Effect of water-soluble polymers on the physical stability of aqueous polymeric dispersions and their implications on the drug release from coated pellets

Drug Development and Industrial Pharmacy

Volumn 36, Issue 2, 2010, Pages 152-160

  Dashevsky, Andrei ^a   Ahmed, Abid Riaz ^a   Mota, J ^a   Irfan, Muhammad ^a   Kolter, Karl ^b   Bodmeier, Roland A ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b BASF SE   (Germany)

Author keywords

Aqueous polymer dispersion; Coating; Extended drug release; Flocculation; Turbidimetric measurements

Indexed keywords

ETHYL CELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; POLYMER; POLYVINYL ACETATE; POLYVINYL ALCOHOL; POVIDONE; PROPRANOLOL; THEOPHYLLINE; WATER;

ARTICLE; DISPERSION; DRUG COATING; DRUG PELLET; DRUG RELEASE; DRUG STABILITY; FLOCCULATION; FLUIDIZED BED; TURBIDIMETRY;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG IMPLANTS; DRUG STABILITY; EXCIPIENTS; FLOCCULATION; KINETICS; NEPHELOMETRY AND TURBIDIMETRY; POLYVINYLS; PROPRANOLOL; SOLUBILITY; THEOPHYLLINE;

EID: 75149123559     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639040903410334     Document Type: Article

References (14)

1. Cole G, Hogan G, Aulton ME. (1995). Pharmaceutical coating technology. London: Taylor & Francis.
2. McGinity JW, Felton LA. (2008). Aqueous polymeric coatings for pharmaceutical dosage forms. 3rd ed. New York: Informa Healthcare.
3. Wesseling M, Bodmeier R. (1999). Drug release from beads coated with an aqueous colloidal ethylcellulose dispersion, aquacoat, or an organic ethylcellulose solution. Eur J Pharm Biopharm, 47:33-38
4. Frohoff-Hülsmann MA, Schmitz A, Lippold BC. (1999). Aqueous ethylcellulose dispersion containing plasticizers of different water solubility and hydroxypropyl methyl-cellulose as coating material for diffusion pellets: I. Drug release rates from coated pellets. Int J Pharm, 177:69-82.
5. Lippold BC, Pagés RM. (2001). Control and stability of drug release from diffusion pellets coated with the aqueous quaternary polymethacrylate dispersion Eudragit® RS 30D. Pharmazie, 56:477-483
6. Zheng W, Sauer D, McGinity JW. (2005). Influence of hydroxyethylcellulose on the drug release properties of theophylline pellets coated with Eudragit® RS 30 D. Eur J Pharm Biopharm, 59:147-154
7. Dashevsky A, Wagner K, Kolter K, Bodmeier R. (2005). Physicochemical and release properties of pellets coated with Kollicoat SR 30 D, a new aqueous polyvinyl acetate dispersion for extended release. Int J Pharm, 290:15-23.
8. Dashevsky A, Kolter K, Bodmeier R. (2004). Water soluble poreformers for the controlled release aqueous dispersions Kollicoat ® SR 30 D and Aquacoat® ECD. 2004 AAPS Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, Baltimore, MD, Vol.6, Abstract T3200.
9. Siepmann F, Hoffmann A, Leclercq B, Carlinc B, Siepmann J. (2007). How to adjust desired drug release patterns from ethylcellulose-coated dosage forms. J Control Release, 119(2):182-189
10. Siepmann F, Muschert S, Leclercq B, Carlin B, Siepmann J. (2008). How to improve the storage stability of aqueous polymeric film coatings. J Control Release, 126(1):26-33.
11. Wong D, Bodmeier R. (1996). Flocculation of an aqueous colloidal ethyl cellulose dispersion (Aquacoat® ) with a water-soluble polymer, hydroxypropyl methylcellulose. Eur J Pharm Biopharm, 42:12-15
12. Wong D. (1994). Water-soluble polymers in pharmaceutical aqueous colloidal polymer dispersions. Ph.D. thesis, University of Texas at Austin, Austin, USA.
13. Mengual O, Meunier G, Cayre I, Puech K, Snabre P. (1999). Turbiscan MA 2000: Multiple light scattering measurement for concentrated emulsion and suspension instability analysis. Talanta, 50:445-456
14. Wagner K. (2002). Aqueous polymer dispersions for extended release dosage forms. PhD thesis, Freie Universität Berlin, Germany.