Association of epilepsy and comorbid conditions

Future Neurology

Volumn 4, Issue 5, 2009, Pages 663-668

  Seidenberg, Michael ^a   Pulsipher, Dalin T ^a   Hermann, Bruce ^b  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b University of Wisconsin Health   (United States)

Author keywords

ADHD; Bone health; Causal models; Comorbidity; Depression; Epilepsy; Migraine; Risk factors; Stroke

Indexed keywords

ANTICONVULSIVE AGENT; NORADRENALIN;

ATTENTION DEFICIT DISORDER; CARDIOVASCULAR DISEASE; CEREBROVASCULAR DISEASE; CLINICAL FEATURE; COGNITIVE DEFECT; COMORBIDITY; DEPRESSION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ELDERLY CARE; EPILEPSY; FRACTURE; HUMAN; LIPID METABOLISM; MENTAL DISEASE; MIGRAINE; NONHUMAN; NORADRENALIN RELEASE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT;

EID: 75249083791     PISSN: 14796708     EISSN: None     Source Type: Journal    
DOI: 10.2217/fnl.09.32     Document Type: Review

References (52)

1. Gaitatzis A, Carroll K, Majeed A, Sander WJ: The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia 45, 1613-1622 (2004). ■ Only identified epidemiological study to use a medical database to identify comorbidities using a large sample size.
2. Tellez-Zenteno JF, Matijevic S, Wiebe S: Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia 46, 1955-1962 (2005).
3. Bazil CW: Comprehensive care of the epilepsy patient - control, comorbidity, and cost. Epilepsia 45, 3-12 (2004).
4. Pulsipher DT, Seidenberg M, Jones J, Hermann B: Quality of life and comorbid medical and psychiatric conditions in temporal lobe epilepsy. Epilepsy Behav. 9, 510-514 (2006).
5. Wiebe S, Hesdorffer DC: Epilepsy: being ill in more ways than one. Epilepsy Curr. 7, 145-148 (2007).
6. Boro A, Haut S: Medical comorbidities in the treatment of epilepsy. Epilepsy Behav. 4, S2-S12 (2003).
7. Forsgren L: Prevalence of epilepsy in adults in northern Sweden. Epilepsia 33, 450-458 (1992).
8. Gaitatzis A, Trimble MR, Sander JW: The psychiatric comorbidity of epilepsy. Acta Neurol. Scand. 110, 207-220 (2004).
9. Jalava M, Sillanpaa M: Concurrent illnesses in adults with childhood-onset epilepsy: a population-based 35-year follow-up study. Epilepsia 37, 1155-1163 (1996).
10. Kobau R, Zahran H, Thurman DJ et al.: Epilepsy surveillance among adults - 19 states, behavioral risk factor surveillance system. MMWR Surveill. Summ. 57(6), 1-20 (2008).
11. Strine TW, Kobau R, Chapman DP et al.: Psychological distress, comorbidities, and health behaviors among U.S. adults with seizures: results from the 2002 National Health Interview Survey. Epilepsia 46, 1133-1139 (2005).
12. Davies S, Heyman I, Goodman R: A population survey of mental health problems in children with epilepsy. Dev. Med. Child Neurol. 45, 292-295 (2003).
13. Kobau R, Gilliam F, Thurman DJ: Prevalence of self-reported epilepsy or seizure disorder and its associations with self-reported depression and anxiety: results from the 2004 Healthstyles Survey. Epilepsia 47, 1915-1921 (2006).
14. Tellez-Zenteno JF, Patten SB, Jette N, Williams J, Wiebe S: Psychiatric comorbidity in epilepsy: a population-based ana lysis. Epilepsia 48, 2336-2344 (2007).
15. van Blarikom W, Tan IY, Aldenkamp AP, van Gennep ATG: Epilepsy, intellectual disability, and living environment: a critical review. Epilepsy Behav. 9, 14-18 (2006).
16. Jetter GM, Cavazos JE: Epilepsy in the elderly. Semin. Neurol. 28, 336-341 (2008).
17. Souverein PC, Webb DJ, Weil JG, Van Staa TP, Egberts ACG: Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy. Neurology 66, 1318-1324 (2006).
18. Vestergaard P: Epilepsy, osteoporosis and fracture risk - a meta-ana lysis. Acta Neurol. Scand. 112, 277-286 (2005). ■ Detailed meta-analytic study examining bone health problems in epilepsy and discussion of possible mechanisms.
19. Lado F, Spiegel R, Masur JH, Boro A, Haut SR: Value of routine screening for bone demineralization in an urban population of patients with epilepsy. Epilepsy Res. 78, 155-160 (2008).
20. Elliott JO, Lu B, Moore JL, McAuley JW, Long L: Exercise, diet, health behaviors, and risk factors among persons with epilepsy based on the California Health Interview Survey, 2005. Epilepsy Behav. 13, 307-315 (2008).
21. Rowan AJ: Common morbidities influence development, treatment strategies, and expected outcomes. Geriatrics 60, 30-34 (2005).
22. Bladin CF, Alexandrov AV, Bellavance A et al.: Seizures after stroke: a prospective multicenter study. Arch. Neurol. 57, 1617-1622 (2000).
