Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes

Diabetes Care

Volumn 33, Issue 2, 2010, Pages 390-395

  Katakami, Naoto ^a   Takahara, Mitsuyoshi ^a   Kaneto, Hideaki ^a   Shimizu, Ikki ^b   Ohno, Keizo ^c   Ishibashi, Fukashi ^d   Osonoi, Takeshi ^e   Kashiwagi, Atsunori ^f   Kawamori, Ryuzo ^g   Shimomura, Iichiro ^a   Matsuhisa, Munehide ^a   Yamasaki, Yoshimitsu ^h  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EHIME PREFECTURAL CENTRAL HOSPITAL   (Japan)

^c Ehime Prefectural Imabari Hospital   (Japan)

^d Ishibashi Clinic   (Japan)

^e Naka Kinen Clinic   (Japan)

^f SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^g JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 12; GELATINASE B; PLASMINOGEN ACTIVATOR INHIBITOR 1; VON WILLEBRAND FACTOR;

ADULT; AGED; ALLELE; ARTICLE; ATHEROSCLEROTIC PLAQUE; BRAIN INFARCTION; DIABETIC PATIENT; DNA POLYMORPHISM; FEMALE; GENETIC ANALYSIS; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL EXAMINATION; PREVALENCE; RISK FACTOR; THROMBOGENESIS; THROMBOSIS;

ADULT; AGED; CEREBRAL INFARCTION; CHOLESTEROL, HDL; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FACTOR XII; FEMALE; GENOTYPE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; JAPAN; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; THROMBOSIS; TRIGLYCERIDES; VON WILLEBRAND FACTOR;

EID: 75149196825     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc09-1518     Document Type: Article

References (23)

1. Hassan A, Markus HS. Genetics and ischaemic stroke. Brain 2000;123:1784-1812
2. Markus H. Genes for stroke. J Neurol Neurosurg Psychiatry 2004;75:1229-1231
3. Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions: association of active enzyme synthesis with unstable angina. Circulation 1995;91:2125-2131
4. Gough PJ, Gomez IG, Wille PT, Raines EW. Macrophage expression of active MMP-9 induces acute plaque disruption in apo E-deficient mice. J Clin Invest 2006;116:59-69
5. Konstantino Y, Nguyen TT, Wolk R, Aiello RJ, Terra SG, Fryburg DA. Potential imolications of matrix metalloproteinase-9 in assessment and treatment of coronary artery disease. Biomarkers 2009; 14:118-129
6. Zhang B, Ye S, Herrmann SM, Eriksson P, de Maat M, Evans A, Arveiler D, Luc G, Cambien F, Hamsten A, Watkins H, Henney AM. Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation 1999;99:1788-1794
7. Blankenberg S, Rupprecht HJ, Poirier O, Bickel C, Smieja M, Hafner G, Meyer J, Cambien F, Tiret L, the AtheroGene Investigators. Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation 2003; 107:1579-1585
8. Miller GJ, Esnouf MP, Burgess AI, Cooper JA, Mitchell JP. Risk of coronary heart disease and activation of factor XII in middleaged men. Arterioscler Thromb Vasc Biol 1997;17:2103-2106
9. Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood 2008;112: 3555-3562
10. Kanaji T, Okamura T, Osaki K, Kuroiwa M, Shimoda K, Hamasaki N, Niho Y. A common genetic polymorphism (46 C to T substitution) in the 5-prime-untranslated region of the coagulation factor XII gene is associated with low translation ef-ficiency and decrease in plasma factor XII level. Blood 1998;91:2010-2014
11. Kohler HP, Futers TS, Grant PJ. FXII (46C3T) polymorphism and in vivo generation of FXII activity-gene frequencies and relationship in patients with coronary artery disease. Thromb Haemos 1999;81: 745-747
12. Spiel AO, Gilbert JC, Jilma B. von Willebrand factor in cardiovascular disease: focus on acute coronary syndromes. Circulation 2008;117:1449-1459
13. Keightley AM, Lam YM, Brady JN, Cameron CL, Lillicrap D. Variation at the von Willebrand factor (vWF) gene locus is associated with plasma vWF:Ag levels: identification of three novel single nucleotide polymorphisms in the vWF gene promoter. Blood 1999;93:4277-4283
14. Dawson S, Wiman B, Hamsten A, Green F, Humphries S, Henney AM. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem 1993;268: 10739-10745
15. Cho HJ, Chae IH, Park KW, Ju JR, Oh S, Lee MM, Park YB. Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention. J Hum Genet 2002;47:88-91
16. Abilleira S, Bevan S, Markus HS. The role of genetic variants of matrix metalloproteinases in coronary and carotid atherosclerosis. J Med Genet 2006;43: 897-901
17. Endler G, Mannhalter C, Sunder-Plassmann H, Lalouschek W, Kapiotis S, Exner M, Jordanova N, Meier S, Kunze F, Wagner O, Huber K. Homozygosity for the C-T polymorphism at nucleotide 46 in the 5-prime untranslated region of the factor XII gene protects from development of acute coronary syndrome. Br J Haemat 2001;115:1007-1009
18. Santamaría A, Mateo J, Tirado I, Oliver A, Belvís R, Martí-Fábregas J, Felices R, Soria JM, Souto JC, Fontcuberta J. Homozygosity of the T allele of the 46 C3T polymorphism in the F12 gene is a risk factor for ischemic stroke in the Spanish population. Stroke 2004;35:1795-1799
19. Oguchi S, Ito D, Murata M, Yoshida T, Tanahashi N, Fukuuchi Y, Ikeda Y, Watanabe K. Genotype distribution of the 46 C/T polymorphism of coagulation factor XII in the Japanese population: absence of its association with ischemic cerebrovascular disease. Thromb Haemost 2000;83: 178-179
20. Bitondo R, Cameron CL, Daly ME, Croft SA, Steeds RP, Channer KS, Samani NJ, Lillicrap D, Winship PR. The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction. Br J Haematology 2001;115:701-706
21. Simmonds RE, Hermida J, Rezende SM, Lane DA. Haemostatic genetic risk factors in arterial thrombosis. Thromb Haemost 2001;86:374-385
22. Ye Z, Liu EH, Higgins JP, Keavney BD, Lowe GD, Collins R, Danesh J. Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet 2006;367:651-658
23. Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, Sone T, Tanaka M, Yokota M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 2002;347:1916-1923