The efficacy and safety of gonadotropin-releasing hormone analog treatment in childhood and adolescence: A single center, long-term follow-up study

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 1, 2010, Pages 109-117

  Magiakou, Maria Alexandra ^a   Manousaki, Despoina ^a   Papadaki, Marina ^b   Hadjidakis, Dimitrios ^a   Levidou, Georgia ^a   Vakaki, Marina ^b   Papaefstathiou, Athanassios ^a   Lalioti, Niki ^a   Kanaka Gantenbein, Christina ^a   Piaditis, George ^c   Chrousos, George P ^a   Dacou Voutetakis, Catherine ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b P AND A KYRIAKOU CHILDREN S HOSPITAL   (Greece)

^c KAT HOSPITAL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GROWTH HORMONE; LUTEINIZING HORMONE; TRIPTORELIN;

ADOLESCENT; ADULT; ARTICLE; BEDTIME DOSAGE; BODY COMPOSITION; BODY HEIGHT; BODY MASS; BONE DENSITY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FEMALE; GROWTH HORMONE DEFICIENCY; HIRSUTISM; HUMAN; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OVARY FUNCTION; OVARY POLYCYSTIC DISEASE; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; SHORT STATURE;

EID: 75149156935     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0793     Document Type: Article

References (39)

1. Klein KO, Barnes KM, Jones JV, Feuillan PP, Cutler Jr GB 2001 Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience. J Clin Endocrinol Metab 86: 4711-4716
2. Lazar L, Padoa A, Phillip M 2007 Growth pattern and final height after cessation of gonadotropin-suppressive therapy in girls with central sexual precocity. J Clin Endocrinol Metab 92:3483-3489
3. Cassio A, Cacciari E, Balsamo A, Bal M, Tassinari D 1999 Randomised trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7.5-8.5 years. Arch Dis Child 81:329-332
4. Lazar L, Kauli R, Pertzelan A, Phillip M 2002 Gonadotropin- suppressive therapy in girls with early and fast puberty affects the pace of puberty but not total pubertal growth or final height. J Clin Endocrinol Metab 87:2090-2094
5. Mericq MV, Eggers M, Avila A, Cutler Jr GB, Cassorla F 2000 Near final height in pubertal GH-deficient patients treated with GH alone or in combination with LHRHa: results of a prospective, randomized trial. J Clin Endocrinol Metab 85:569-573
6. Yanovski JA, Rose SR, Municchi G, Pescovitz OH, Hill SC, Cassorla FG, Cutler Jr GB 2003 Treatment with a luteinizing hormone-releasing hormone agonist in adolescents with short stature. N Engl J Med 348: 908-917
7. Adan L, Chemaitilly W, Trivin C, Brauner R 2002 Factors predicting adult height in girls with idiopathic central precocious puberty: implications for treatment. Clin Endocrinol (Oxf) 56:297-302
8. Bouvattier C, Coste J, Rodrigue D, Teinturier C, Carel JC, Chaussain JL, Bougnères PF 1999 Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study. J Clin Endocrinol Metab 84:3575-3578
9. Antoniazzi F, Arrigo T, Cisternino M, Galluzzi F, Bertelloni S, Pasquino AM, Borrelli P, Osio D, Mengarda F, De Luca F, Tatò L 2000 End results in central precocious puberty with GnRH analog treatment: the data of the Italian Study Group for Physiopathology of Puberty. J Pediatr Endocrinol Metab 13(Suppl 1):773-780
10. Heger S, Partsch CJ, Sippell WG 1999 Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metab [Erratum (2000) 85:657] 84:4583-4590
11. Pasquino AM, Pucarelli I, Accardo F, Demiraj V, Segni M, Di Nardo R 2008 Long-term observation of 87 girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogs: impact on adult height, body mass index, bone mineral content, and reproductive function. J Clin Endocrinol Metab 93: 190-195
12. Palmert MR, Mansfield MJ, Crowley Jr WF, Crigler Jr JF, Crawford JD, Boepple PA 1999 Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. J Clin Endocrinol Metab 84:4480-4488
13. Traggiai C, Perucchin PP, Zerbini K, Gastaldi R, De Biasio P, Lorini R 2005 Outcome after depot gonadotrophin-releasing hormone agonist treatment for central precocious puberty: effects on body mass index and final height. Eur J Endocrinol 153:463-464
14. Saggese G, Bertelloni S, Baroncelli GI, Battini R, Franchi G 1993 Reduction of bone density: an effect of gonadotropin releasing hormone analogue treatment in central precocious puberty. Eur J Pediatr 152:717-720
15. van der Sluis IM, Boot AM, Krenning EP, Drop SL, de Muinck Keizer-Schrama SM 2002 Longitudinal follow-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin Endocrinol Metab 87:506-512
16. Antoniazzi F, Bertoldo F, Zamboni G, Valentini R, Sirpresi S, Cavallo L, Adami S, Tatò L 1995 Bone mineral metabolism in girls with precocious puberty during gonadotrophin-releasing hormone agonist treatment. Eur J Endocrinol 133:412-417
