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Volumn 15, Issue 6, 2009, Pages 494-501

Evolving role of novel agents for maintenance therapy in myeloma

Author keywords

Bortezomib; Consolidation; Lenalidomide; Maintenance; Multiple myeloma; Thalidomide

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; ANTINEOPLASTIC AGENT; BORTEZOMIB; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; LENALIDOMIDE; MELPHALAN; PAMIDRONIC ACID; PLACEBO; PREDNISOLONE; PREDNISONE; STEROID; THALIDOMIDE; VINCRISTINE;

EID: 75149135755     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e3181c51f24     Document Type: Review
Times cited : (7)

References (32)
  • 1
    • 0036566201 scopus 로고    scopus 로고
    • Maintenance therapy with alternate day prednisone improves survival in multiple myeloma patients
    • Berenson JR, Crowley JJ, Grogan TM, et al. Maintenance therapy with alternate day prednisone improves survival in multiple myeloma patients. Blood. 2002;99:3163-3168.
    • (2002) Blood , vol.99 , pp. 3163-3168
    • Berenson, J.R.1    Crowley, J.J.2    Grogan, T.M.3
  • 2
    • 33845899121 scopus 로고    scopus 로고
    • A randomised comparison of melphalan with prednisone or dexamethasone as induction therapy and dexamethasone or observation as maintenance therapy in multiple myeloma
    • Shustik C, Belch A, Robinson S, et al. A randomised comparison of melphalan with prednisone or dexamethasone as induction therapy and dexamethasone or observation as maintenance therapy in multiple myeloma. Br J Hematol. 2006;136:203-211.
    • (2006) Br J Hematol , vol.136 , pp. 203-211
    • Shustik, C.1    Belch, A.2    Robinson, S.3
  • 3
    • 33646591114 scopus 로고    scopus 로고
    • A randomized trial of maintenance therapy with intron A following high dose melphalan and ABMT in myeloma
    • Cunnigham D, Powles R, Malpas JS, et al. A randomized trial of maintenance therapy with intron A following high dose melphalan and ABMT in myeloma. Br J Haematol. 1998;102:195-202.
    • (1998) Br J Haematol , vol.102 , pp. 195-202
    • Cunnigham, D.1    Powles, R.2    Malpas, J.S.3
  • 4
    • 33644920953 scopus 로고    scopus 로고
    • Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: Final results of phase III US inter group trial S9321
    • Barlogie B, Kyle RA, Anderson KC, et al. Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: final results of phase III US intergroup trial S9321. J Clin Oncol. 2006;24:929-936.
    • (2006) J Clin Oncol , vol.24 , pp. 929-936
    • Barlogie, B.1    Kyle, R.A.2    Anderson, K.C.3
  • 5
    • 33751164196 scopus 로고    scopus 로고
    • Maintenance therapy with thalidomide improves survival in multiple myeloma patients
    • Attal M, Harousseau JL, Leyvraz S, et al. Maintenance therapy with thalidomide improves survival in multiple myeloma patients. Blood. 2006;15: 3289-3294.
    • (2006) Blood , vol.15 , pp. 3289-3294
    • Attal, M.1    Harousseau, J.L.2    Leyvraz, S.3
  • 6
    • 54049148621 scopus 로고    scopus 로고
    • Thalidomide arm of Total Therapy II improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities
    • Barlogie B, Pineda-Roman M, van Rhee F, et al. Thalidomide arm of Total Therapy II improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities. Blood. 2008;112:3115-3121.
    • (2008) Blood , vol.112 , pp. 3115-3121
    • Barlogie, B.1    Pineda-Roman, M.2    Van Rhee, F.3
  • 7
    • 34848928411 scopus 로고    scopus 로고
    • Thalidomide maintenance following high-dose therapy in multiple myeloma: A UK myeloma forum phase II
    • Feyler S, Rawstron A, Jackson G, et al. Thalidomide maintenance following high-dose therapy in multiple myeloma: a UK myeloma forum phase II. Br J Hematol. 2007;139:429-433.
    • (2007) Br J Hematol , vol.139 , pp. 429-433
    • Feyler, S.1    Rawstron, A.2    Jackson, G.3
  • 8
    • 60849114852 scopus 로고    scopus 로고
    • Maintenance thalidomide may improve progression free but not overall survival; Results form the myeloma IX maintenance randomisation
