Vascular cell-like potential of undifferentiated ligament fibroblasts to construct vascular cell-specific marker-positive blood vessel structures in a PI3K activation-dependent manner

Journal of Vascular Research

Volumn 47, Issue 5, 2010, Pages 369-383

  Okubo, Naoto ^a,b   Ishisaki, Akira ^a   Iizuka, Tadashi ^b   Tamura, Masato ^a   Kitagawa, Yoshimasa ^b  

^a Department of Oral Biochemistry and Molecular Biology   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Differentiation; Endothelial cell; Fibroblast growth factor; Fibroblasts; FLK 1; Periodontal ligament; PI3K; Three dimensional vessel reconstruction; Tie 2

Indexed keywords

ANGIOPOIETIN RECEPTOR; COLLAGEN TYPE 1; MOLECULAR SCAFFOLD; PHOSPHATIDYLINOSITOL 3 KINASE; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL; CELL CULTURE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBROBLAST; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL; NONHUMAN; PERIODONTAL LIGAMENT; PRIORITY JOURNAL; RAT; VASCULAR CELL; VASCULARIZATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD VESSELS; CELL LINEAGE; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; FIBROBLASTS; MALE; MESENCHYMAL STEM CELLS; PERIODONTAL LIGAMENT; RATS; RATS, WISTAR; RECEPTOR, TIE-2; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 75149170591     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000277724     Document Type: Article

References (34)

