Systemic adverse events following botulinum toxin A therapy in children with cerebral palsy

Developmental Medicine and Child Neurology

Volumn 52, Issue 2, 2010, Pages 139-144

  Naidu, Krishant ^a,b   Smith, Katherine ^b   Sheedy, Mary ^a   Adair, Brooke ^a   Yu, Xavier ^a   Graham, H Kerr ^a,b,c  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BOTULINUM TOXIN A;

ADOLESCENT; ADULT; ARTICLE; CEREBRAL PALSY; CHILD; CONSULTATION; EMERGENCY WARD; FECES INCONTINENCE; FEMALE; HOSPITAL ADMISSION; HUMAN; INCIDENCE; INFANT; MAJOR CLINICAL STUDY; MALE; PRESCRIPTION; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; SPASTICITY; UPPER RESPIRATORY TRACT INFECTION; URINE INCONTINENCE;

ADOLESCENT; BOTULINUM TOXIN TYPE A; CEREBRAL PALSY; CHILD; CHILD, PRESCHOOL; DISABILITY EVALUATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FECAL INCONTINENCE; FEMALE; HUMANS; INFANT; LOGISTIC MODELS; MALE; MOTOR ACTIVITY; NEUROMUSCULAR AGENTS; RESPIRATION DISORDERS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; URINARY INCONTINENCE; YOUNG ADULT;

EID: 75349089851     PISSN: 00121622     EISSN: 14698749     Source Type: Journal    
DOI: 10.1111/j.1469-8749.2009.03583.x     Document Type: Article

References (30)