    • Morgan GJ, Jackson GH, Davies FE, et al. Maintenance thalidomide may improve progression free but not overall survival; results form the myeloma IX maintenance randomisation. Blood. 2008;112:656.
    • (2008) Blood , vol.112 , pp. 656
    • Morgan, G.J.1    Jackson, G.H.2    Davies, F.E.3
  • 9
    • 64649083365 scopus 로고    scopus 로고
    • Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure
    • Spencer A, Prince HM, Roberts AW, et al. Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure. J Clin Oncol. 2009;27:1788-1793.
    • (2009) J Clin Oncol , vol.27 , pp. 1788-1793
    • Spencer, A.1    Prince, H.M.2    Roberts, A.W.3
  • 10
    • 70249097029 scopus 로고    scopus 로고
    • Phase II study of thalidomide plus dexamethasone induction followed by tandem melphalan-based autotransplantation and thalidomide-plus-prednisone maintenance for untreated multiple myeloma: A Southwest Oncology group trial (S0204)
    • Hussein MA, Bolejack V, Zonder JA. Phase II study of thalidomide plus dexamethasone induction followed by tandem melphalan-based autotransplantation and thalidomide-plus-prednisone maintenance for untreated multiple myeloma: a Southwest Oncology group trial (S0204). J Clin Oncol. 2009;27:1-8.
    • (2009) J Clin Oncol , Issue.27 , pp. 1-8
    • Hussein, M.A.1    Bolejack, V.2    Zonder, J.A.3
  • 11
    • 58849121835 scopus 로고    scopus 로고
    • Thalidomide-dexamethasone versus Interferon-alphadexamethasone as maintenance treatment after ThaDD induction for multiple myeloma: A prospective, multi centre, randomised study
    • Offidani M, Corvatta L, Polloni C, et al. Thalidomide-dexamethasone versus Interferon-alphadexamethasone as maintenance treatment after ThaDD induction for multiple myeloma: a prospective, multicentre, randomised study. Br J Hematol. 2008;144:653-659.
    • (2008) Br J Hematol , vol.144 , pp. 653-659
    • Offidani, M.1    Corvatta, L.2    Polloni, C.3
  • 12
    • 54049135250 scopus 로고    scopus 로고
    • Oral melphalan, prednisone and thalidomide in elderly patients with multiple myeloma: Updated results of a randomized control trial
    • Palumbo A, Bringhen S, Liberati AM, et al. Oral melphalan, prednisone and thalidomide in elderly patients with multiple myeloma: updated results of a randomized control trial. Blood. 2008;112:3107-3114.
    • (2008) Blood , vol.112 , pp. 3107-3114
    • Palumbo, A.1    Bringhen, S.2    Liberati, A.M.3
  • 13
    • 60849131974 scopus 로고    scopus 로고
    • Melphalan + prednisone versus melphalan + prednisone + thalidomide in induction therapy for multiple myeloma in elderly patients: Final analysis of the dutch cooperative group HOVON 49 study
    • Wijermans P, Schaafsma P, van Norden P, et al. Melphalan + prednisone versus melphalan + prednisone + thalidomide in induction therapy for multiple myeloma in elderly patients: final analysis of the dutch cooperative group HOVON 49 study. Blood. 2008;112:649.
    • (2008) Blood , vol.112 , pp. 649
    • Wijermans, P.1    Schaafsma, P.2    Van Norden, P.3
  • 14
    • 34848833957 scopus 로고    scopus 로고
    • Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM99-06) a randozmized trial
    • Facon T, Mary JY, Hulin C, et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM99-06) a randozmized trial. Lancet. 2007;370:1209-1218.
    • (2007) Lancet , vol.370 , pp. 1209-1218
    • Facon, T.1    Mary, J.Y.2    Hulin, C.3
  • 15
    • 68949137225 scopus 로고    scopus 로고
    • Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial
    • Hulin C, Facon T, Rodon P, et al. Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial. J Clin Oncol. 2009;27:3664-3670.
    • (2009) J Clin Oncol , vol.27 , pp. 3664-3670
    • Hulin, C.1    Facon, T.2    Rodon, P.3
  • 16
    • 65349142006 scopus 로고    scopus 로고
    • Thalidomide-dexamethasone compared with melphalan-prednisone in elderly patients with multiple myeloma
    • Ludwig H, Hajek R, Tothova E, et al. Thalidomide-dexamethasone compared with melphalan-prednisone in elderly patients with multiple myeloma. Blood. 2009;113:3435-3442.
