Does cardiac pacing reproduce the mechanism of focal impulse initiation?

Journal of Electrocardiology

Volumn 37, Issue SUPPL., 2004, Pages 135-143

  Macchi, Emilio ^a,d   Baruffi, Silvana ^a   Rossi, Stefano ^a   Miragoli, Michele ^a   Bertuzzi, Andrea ^a   Musso, Ezio ^a   Corradi, Domenico ^b   Di Gregorio, Franco ^c  

^a Sezione di Fisiologia Umana   (Italy)

^b Istituto di Patologia Medica   (Italy)

^c (PD)   (Italy)

^d UNIVERSITY OF PARMA   (Italy)

Author keywords

breakthrough point; cardiac electrophysiology; Cardiac pacing; epicardial mapping; focal activity

Indexed keywords

ANIMAL TISSUE; ARTIFICIAL HEART PACEMAKER; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRIC POTENTIAL; EPICARDIUM MAPPING; HEART EXCITATION; HEART MUSCLE; HEART PACING; HEART STIMULATION; HEART VENTRICLE; INFORMATION PROCESSING; INTERMETHOD COMPARISON; ISOLATED HEART; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SENESCENCE; SINUS RHYTHM; WAVEFORM;

ANIMALS; BODY SURFACE POTENTIAL MAPPING; CARDIAC PACING, ARTIFICIAL; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HEART VENTRICLES; MEMBRANE POTENTIALS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; PERICARDIUM; PURKINJE FIBERS; RATS; VENTRICULAR PREMATURE COMPLEXES;

EID: 7544249394     PISSN: 00220736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jelectrocard.2004.08.038     Document Type: Conference Paper

References (12)

1. Rushton W.A.H. Initiation of the propagated disturbance. Proc R Soc B. 124:1937;210
2. Sepulveda N.G., Roth B.J., Wikswo J.P. Jr. Current injection into a two-dimensional anisotropic bidomain. Biophys J. 55:1989;987
3. Wikswo J.P. Jr, Lin S.F., Abbas R.A. Virtual electrodes in cardiac tissue A common mechanism for anodal and cathodal stimulation. Biophys J. 69:1995;2195
4. Roth B.J., Wikswo J.P. Jr. Electrical stimulation of cardiac tissue A bidomain model with active membrane properties. IEEE Trans Biomed Eng. 41:1994;232
5. Akar F.G., Roth B.J., Rosenbaum D.S. Optical measurement of cell-to-cell coupling in intact heart using subthreshold electrical stimulation. Am J Physiol. 281:2001;H533
6. Sambelashvili A.T., Nikolski V.P., Efimov I.R. Nonlinear effects in subthreshold virtual electrode polarization. Am J Physiol Heart. 284:2003;H2368
7. Macchi E., Cavalieri M., Stilli D., et al. High-density epicardial mapping during current injection and ventricular activation in rat hearts. Am J Physiol. 275:1998;H1886
8. Spach M.S., Kootsey J.M. Relating the sodium current and conductance to the shape of transmembrane and extracellular potentials by simulation effects of propagation boundaries. IEEE Trans Biomed Eng. 32:1985;743
9. Fast V.G., Darrow B.J., Saffitz J.E., et al. Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping Role of tissue discontinuities. Circ Res. 79:1996;115
10. Rossi S., Baruffi S., Macchi E., et al. Liminal length, excitability and the mechanism of impulse initiation in cardiac muscle. Pfluger Arch-Eur J Physiol. 445:2003;R55
11. Colli Franzone P., Guerri L., Pennacchio M., et al. Spread of excitation in 3-D models of the anisotropic cardiac tissue III. Effects of ventricular geometry and fiber structure on the potential distribution. Math Biosci. 151:1998;51
12. Wikswo J.P. Jr, Wisialowski T.A., Altemeier W.A., et al. Virtual cathode effects during stimulation of cardiac muscle Two-dimensional in vivo experiments. Circ Res. 68:1991;513