1. Koman LA, Mooney JF, Smith B, Goodman A, Mulvaney T. Management of cerebral palsy with botulinum-A toxin: preliminary investigation. J Pediatr Orthop 1993, 13:489-95.
2. Cosgrove AP, Corry IS, Graham HK. Botulinum toxin in the management of the lower limb in cerebral palsy. Dev Med Child Neurol 1994, 36:386-96.
3. Baker R, Jasinski M, Maciag-Tymecka I. Botulinum toxin treatment of spasticity in diplegic cerebral palsy: a randomized, double-blind, placebo-controlled, dose-ranging study. Dev Med Child Neurol 2002, 44:666-75.
4. Barwood S, Baillieu C, Boyd R. Analgesic effects of botulinum toxin A: a randomized, placebo-controlled clinical trial. Dev Med Child Neurol 2000, 42:116-21.
5. Koman LA, Mooney JF, Smith BP, Walker F, Leon JM. Botulinum toxin type A neuromuscular blockade in the treatment of lower extremity spasticity in cerebral palsy: a randomized, double-blind, placebo-controlled trial. J Pediatr Orthop 2000, 20:108-15.
6. Love SC, Valentine JP, Blair EM, Price CJ, Cole JH, Chauvel PJ. The effect of botulinum toxin type A on the functional ability of the child with spastic hemiplegia: a randomized controlled trial. Eur J Neurol 2001, 8(Suppl 5):50-8.
7. Moore AP, Ade-Hall RA, Tudu Smith C. Two-year placebo-controlled trial of botulinum toxin A for leg spasticity in cerebral palsy. Neurology 2008, 71:122-8.
8. Ubhi T, Bhakta BB, Ives HL, Allgar V, Roussounis SH. Randomised double blind placebo controlled trial of the effect of botulinum toxin on walking in cerebral palsy. Arch Dis Child 2000, 83:481-7.
9. Corry IS, Cosgrove AP, Duffy CM, McNeill S, Taylor TC, Graham HK. Botulinum toxin A compared with stretching casts in the treatment of spastic equinus: a randomised prospective trial. J Pediatr Orthop 1998, 18:304-11.
10. Ackman JD, Russman BS, Sienko Thomas S. Comparing botulinum toxin A with casting for treatment of dynamic equinus in children with cerebral palsy. Dev Med Child Neurol 2005, 47:620-7.
11. Bottos M, Benedetti MG, Salucci P, Gasparroni V, Giannini S. Botulinum toxin with and without casting in ambulant children with spastic diplegia: a clinical and functional assessment. Dev Med Child Neurol 2003, 45:758-62.
12. Graham HK, Boyd R, Carlin JB. Does botulinum toxin A combined with bracing prevent hip displacement in children with cerebral palsy and " hips at risk" ? A randomized, controlled trial. J Bone Joint Surg Am 2008, 90:23-33.
13. Desloovere K, Molenaers G, Jonkers I. A randomized study of combined botulinum toxin type A and casting in the ambulant child with cerebral palsy using objective outcome measures. Eur J Neurol 2001, 8(Suppl 5):75-87.
14. Flett PH, Stern LM, Waddy H, Connell TM, Seeger JD, Gibson SK. Botulinum toxin A versus fixed cast stretching for dynamic calf tightness in cerebral palsy. J Paediatr Child Health 1999, 35:71-7.
15. Graham HK, Aoki KR, Autti-Rämö I. Recommendations for the use of botulinum toxin type A in the management of cerebral palsy. Gait Posture 2000, 11:67-79.
16. Heinen F, Molenaers G, Fairhurst C. European consensus table 2006 on botulinum toxin for children with cerebral palsy. Eur J Paediatr Neurol 2006, 10:215-25.
17. http://www.citizen.org/pressroom/release.cfm?ID=2593, Public Citizen. Stricter warnings needed for Botox, Myobloc injections. (accessed 29 October 2009)
18. FDA requires boxed warning for all botulinum toxin products. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm149574.htm, (accessed 29 October 2009)
19. Allergan comments on today's follow up by the U.S. Food and Drug Administration (FDA) to its early communication, concluding the agency's safety review of botulinum toxins. http://agn.client.shareholder.com/releasedetail.cfm?ReleaseID=381098, (accessed 29 October 2009)
20. Davy M, Robinson K, Taylor E. Botulinum toxin type A (Botox) and distal toxin spread. Can Adv React Newsl 2008, 18.
21. Topliss D, Goed M, Kotsisilos V, Lander C, McNeie J, Pillans P, Strasser S, Wainwright D. Adverse reactions with botulinum toxin A (Botox, Dysport). Aust Adv Drug Reactions Bull 2009, 28.
22. Palisano R, Rosenbaum P, Walter S, Russell D, Wood E, Galuppi B. Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol 1997, 39:214-23.
23. Graham HK. Classifying cerebral palsy. J Pediatr Orthop 2005, 25:127-8.
24. Koman LA, Mooney JF, Smith BP, Goodman A, Mulvaney T. Management of spasticity in cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial. J Pediatr Orthop 1994, 14:299-303.
25. Molenaers G, Desloovere K, De Cat J. Single event multilevel botulinum toxin type A treatment and surgery: similarities and differences. Eur J Neurol 2001, 8(Suppl 5):88-97.
26. Howell K, Selber P, Graham HK, Reddihough D. Botulinum neurotoxin A: an unusual systemic effect. J Paediatr Child Health 2007, 43:499-501.
27. Chin T, Nattrass G, Selber P, Graham HK. Accuracy of intramuscular injection of botulinum toxin A in juvenile cerebral palsy: a comparison between manual needle placement and placement guided by electrical stimulation. J Pediatr Orthop 2005, 25:286-91.
28. Berweck S, Feldkamp A, Francke A, Nehles J, Schwerin A, Heinen F. Sonography-guided injection of botulinum toxin A in children with cerebral palsy. Neuropediatrics 2002, 33:221-3.
29. Berweck S, Schroeder AS, Fietzek UM, Heinen F. Sonography-guided injection of botulinum toxin in children with cerebral palsy. Lancet 2004, 363:249-50.
30. Altman DG, Bland JM. Missing data. BMJ 2007, 334:424.