    • (2009) Blood , vol.113 , pp. 3435-3442
    • Ludwig, H.1    Hajek, R.2    Tothova, E.3
  • 17
    • 0032042194 scopus 로고    scopus 로고
    • MRC trial of alpha-2b-interferon maintenance therapy in first plateau phase of multiple myeloma. MRC working party on leukemia in adults
    • Drayson MT, Chapman CE, Dunn JA, et al. MRC trial of alpha-2b-interferon maintenance therapy in first plateau phase of multiple myeloma. MRC working party on leukemia in adults. Br J Hematol. 1998;101:195-202.
    • (1998) Br J Hematol , vol.101 , pp. 195-202
    • Drayson, M.T.1    Chapman, C.E.2    Dunn, J.A.3
  • 18
    • 35348923502 scopus 로고    scopus 로고
    • Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: A report from the GIMEMA Italian Multiple Myeloma Network
    • Palumbo A, Falco P, Corradini P, et al. Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA Italian Multiple Myeloma Network. J Clin Oncol. 2007;25:4459-4465.
    • (2007) J Clin Oncol , vol.25 , pp. 4459-4465
    • Palumbo, A.1    Falco, P.2    Corradini, P.3
  • 19
    • 69249189562 scopus 로고    scopus 로고
    • Bortezomib-doxorubicin-dexamethasone as induction prior to reduced intensity autologous transplantation followed by lenalidomide as consolidation/maintenance in elderly untreated myeloma patients
    • Palumbo A, Falco P, Gay F, et al. Bortezomib-doxorubicin-dexamethasone as induction prior to reduced intensity autologous transplantation followed by lenalidomide as consolidation/maintenance in elderly untreated myeloma patients. Blood. 2008;112:159.
    • (2008) Blood , vol.112 , pp. 159
    • Palumbo, A.1    Falco, P.2    Gay, F.3
  • 21
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus Dexamethasone for relapsed multiple myeloma in North America
    • Weber D, Chen C, Niesvizky R, et al. Lenalidomide plus Dexamethasone for relapsed multiple myeloma in North America. N Engl J Med. 2007;357:2133-2142.
    • (2007) N Engl J Med , vol.357 , pp. 2133-2142
    • Weber, D.1    Chen, C.2    Niesvizky, R.3
  • 22
    • 36349023319 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed ore refractory multiple myeloma
    • Dimopoulos M, Spencer A, Attal M, et al. Lenalidomide plus dexamethasone for relapsed ore refractory multiple myeloma. N Engl J Med. 2007;357:2123-2132.
    • (2007) N Engl J Med , vol.357 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 23
    • 71949120490 scopus 로고    scopus 로고
    • Longer duration of treatment and maintenance of best response with lenalidomide and dexamethasone prolongs overall survival in patients with relapsed or refractory multiple myeloma
    • San Miguel JF, Dimopoulos MA, Stadtmauer EA, et al. Longer duration of treatment and maintenance of best response with lenalidomide and dexamethasone prolongs overall survival in patients with relapsed or refractory multiple myeloma. Blood. 2008;112:3702.
    • (2008) Blood , vol.112 , pp. 3702
    • San Miguel, J.F.1    Dimopoulos, M.A.2    Stadtmauer, E.A.3
  • 24
    • 35148825003 scopus 로고    scopus 로고
    • Extended follow-up of a phase 3 trial in relapsed multiple myeloma: Final time-to-event results of the APEX trial
    • Richardson PG, Sonneveld P, Schuster M, et al. Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial. Blood. 2007;110:3557-3560.
    • (2007) Blood , vol.110 , pp. 3557-3560
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.3
  • 25
    • 71949104696 scopus 로고    scopus 로고
    • Combination of lenalidomide, melphalan, prednisone and thalidomide (RMPT) in relapsed/refractory multiple myeloma: Results of a Multi center Phase II clinical trial
    • Palumbo A, Falco P, Sanpaolo G, et al. Combination of lenalidomide, melphalan, prednisone and thalidomide (RMPT) in relapsed/refractory multiple myeloma: results of a Multicenter Phase II clinical trial. Blood. 2008; 112:868.
    • (2008) Blood , vol.112 , pp. 868
    • Palumbo, A.1    Falco, P.2    Sanpaolo, G.3
  • 26
    • 75149125329 scopus 로고    scopus 로고
