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Volumn 878, Issue 5-6, 2010, Pages 525-537
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Liquid chromatography and tandem mass spectrometry for the quantitative determination of ixabepilone (BMS-247550, Ixempra™) in human plasma: Method validation, overcoming curve splitting issues and eliminating chromatographic interferences from degradants
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Author keywords
Adsorption; BMS 247550; Calibration issues; Degradants; Ixabepilone; Ixempra ; LC MS MS; Protein precipitation
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Indexed keywords
ACCURACY AND PRECISION;
AMMONIUM ACETATE;
BIOLOGICAL MATRIXES;
CLINICAL STUDY;
DEGRADANTS;
HUMAN PLASMAS;
INTERNAL STANDARDS;
ION PAIRS;
IONIZATION MODES;
LC-MS/MS;
METHOD VALIDATIONS;
MOBILE PHASE;
MULTIPLE REACTION MONITORING;
ORAL ADMINISTRATION;
PLASMA SAMPLES;
POTENTIAL INTERFERENCES;
PROTEIN PRECIPITATION;
QUADRATIC REGRESSION;
QUANTITATIVE ANALYSIS;
QUANTITATIVE DETERMINATIONS;
SAMPLE ANALYSIS;
SENSITIVE METHOD;
TANDEM MASS SPECTROMETRY;
TURBOIONSPRAY;
ACETONITRILE;
ADSORPTION;
AMMONIUM COMPOUNDS;
CALIBRATION;
CHROMATOGRAPHIC ANALYSIS;
COLUMN CHROMATOGRAPHY;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
IONIZATION OF LIQUIDS;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
PROTEINS;
REGRESSION ANALYSIS;
EXTRACTION;
ACETONITRILE;
AMMONIUM ACETATE;
BMS 212188;
IXABEPILONE;
IXABEPILONE DERIVATIVE;
UNCLASSIFIED DRUG;
ARTICLE;
CONTINUOUS INFUSION;
CONTROLLED STUDY;
DRUG BLOOD LEVEL;
DRUG DETERMINATION;
FLOW RATE;
HUMAN;
HUMAN TISSUE;
LIQUID CHROMATOGRAPHY;
PRECIPITATION;
PRIORITY JOURNAL;
QUANTITATIVE ANALYSIS;
TANDEM MASS SPECTROMETRY;
VALIDATION PROCESS;
CHROMATOGRAPHY, LIQUID;
EPOTHILONES;
HUMANS;
SENSITIVITY AND SPECIFICITY;
TANDEM MASS SPECTROMETRY;
TUBULIN MODULATORS;
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EID: 75349097967
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.12.014 Document Type: Article |
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Times cited : (18)
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References (14)
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