. Proc. Natl. Acad. Sci. U. S. A. 100:3263-3268.
15. Karabekian, Z., L. K. Hanson, J. S. Slater, N. K. Krishna, L. L. Bolin, J. A. Kerry, and A. E. Campbell. 2005. Complex formation among murine cytomegalovirus US22 proteins encoded by genes M139, M140, and M141. J. Virol. 79:3525-3535.
16. Klionsky, D. J., H. Abeliovich, P. Agostinis, D. K. Agrawal, G. Aliev, D. S. Askew, M. Baba, E. H. Baehrecke, B. A. Bahr, A. Ballabio, B. A. Bamber, D. C. Bassham, E. Bergamini, X. Bi, M. Biard-Piechaczyk, J. S. Blum, D. E. Bredesen, J. L. Brodsky, J. H. Brumell, U. T. Brunk, W. Bursch, N. Camougrand, E. Cebollero, F. Cecconi, Y. Chen, L. S. Chin, A. Choi, C. T. Chu, J. Chung, P. G. Clarke, R. S. Clark, S. G. Clarke, C. Clave, J. L. Cleveland, P. Codogno, M. I. Colombo, A. Coto-Montes, J. M. Cregg, A. M. Cuervo, J. Debnath, F. Demarchi, P. B. Dennis, P. A. Dennis, V. Deretic, R. J. Devenish, F. Di Sano, J. F. Dice, M. Difiglia, S. Dinesh-Kumar, C. W. Distelhorst, M. Djavaheri-Mergny, F. C. Dorsey, W. Droge, M. Dron, W. A. Dunn, Jr., M. Duszenko, N. T. Eissa, Z. Elazar, A. Esclatine, E. L. Eskelinen, L. Fesus, K. D. Finley, J. M. Fuentes, J. Fueyo, K. Fujisaki, B. Galliot, F. B. Gao, D. A. Gewirtz, S. B. Gibson, A. Gohla, A. L. Goldberg, R. Gonzalez, C. Gonzalez-Estevez, S. Gorski, R. A. Gottlieb, D. Haussinger, Y. W. He, K. Heidenreich, J. A. Hill, M. Hoyer-Hansen, X. Hu, W. P. Huang, A. Iwasaki, M. Jaattela, W. T. Jackson, X. Jiang, S. Jin, T. Johansen, J. U. Jung, M. Kadowaki, C. Kang, A. Kelekar, D. H. Kessel, J. A. Kiel, H. P. Kim, A. Kimchi, T. J. Kinsella, K. Kiselyov, K. Kitamoto, E. Knecht, et al. 2008. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175.
17. Menard, C., M. Wagner, Z. Ruzsics, K. Holak, W. Brune, A. E. Campbell, and U. H. Koszinowski. 2003. Role of murine cytomegalovirus US22 gene family members in replication in macrophages. J. Virol. 77:5557-5570.
18. Treier, M., L. M. Staszewski, and D. Bohmann. 1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78:787-798.
19. Wileman, T. 2007. Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design? Annu. Rev. Microbiol. 61:149-167.