17. Boot AM, De Muinck Keizer-Schrama S, Pols HA, Krenning EP, Drop SL 1998 Bone mineral density and body composition before and during treatment with gonadotropin-releasing hormone agonist in children with central precocious and early puberty. J Clin Endocrinol Metab 83:370-373
18. Antoniazzi F, Bertoldo F, Lauriola S, Sirpresi S, Gasperi E, Zamboni G, Tatò L 1999 Prevention of bone demineralization by calcium supplementation in precocious puberty during gonadotropin-releasing hormone agonist treatment. J Clin Endocrinol Metab 84:1992-1996
19. Cassio A, Bal MO, Orsini LF, Balsamo A, Sansavini S, Gennari M, De Cristofaro E, Cicognani A 2006 Reproductive outcome in patients treated and not treated for idiopathic early puberty: long-term results of a randomized trial in adults. J Pediatr 149:532-536
20. Arrigo T, De Luca F, Antoniazzi F, Galluzzi F, Iughetti L, Pasquino AM, Salerno MC, Marseglia L, Crisafulli G 2007 Menstrual cycle pattern during the first gynecological years in girls with precocious puberty following gonadotropin-releasing hormone analogue treatment. Eur J Pediatr 166:73-74
21. Marshall WA, Tanner JM 1969 Variations in the pattern of pubertal changes in girls. Arch Dis Child 44:291-303
22. Greulich W, Pyle I 1959 Radiographic atlas of skeletal development of the hand and wrist. 2nd ed. Stanford, CA: Stanford University Press
23. Tanner JM, Goldstein H, Whitehouse RH 1970 Standards for children's height at ages 2 to 9 years allowing for height of parents. Arch Dis Child 45:755-762
24. Bayley N, Pinneau SR 1952 Tables for predicting adult height for skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr 40:423-441
25. Ferriman D, Gallwey JD 1961 Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 21:1440-1447
26. Fredriks AM, van Buuren S, Fekkes M, Verloove-Vanhorick SP, Wit JM 2005 Are age references for waist circumference, hip circumference and waist-hip ratio in Dutch children useful in clinical practice? Eur J Pediatr 164:216-222
27. Allard P, Delvin EE, Paradis G, Hanley JA, O'Loughlin J, Lavallée C, Levy E, Lambert M 2003 Distribution of fasting plasma insulin, free fatty acids, and glucose concentrations and of homeostasis model assessment of insulin resistance in a representative sample of Québec children and adolescents. Clin Chem 49:644-649
28. Salardi S, Orsini LF, Cacciari E, Bovicelli L, Tassoni P, Reggiani A 1985 Pelvic ultrasonography in premenarcheal girls: relation to puberty and sex hormone concentration. Arch Dis Child 60:120-125
29. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group 2004 Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41-47
30. Faulkner RA, Bailey DA, Drinkwater DT, McKay HA, Arnold C, Wilkinson AA 1996 Bone densitometry in Canadian children 8-17 years of age. Calcif Tissue Int 59:344-351
31. Kröger H, Vainio P, Nieminem J, Kotaniemi A 1995 Comparison of different models for interpreting bone mineral density measurements using DXA and MRI technology. Bone 17:157-159
32. Chiotis D, Tsiftis G, Hatzisymeaon M, Maniati-Christidi M, Krikos X, Dacou-Voutetakis A 2003 Height and weight in subjects of Hellenic origin aged 0-18 years (2000-2001): comparison to a previous study of 1978-1979. Ann Cli Pediatr Univ Atheniensis 50:136-155
33. Chiotis D, Krikos X, Tsiftis G, Hatzisymeaon M, Maniati-Christidi M, Dacou-Voutetakis A 2004 Body mass index and prevalence of obesity in subjects of Hellenic origin aged 0-18 years, living in the Athens area. Ann Cli Pediatr Univ Atheniensis 51:139-154
34. Arrigo T, De Luca F, Antoniazzi F, Galluzzi F, Segni M, Rosano M, Messina MF, Lombardo F 2004 Reduction of baseline body mass index under gonadotropin-suppressive therapy in girls with idiopathic precocious puberty. Eur J Endocrinol 150:533-537
35. Boepple PA 1994 Gonadotropin-releasing hormone agonist therapy of central precocious puberty: growth patterns, final heights and completion of puberty following discontinuation of treatment. In: Savage MO, Bourguignon J-P, Grossman AB, eds. Frontiers in paediatric neuroendocrinology. Oxford, London, Edinburgh, Cambridge, Carlton: Blackwell; 23-29
36. Bridges NA, Cooke A, Healy MJ, Hindmarsh PC, Brook CG 1995 Ovaries in sexual precocity. Clin Endocrinol (Oxf) 42:135-140
37. Jensen AM, Brocks V, Holm K, Laursen EM, Müller J 1998 Central precocious puberty in girls: internal genitalia before, during, and after treatment with long-acting gonadotropin-releasing hormone analogues. J Pediatr 132:105-108
38. Franceschi R, Gaudino R, Marcolongo A, Gallo MC, Rossi L, Antoniazzi F, Tatò L 2009 Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty. Fertil Steril doi:10.1016/j.fernstert.2008.11.016
39. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF 2006 Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 91:4237-4245