    • Phase I/II trial of bortezomib maintenance in order to prolong remission duration following autologous peripheral blood progenitor cell transplantation as treatment for intermediate and advanced stage multiple myeloma
    • Schiller GJ, Liao M, Sohn JP, et al. Phase I/II trial of bortezomib maintenance in order to prolong remission duration following autologous peripheral blood progenitor cell transplantation as treatment for intermediate and advancedstage multiple myeloma. Blood. 2007;110:3617.
    • (2007) Blood , vol.110 , pp. 3617
    • Schiller, G.J.1    Liao, M.2    Sohn, J.P.3
  • 27
    • 67349269915 scopus 로고    scopus 로고
    • Bortezomib administered pre-auto-SCT and as maintenance therapy post-transplant for multiple myeloma: A single institution phase II study
    • Uy GL, Goyal SD, Fisher NM, et al. Bortezomib administered pre-auto-SCT and as maintenance therapy post-transplant for multiple myeloma: a single institution phase II study. Bone Marrow Transpl. 2009;43:793-800.
    • (2009) Bone Marrow Transpl , vol.43 , pp. 793-800
    • Uy, G.L.1    Goyal, S.D.2    Fisher, N.M.3
  • 28
    • 64749108582 scopus 로고    scopus 로고
    • First analysis of HOVON-65/GMMG-HD4 randomized phase III trial comparing bortezomib, adriamycine, dexamethasone (PAD) vs VAD as induction treatment prior to high dose melphalan (HDM) in patients with newly diagnosed multiple myeloma (MM)
    • Sonneveld P, van der Holt B, Schimdt-Wolf GH, et al. First analysis of HOVON-65/GMMG-HD4 randomized phase III trial comparing bortezomib, adriamycine, dexamethasone (PAD) vs VAD as induction treatment prior to high dose melphalan (HDM) in patients with newly diagnosed multiple myeloma (MM). Blood. 2008;112:653.
    • (2008) Blood , vol.112 , pp. 653
    • Sonneveld, P.1    Van Der Holt, B.2    Schimdt-Wolf, G.H.3
  • 29
    • 75149164514 scopus 로고    scopus 로고
    • Primari therapy with bortezomibthe role of induction, maintenance and re-induction in patients with high-risk myeloma. Update of results from E2A02
    • Dispenzieri A, Jacobus S, Vesole D, et al. Primari therapy with bortezomibthe role of induction, maintenance and re-induction in patients with high-risk myeloma. Update of results from E2A02. Blood. 2008;112:1738.
    • (2008) Blood , vol.112 , pp. 1738
    • Dispenzieri, A.1    Jacobus, S.2    Vesole, D.3
  • 30
    • 70350700998 scopus 로고    scopus 로고
    • A prospective, randomized, phase iii study of bortezomib, melphalan, prednisone and thalidomide (VMPT) versus bortezomib, melphalan and prednisone (VMP) in elderly newly diagnosed myeloma patients
    • Palumbo A, Bringhen S, Rossi D, et al. A prospective, randomized, phase iii study of bortezomib, melphalan, prednisone and thalidomide (VMPT) versus bortezomib, melphalan and prednisone (VMP) in elderly newly diagnosed myeloma patients. Blood. 2008;112:652.
    • (2008) Blood , vol.112 , pp. 652
    • Palumbo, A.1    Bringhen, S.2    Rossi, D.3
  • 31
    • 70450268548 scopus 로고    scopus 로고
    • Bortezomib and dexamethasone as maintenance therapy in relapsed/refractory multiple myeloma patients
    • abstract 2771
    • Benevolo G, LaroccaA, Pregno P, et al. Bortezomib and dexamethasone as maintenance therapy in relapsed/refractory multiple myeloma patients. Blood. 2008;112:abstract 2771.
    • (2008) Blood , vol.112
    • Benevolo, G.1    Laroccaa Pregno, P.2
  • 32
    • 75149186681 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib and dexamethasone in relapsed/refractory multiple myeloma (MM): Encouraging outcomes and tolerability in phase II study
    • (abstract 8536)
    • Anderson KC, Jagannath S, Jakubowiak A, et al. Lenalidomide, bortezomib and dexamethasone in relapsed/refractory multiple myeloma (MM): encouraging outcomes and tolerability in phase II study. J Clin Oncol. 2009;27:15s (abstract 8536).
    • (2009) J Clin Oncol , vol.27
    • Anderson, K.C.1    Jagannath, S.2    Jakubowiak, A.3


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