23. So EL, Annegers JF, Hauser WA, O'Brien PC, Whisnant JP: Population-based study of seizure disorders after cerebral infarction. Neurology 46, 350-355 (1996).
24. Kotila M, Waltimo O: Epilepsy after stroke. Epilepsia 33, 495-498 (1992).
25. Cordonnier C, Henon H, Derambure P, Pasquier F, Leys D: Influence of pre-existing dementia on the risk of post-stroke epileptic seizures. J. Neurol. Neurosurg. Psychiatry 76, 1649-1653 (2005).
26. LaFrance WC, Kanner AM, Hermann B: Psychiatric comorbidities in epilepsy. Int. Rev. Neurobiol. 83, 347-383 (2008). ■■ Extensive and comprehensive review of all psychiatric comorbidities in epilepsy.
27. Schmitz B: Depression and mania in patients with epilepsy. Epilepsia 46, 45-49 (2005).
28. Hermann BP, Seidenberg M, Haltiner A, Wyler AR: Mood state in unilateral temporal lobe epilepsy. Biol. Psychiatry 30, 1205-1218 (1991).
29. Austin JK, Caplan R: Behavioral and psychiatric comorbidities in pediatric epilepsy: toward an integrative model. Epilepsia 48, 1639-1651 (2007). ■■ Comprehensive review of psychological factors and proposal of an integrative model that combines biological factors.
30. Hesdorffer DC, Hauser WA, Annegers JF, Cascino G: Major depression is a risk factor for seizures in older adults. Ann. Neurol. 47, 246-249 (2000).
31. Ekinci O, Titus JB, Rodopman AA, Berkem M, Trevathan E: Depression and anxiety in children and adolescents with epilepsy: prevalence, risk factors, and treatment. Epilepsy Behav. 14, 8-18 (2009).
32. Jones JE, Watson R, Sheth R et al.: Psychiatric comorbidity in children with new onset epilepsy. Dev. Med. Child Neurol. 49, 493-497 (2007).
33. Kanner AM: Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol. Psychiatry 54, 388-398 (2003). ■■ Detailed review of presentation of depression in epilepsy, risk factors and mechanisms.
34. Kanner AM: Epilepsy and mood disorders. Epilepsia 48, 20-22 (2007).
35. Rosche J, Uhlmann C, Froscher W: Low serum folate levels as a risk factor for depressive mood in patients with chronic epilepsy. J. Neuropsychiatry Clin. Neurosci. 15, 64-66 (2003).
36. Ludvigsson P, Hesdorffer D, Olafsson E, Kjartansson O, Hauser WA: Migraine with aura is a risk factor for unprovoked seizures in children. Ann. Neurol. 59, 210-213 (2006).
37. Bigal ME, Lipton RB, Cohen J, Silberstein SD: Epilepsy and migraine. Epilepsy Behav. 4(Suppl. 2), S13-S24 (2003).
38. Scher AI, Bigal ME, Lipton RB: Comorbidity of migraine. Curr. Opin. Neurol. 18, 305-310 (2005).
39. Calabresi P, Galletti F, Rossi C, Sarchielli P, Cupini LM: Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms. Trends Pharmacol. Sci. 28, 188-195 (2007).
40. Gorji A: Spreading depression: a review of the clinical relevance. Brain Res. Brain Res. Rev. 38, 33-60 (2001). ■■ Most extensive review of cortical spreading depression in migraine to date.
41. Rogawski MA: Common pathophysiologic mechanisms in migraine and epilepsy. Arch. Neurol. 65, 709-714 (2008).
42. Gargus JJ: Genetic calcium signaling abnormalities in the central nervous system: seizures, migraine, and autism. Ann. NY Acad. Sci. 1151, 133-156 (2009).
43. Crompton DE, Berkovic SF: The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. Lancet Neurol. 8, 370-381 (2009).
44. Ounsted C: The hyperkinetic syndrome in epileptic children. Lancet 269, 303-311 (1955).
45. Elliott JO, Lu B, Shneker B, Charyton C, Moore JL: Comorbidity, health screening, and quality of life among persons with a history of epilepsy. Epilepsy Behav. 14, 125-129 (2009).
46. Hesdorffer DC, Ludvigsson P, Olafsson E, Gudmundsson G, Kjartansson O, Hauser WA: ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch. Gen. Psychiatry 61, 731-736 (2004).
47. Dunn DW, Austin JK, Harezlak J, Ambrosius WT: ADHD and epilepsy in childhood. Dev. Med. Child Neurol. 45, 50-54 (2003).
48. Hermann B, Jones J, Dabbs K et al.: The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy. Brain 130, 3135-3148 (2007).
49. Sherman EM, Slick DJ, Connolly MB, Eyrl KL: ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia 48, 1083-1091 (2007).
50. McIntyre DC, Gilby KL: Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities. Epilepsia 48(Suppl. 9), 30-32 (2007).
51. Hermann B, Seidenberg M, Sager M et al.: Growing up with epilepsy: the neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsy. Epilepsia 49, 731-740 (2008).
52. Levisohn PM: The autism-epilepsy connection. Epilepsia 48(Suppl. 9), 33-35 (2007).