No effect of a homoeopathic combination of Arnica montana and Bryonia alba on bleeding, inflammation, and ischaemia after aortic valve surgery

British Journal of Clinical Pharmacology

Volumn 69, Issue 2, 2010, Pages 136-142

  Cornu, Catherine ^a,b,c,d   Joseph, Pierre ^a,e,f   Gaillard, Ségolène ^a,b,c,d   Bauer, Christian ^a,e,f   Vedrinne, Catherine ^a,e,f   Bissery, Alvine ^b,c,d,f   Melot, Ghislaine ^a,b,c,d   Bossard, Nadine ^c   Belon, Philippe ^d   Lehot, Jean Jacques ^a,e,f  

^a INSERM   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c UNIVERSITÉ DE LYON   (France)

^d LABORATOIRE DE BIOMÉTRIE ET BIOLOGIE EVOLUTIVE   (France)

^e LOUIS PRADEL HOSPITAL   (France)

^f UNIVERSITÉ LYON 1   (France)

Author keywords

Cardiac surgery; Cardiopulmonary bypass; Homoeopathic treatment; Inflammation; Myocardial ischaemia

Indexed keywords

C REACTIVE PROTEIN; HERBACEOUS AGENT; HOMEOPATHIC AGENT; PLACEBO; TROPONIN C; PLANT EXTRACT;

ADULT; AGED; AORTA VALVE REPLACEMENT; ARNICA MONTANA; ARTICLE; BLEEDING; BODY TEMPERATURE; BRYONIA; BRYONIA ALBA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DELIRIUM; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG FATALITY; ERYTHROCYTE CONCENTRATE; FEMALE; HEALING; HEART ARRHYTHMIA; HEART MUSCLE INJURY; HEMATOCRIT; HUMAN; INFLAMMATION; ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MOOD DISORDER; NOCICEPTION; PERICARDIAL EFFUSION; PERIOPERATIVE PERIOD; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STERNOTOMY; STROKE; TREATMENT OUTCOME; AORTA VALVE; ARNICA; HEART SURGERY; HEMORRHAGE; HOMEOPATHY; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PAIN, POSTOPERATIVE; PHYTOTHERAPY; POSTOPERATIVE COMPLICATIONS; PROCEDURES; REGRESSION ANALYSIS; SURGERY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AORTIC VALVE; ARNICA; BRYONIA; CARDIAC SURGICAL PROCEDURES; DOUBLE-BLIND METHOD; FEMALE; HEMORRHAGE; HOMEOPATHY; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PAIN, POSTOPERATIVE; PHYTOTHERAPY; PLANT EXTRACTS; POSTOPERATIVE COMPLICATIONS; POSTOPERATIVE HEMORRHAGE; REGRESSION ANALYSIS; TREATMENT OUTCOME;

EID: 75149188354     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2009.03574.x     Document Type: Article

References (19)

1. Robbers JE, Tyler VE, eds. Tyler's Herbs of Choice: the Therapeutic Use of Phytomedicinals. Binghamton, NY : Haworth Herbal Press, 1999.
2. Ernst E, Pittler MH. Efficacy of homeopathic arnica. Arch Surg 1998 133 : 1187 1190.
3. Hart O, Mullee MA, Lewith G, Miller J. Double-blind, placebo-controlled, randomized clinical trial of homeopathic arnica C30 for pain and infection after total abdominal hysterectomy. J R Soc Med 1997 90 : 73 8.
4. Ramelet AA, Buchheim G, Lorenz P, Imfeld M. Homeopathic arnica in postoperative haematomas: a double-blind study. Dermatology 2000 201 : 347 348.
5. Stevinson C, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. J R Soc Med 2003 96 : 60 5.
6. Seeley BM, Denton AB, Ahn MS, Maas CS. Effect of homeopathic Arnica montana on bruising in face-lifts. Arch Facial Plast Surg 2006 8 : 54 9.
7. Paris A, Gonnet N, Chaussard C, Belon P, Rocourt F, Saragaglia D, Cracowski JL. Effect of homeopathy on analgesic intake following knee ligament reconstruction: a phase III monocentre randomized placebo controlled study. Br J Clin Pharmacol 2008 65 : 180 187.
8. Oberbaum M, Galoyan N, Lerner-Geva L, Singer S, Grisaru S, Shashar D, Samueloff A. The effect of the homeopathic remedies Arnica montana and Bellis perennis on mild postpartum bleeding - a randomized, double-blind, placebo-controlled study - preliminary results. Complement Ther Med 2005 13 : 87 90.
9. Berrebi A, Parant O, Ferval F, Thene M, Ayoubi JM, Connan L, Belon P. [Treatment of pain due to unwanted lactation with a homeopathic preparation given in the immediate post-partum period]. J Gynecol Obstet Biol Reprod (Paris) 2001 30 : 353 357.
10. Aouifi A, Piriou V, Blanc P, Bouvier H, Bastien O, Chiari P, Rousson R, Evans R, Lehot JJ. Effect of cardiopulmonary bypass on serum procalcitonin and C-reactive protein concentrations. Br J Anaesth 1999 83 : 602 607.
11. Mojcik CF, Levy JH. Aprotinin and the systemic inflammatory response after cardiopulmonary bypass. Ann Thorac Surg 2001 71 : 745 754.
12. Levi M, Cromheecke ME, de Jonge E, Prins MH, de Mol BJ, Briët E, Büller HR. Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints. Lancet 1999 354 : 1940 1947.
13. Bézanger-Beauquesne L, Pinkas M, Torck M, Trotin F. Plantes Médicinales Des Régions Tempérées. Paris : Maloine S.A., 1980.
14. Jouanny J. Notions Essentielles De Matière Médicale Homéopathique. Lyon : Laboratoires Boiron, 1980.
15. Zissu R, Guillaume M. Fiches De Matière Médicale Homéopathique. Lyon : BOIRON France, 1999.
16. Demarque D, Jouanny J, Poitvin B, Saint-Jean Y. Homéopathie Connaître La Matière Médicale. Lyon : CEDH, 1989.
17. Berrebi A, Parant O, Ferval F, Thene M, Ayoubi JM, Connan L, Belon P. Traitement de la douleur de la montée laiteuse non souhaitée par homéopathie dans le post-partum immédiat. J Gynecol Obstet Biol Reprod (Paris) 2001 30 : 353 357.
18. Kouzi SA, Nuzum DS. Arnica for bruising and swelling. Am J Health Syst Pharm 2007 64 : 2434 2443.
19. Jonas W, Lin Y, Williams A, Tortella F, Tuma R. Treatment of experimental stroke with low-dose glutamate and homeopathic Arnica montana. Perfusion 1999 12 : 452 462.