Effect of beta-blockers, Ca2+ antagonists, and benzodiazepines on bleeding incidence in patients with chemotherapy induced thrombocytopenia

Platelets

Volumn 21, Issue 1, 2010, Pages 77-83

  Rysler, Christine ^a   Stoffel, Nadina ^a   Buser, Andreas ^a   Gratwohl, Alois ^a   Tsakiris, Dimitrios A ^a   Stern, Martin ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Benzodiazepines; Beta blockers; Bleeding; Ca2+ antagonists; Chemotherapy

Indexed keywords

ALPRAZOLAM; AMLODIPINE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; BROMAZEPAM; BUSULFAN; CALCIUM ANTAGONIST; CARBOPLATIN; CARMUSTINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DALTEPARIN; DAUNORUBICIN; DILTIAZEM; ETOPOSIDE; FLUDARABINE; IDARUBICIN; IFOSFAMIDE; LORAZEPAM; LOW MOLECULAR WEIGHT HEPARIN; MELPHALAN; METOPROLOL; MIDAZOLAM; MITOXANTRONE; NIFEDIPINE; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BLEEDING; CHRONIC MYELOID LEUKEMIA; COHORT ANALYSIS; DISEASE SEVERITY; DRUG EXPOSURE; FEMALE; GERM CELL TUMOR; GRAFT VERSUS HOST REACTION; HUMAN; IATROGENIC DISEASE; IN VIVO STUDY; INCIDENCE; INFLAMMATION; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; MYELOID METAPLASIA; PRIORITY JOURNAL; RISK ASSESSMENT; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTOPENIA; UREMIA;

ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; BENZODIAZEPINES; CALCIUM CHANNEL BLOCKERS; DRUG THERAPY; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION; RISK FACTORS; THROMBOCYTOPENIA; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 75449083207     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537100903388359     Document Type: Article

References (16)

1. Morse EE. Effects of drugs on platelet function. Ann Clin Lab Sci 1977;7:68-72.
2. Sarkiss MG, Yusuf SW, Warneke CL, Botz G, Lakkis N, Hirch-Ginsburg C, Champion JC, Swafford J, Shaw AD, Lenihan DJ, et al. Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes. Cancer 2007;109:621-627.
3. Winther K, Rein E. Exercise-induced platelet aggregation in angina and its possible prevention by beta 1-selective blockade. Eur Heart J 1990;11:819-823.
4. Hjemdahl P, Larsson PT. Wallen NH. Effects of stress and beta-blockade on platelet function. Circulation 1991; 84(Suppl):VI44-61.
5. Hjemdahl P, Wallen NH. Calcium antagonist treatment, sympathetic activity and platelet function. Eur Heart J 1997;18(Suppl A):A36-50.
6. Nadar S, Blann AD, Lip GY. Platelet morphology and plasma indices of platelet activation in essential hypertension: Effects of amlodipine-based antihypertensive therapy. Ann Med 2004;36:552-557.
7. Hsiao G, Shen MY, Chou DS, Chang Y, Lee LW, Lin CH, Sheu JR. Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies. Eur J Pharmacol 2004;487:159-166.
8. Sheu JR, Hsiao G, Luk HN, Chen YW, Chen TL, Lee LW, Lin CH, Chou DS. Mechanisms involved in the antiplatelet activity of midazolam in human platelets. Anesthesiology 2002;96:651-658. (Pubitemid 34193506)
9. Buchanan GR, Adix L. Grading of hemorrhage in children with idiopathic thrombocytopenic purpura. J Pediatr 2002; 141:683-688.
10. Slichter SJ, David K, Enright H, Braine H, Gernsheimer T, Kao KJ, Kickler T, Lee E, McFarland J, McCullough J, et al. Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients. Blood 2005;105:4106-4214.
11. Pihusch M. Bleeding complications after hematopoietic stem cell transplantation. Semin Hematol 2004;41(Suppl 1): 93-100.
12. Escolar G, Diaz-Ricart M, Cases A. Uremic platelet dysfunction: Past and present. Curr Hematol Rep 2005; 4:359-367.
13. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974; 18:295-304.
14. Ertault-Daneshpouy M, Leboeuf C, Lemann M, Bouhidel F, Ades L, Gluckman E, Socie G, Janin A. Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease. Blood 2004;103:4681-4684.
15. Holler E, Kolb HJ, Greinix H, Perrotin D, Campilho F, Aversa F, Gil L, Cornelissen J, Varanese L, Schacht A, et al. Bleeding events and mortality in SCT patients: A retrospective study of hematopoietic SCT patients with organ dysfunctions due to severe sepsis or GVHD. Bone Marrow Transplant 2009;43:491-497.
16. Boccardo P, Remuzzi G, Galbusera M. Platelet dysfunction in renal failure. Semin Thromb Hemost 2004;30:579-589.