Development and validation of enzyme-linked immunosorbent assays for quantification of anti-methotrexate IgG and Fab in mouse and rat plasma

Journal of Immunoassay and Immunochemistry

Volumn 25, Issue 4, 2004, Pages 335-344

  Tayab, Zia R ^a   Balthasar, Joseph P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Antibody; Enzyme immunoassay; Methotrexate; Pharmacokinetics; Targeting

Indexed keywords

DRUG ANTIBODY; METHOTREXATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY METHOTREXATE IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY METHOTREXATE IMMUNOGLOBULIN G; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; BLOOD SAMPLING; CANNULA; CHEMOTHERAPY; CONTROLLED STUDY; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; JUGULAR VEIN; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; MALE; METHOTREXATE; MICE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SERUM ALBUMIN;

EID: 7544224075     PISSN: 15321819     EISSN: None     Source Type: Journal    
DOI: 10.1081/IAS-200033830     Document Type: Article

References (15)

1. American Cancer Society. Facts and Figures: 2003; American Cancer Society: Atlanta, 2003.
2. Luce, T.L.; Dow, K.H.; Holcomb, L. Early diagnosis key to epithelial ovarian cancer detection. Nurse Pract. 2003, 28 (12), 41-47.
3. Goel, R.; Cleary, S.M.; Horton, C.; Balis, F.M.; Zimm, S.; Kirmani, S.; Howell, S.B. Selective intraperitoneal biochemical modulation of methotrexate by dipyridamole. J. Clin. Oncol. 1989, 7 (2), 262-269.
4. Dedrick, R.L.; Myers, C.E.; Bungay, P.M.; DeVita, V.T. Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer. Cancer Treat. Rep. 1978, 62 (1), 1-11.
5. Howell, S.B.; Pfeifle, C.E.; Olshen, R.A. Intraperitoneal chemotherapy with melphalan. Ann. Int. Med. 1984, 101 (1), 14-18.
6. Howell, S.B.; Chu, B.B.; Wung, W.E.; Metha, B.M.; Mendelsohn, J. Long-duration intracavity infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions. J. Clin. Invest. 1981, 67 (4), 1161-1170.
7. Howell, S.B.; Pfeifle, C.L.; Wung, W.E.; Olshen, R.A.; Lucas, W.E.; Yon, J.L.; Green, M. Intraperitoneal cisplatin with systemic thiosulfate protection. Ann. Int. Med. 1982, 97 (6), 845-851.
8. Speyer, J.L.; Collins, J.M.; Dedrick, R.L.; Brennan, M.F.; Buckpitt, A.R.; Londer, H.; Devita, V.T.; Myers, C.E. Phase I and pharmacological studies of 5-flurouracil administered intraperitoneally. Cancer Res. 1980, 40 (3), 306-311.
9. Pfeiffer, P.; Bennedback, O.; Bertelsen, K. Intraperitoneal carboplatin in the treatment of minimal residual ovarian cancer. Gynecol. Oncol. 1990, 36(3), 1035-1043.
10. Balthasar, J.P.; Fung, H.L. Utilization of antidrug antibody fragments for the optimization of intraperitoneal drug therapy: studies using digoxin as a model drug. J. Pharmacol. Exp. Ther. 1994, 268 (2), 734-739.
11. Balthasar, J.P.; Fung, H.L. Inverse targeting of peritoneal tumors: selective alteration of the disposition of methotrexate through the use of anti-methotrexate antibodies and antibody fragments. J. Pharm. Sci. 1996, 85 (10), 1035-1043.
12. Balthasar, J.P.; Fung, H.L. High-affinity rabbit antibodies directed against methotrexate: production, purification, characterization and pharmacokinetics in the rat. J. Pharm. Sci. 1995, 84 (1), 2-6.
13. Harlow, E.; Lane, D. Appendix II: protein techniques. In Antibodies: A Laboratory Manual; Cold Spring Harbor Laboratory: New York, 1988; 673.
14. Bazin Redureau, M.I.; Renard, C.B.; Scherrman, J.M. Pharmacokinetics of heterologous and homologous immunoglobulin G, F(ab′)2 and Fab after intravenous administration in the rat. J. Pharm. Pharmacol. 1997, 49 (3), 277-281.
15. Caballero, F.; Pelegri, C.; Castell, M.; Franch, A.; Castellote, C. Kinetics of W3/25 anti-rat CD4 monoclonal antibody. Studies on optimal doses and time-related effects. Immunopharmacology 1998, 39 (2), 83-91.