Changes in UNC5C gene methylation during human gastric carcinogenesis

Anticancer Research

Volumn 29, Issue 11, 2009, Pages 4397-4399

  Hibi, Kenji ^a   Sakata, Makiko ^a   Sakuraba, Kazuma ^a   Kitamura, Yo Hei ^a   Shirahata, Atsushi ^a   Goto, Tetsuhiro ^a   Mizukami, Hiroki ^a   Saito, Mitsuo ^a   Ishibashi, Kazuyoshi ^a   Kigawa, Gaku ^a   Nemoto, Hiroshi ^a   Sanada, Yutaka ^a  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Gastric cancer; Quantitative methylation specific PCR; UNC5C

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; METHYLATION; ONCOGENE; ONCOGENE UNC5C; POLYMERASE CHAIN REACTION; PRIMARY TUMOR; PRIORITY JOURNAL; STOMACH CARCINOMA;

AGED; AGED, 80 AND OVER; DNA METHYLATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; RECEPTORS, CELL SURFACE; STOMACH NEOPLASMS;

EID: 75149198663     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Fuchs CS and Mayer RJ: Gastric carcinoma. N Engl J Med 333: 32-41, 1995.
2. Yasui W, Yokozaki H, Fujimoto J, Naka K, Kuniyasu H and Tahara E: Genetic and epigenetic alterations in multistep carcinogenesis of the stomach. J Gastroenterol 35: 111-115, 2000.
3. Chen W-D, Han ZJ, Skoletsky J, Olson J, Sah J, Myeroff L, Platzer P, Lu S, Dawson D, Willis J, Pretlow TP, Lutterbaugh J, Kasturi L, Willson JKV, Rao JS, Shuber A and Markowitz SD: Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J Natl Cancer Inst 97: 1124-1132, 2005.
4. Leung SY, Yuen ST, Chung LP, Chu KM, Chan AS and Ho JC: hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 59: 159-164, 1999.
5. Oue N, Shigeishi H, Kuniyasu H, Yokozaki H, Kuraoka K, Ito R and Yasui W: Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma. Int J Cancer 93: 805-809, 2001.
6. Kang SH, Choi HH, Kim SG, Jong HS, Kim NK, Kim SJ and Bang YJ: Transcriptional inactivation of the tissue inhibitor of metalloproteinase-3 gene by DNA hypermethylation of the 5′-CpG island in human gastric cancer cell lines. Int J Cancer 86: 632-635, 2000.
7. Shim YH, Kang GH and Ro JY: Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas. Lab Invest 80: 689-695, 2000.
8. Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB and Knowles BB: The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 389: 838-842, 1997.
9. Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M and Stein E: A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97: 927-941, 1999.
10. Llambi F, Causeret F, Bloch-Gallego L and Mehlen P: Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 20: 2715-2722, 2001.
11. Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G and Mehlen P: The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Nat1 Acad Sci USA 100: 4173-4178, 2003.
12. Bernet A, Mazelin L, Coissieux M-M, Gadot N, Ackerman SL, Scoazec J-Y and Mehlen P: Inactivation of the UNC5C netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterol 133: 1840-1848, 2007.
13. Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR and Goel A: Epigenetic and genetic alterations in netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterol 133: 1849-1857, 2007.
14. Hibi K, Mizukami H, Shirahata A, Goto T, Sakata M, Saito M, Ishibashi K, Kigawa G, Nemoto H and Sanada Y: Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer. Anticancer Res 29: 271-273 2009.
15. Hibi K, Taguchi M, Nakayama H, Takase T, Kasai Y, Ito K, Akiyama S and Nakao A: Molecular detection of pl6 promoter methylation in the serum of patients with esophageal squamous cell carcinoma. Clin Cancer Res 7: 3135-3138, 2001.
16. Hibi K, Nakayama H, Kanyama Y, Kodera Y, Ito K, Akiyama S and Nakao A: Methylation pattern of HLTF gene in digestive tract cancers. Int J Cancer 104: 433-436, 2003.
17. Hibi K, Kodera Y, Ito K, Akiyama S and Nakao A: Methylation pattern of CDH13 gene in digestive tract cancers. Br J Cancer 91: 1139-1142, 2004.
18. Hibi K, Robinson CR, Booker S, Wu L, Hamilton SR, Sidransky D and Jen J: Molecular detection of genetic alterations in the serum of colorectal cancer patients. Cancer Res 58: 1405-1407, 1998.
19. Nakayama H, Hibi K, Taguchi M, Takase T, Yamazaki T, Kasai Y, Ito K, Akiyama S and Nakao A: Molecular detection of p16 promoter methylation in the serum of colorectal cancer patients. Cancer Lett 188: 115-119, 2002.