1. Hou LT, Yaeger JA: Cloning and characterization of human gingival and periodontal ligament fibroblasts. J Periodontol 1993; 64: 1209-1218.
2. McCulloch CA: Progenitor cell populations in the periodontal ligament of mice. Anat Rec 1985; 211:258-262.
3. Pitaru S, Pritzki A, Bar-Kana I, Grosskopf A, Savion N, Narayanan AS: Bone morphoge-netic protein 2 induces the expression of ce-mentum attachment protein in human peri-odontal ligament clones. Connect Tissue Res 2002; 43:257-264.
4. Nakamura T, Yamamoto M, Tamura M, Izu-mi Y: Effects of growth/differentiation fac-tor-5 on human periodontal ligament cells. J Periodontal Res 2003; 38:597-605.
5. Trubiani O, Isgro A, Zini N, Antonucci I, Aiuti F, Di Primio R, Nanci A, Caputi S, Pa-ganelli R: Functional interleukin-7/inter-leukin-7Ra, and SDF-1a/CXCR4 are expressed by human periodontal ligament derived mesenchymal stem cells. J Cell Physiol 2008; 214:706-713.
6. Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S: The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthod Craniofac Res 2005; 8: 191-199.
7. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S: Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004; 364: 149-155.
8. Shirai K, Ishisaki A, Kaku T, Tamura M, Fu-ruichi Y: Multipotency of clonal cells derived from swine periodontal ligament and differential regulation by fibroblast growth factor and bone morphogenetic protein. J Periodontal Res, in press.
9. Narmoneva DA, Oni O, Sieminski AL, Zhang S, Gertler JP, Kamm RD, Lee RT: Self-assembling short oligopeptides and the promotion of angiogenesis. Biomaterials 2005; 26: 4837-4846.
10. Davis ME, Motion JP, Narmoneva DA, Taka-hashi T, Hakuno D, Kamm RD, Zhang S, Lee RT: Injectable self-assembling peptide nano-fibres create intramyocardial microenviron-ments for endothelial cells. Circulation 2005; 111:442-450.
11. Penta K, Varner JA, Liaw L, Hidai C, Shatzman R, Quertermous T: Del1 induces integrin signaling and angiogenesis by ligation of aV|33. J Biol Chem 1999; 274:11101-11109.
12. 1. Arterioscler Thromb Vasc Biol 2002; 22:69-75.
13. Zhang Y, Hu X, Tian R, WeiW, Hu W, Chen X, Han W, Chen H, Gong Y: Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratino-cytes, fibroblasts, and endothelial cells through interaction with RGD-binding inte-grins. Biochem Biophys Res Commun 2006; 347:100-108.
14. Ingham KC, Brew SA, Migliorini M: Type I collagen contains at least 14 cryptic fibro-nectin binding sites of similar affinity. Arch Biochem Biophys 2002, 407: 217-223.
15. Ibi M, Ishisaki A, Yamamoto M, WadaS, Ko-zakai T, Nakashima A, Iida J, Takao S, Izumi Y, Yokoyama A, Tamura M: Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments. Arch Oral Biol 2007; 52:1002-1008.
16. Li H, Zhou J, Miki J, Furusato B, Gu Y, Sri-vastava S, McLeod DG, Vogel JC, Rhim JS: Telomerase-immortalised non-malignant human prostate epithelial cells retain the properties of multipotent stem cells. Exp Cell Res 2008;314:92-102.
17. Murphy DA, Makonnen S, Lassoued W, Feldman MD, Carter C, Lee WM: Inhibition of tumor endothelial ERK activation, angio-genesis, and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006; 169:1875-1885.
18. Yang YH, Wang Y, Lam KS, Cheng KK, Zhang J, Zhu W, Wu D, Xu A: Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carbpxyl terminus of angiopoietin-like protein 4. Arte-rioscler Thromb Vasc Biol 2008; 28:835-840.
19. Shankar S, Chen Q, Srivastava RK: Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogen-ic effects of EGCG through activation of FOXO transcription factor. J Mol Signal 2008; 3: 7.
20. Harmer NJ: Insights into the role of heparan sulphate in fibroblast growth factor signaling. Biochem Soc Trans 20 06; 34: 442-445.
21. Alajati A, Laib AM, Weber H, Boos AM, Bar-tol A, Kristian I, Korff T, Zentgraf H, Obodozie C, Graeser R, Chiristian S, Finken-zeller G, Stark GB, Héroult M, Augustin HG: Spheroid-based engineering of a human vas-culature in mice. Nat Methods 2008; 5:439-445.
22. Ishiyama M, Miyazono Y, Sakamoto K, Oh-kuma Y, Ueno K: A highly water-soluble di-sulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability. Taranta 1997; 44:1299-1305.
23. Gabrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119:493-501.
24. Giannopoulou C, Cimasoni G: Functional characteristics of gingival and periodontal ligament fibroblasts. J Det Res 1996; 75: 895-902.
25. Ivanovski S, Gronthos S, Shi S, Bartold PM: Stem cells in the periodontal ligament. Oral Dis 2006; 12: 35 8-3 63.
26. Gronthos S, Mankani M, Brahim J, Robey PG, and Shi S: Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. PNAS 2000; 97:13625-13630.
27. Baksh D, Yao R, Tuan RS: Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 2008; 25:1384-1392.
28. Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Ne-grini M, Peschle C, Valtieri M: Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp Hematol 2008; 30: 1035-10 46.
29. Fujii S, Maeda H, Wada N, Tomikiyo A, Saito M, Akamine A: Investigating a clonal human periodontal ligament progenitor/stem cell line in vitro and in vivo. J Cell Physiol 2008; 215:743-749. (Pubitemid 351632696)
30. Bogdanovic E, Nguyen VP, Dumont DJ: Activation of Tie2 by angiopoietin-1 and angio-poietin-2 results in their release and receptor internalization. J. Cell Sci 2006; 119: 3551-3560.
31. Tsutsumi S, Shimazu A, Miyazaki K, Pan H, Koike C, Yoshida E, Takagishi K, Kato Y: Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun 20 01; 288: 413-419.
32. Yamashita J, Itoh H, Hirashima M, Ogawa M, Nishikawa S, Yugiri T, Naito M, Nakao K, Nishikawa S: Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 2000; 408: 92-96.
33. Ishisaki A, Hayashi H, Li AJ, Imamura T: Human umbilical vein endothelium-derived cells retain potential to differentiate into smooth muscle-like cells. J Biol Chem 2003; 278:1303-1309.
34. Bartold PM, Shi S, Gronthos S: Stem cells and periodontal regeneration. Periodontol 2000 2006; 40: 164-172.