CD4+ and CD8+ T cells mediated direct cytotoxic effect against Trichophyton rubrum and Trichophyton mentagrophytes

International Journal of Dermatology

Volumn 49, Issue 2, 2010, Pages 149-157

  Waldman, Arie ^a   Segal, Rina ^b   Berdicevsky, Israela ^a   Gilhar, Amos ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ADULT; ARTHRODERMA GYPSEUM; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MEDIATED CYTOTOXICITY; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOMYCOSIS; FEMALE; FUNGUS CULTURE; FUNGUS HYPHAE; FUNGUS IMMUNITY; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; TRICHOPHYTON MENTAGROPHYTES; TRICHOPHYTON RUBRUM;

ADULT; ARTHRODERMATACEAE; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; CHRONIC DISEASE; DERMATOMYCOSES; FEMALE; HLA-DR ANTIGENS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES, MONONUCLEAR; MALE; MICROSCOPY, ELECTRON, SCANNING TRANSMISSION; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; PROBABILITY; TRICHOPHYTON; YOUNG ADULT;

EID: 74949140731     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2009.04222.x     Document Type: Article

References (44)

1. Hay RJ. Chronic dermatophyte infections: clinical and mycological features. Br J Dermatol 1982, 106:1-7.
2. Schmid-Wendtner M-H, Korting HC. Effective treatment for dermatophytosis of the foot: effect on restoration of depressed cell-mediated immunity. J Eur Acad Dermatol Venereol 2007, 21:1013-1018.
3. Ryder NS, Favre B. Antifungal activity and mechanism of action of terbinafine. Rev Contemp Pharmacother 1997, 8:275-288.
4. Burzykowski T, Molenberghs G, Abeck D. High prevalence of foot diseases in Europe: results of the Achilles Project. Mycoses 2003, 46:496-505.
5. Pierard G. Onychomycosis and other superficial fungal infections of the foot in the elderly: a pan-European survey. Dermatology 2001, 202:220-224.
6. Whittam LR, Hay RJ. The impact of onychomycosis on quality of life. Clin Exp Dermatol 1997, 22:87-89.
7. Katsambas A, Abeck D, Haneke E. The effects of foot disease on quality of life: results of the Achilles Project. J Eur Acad Dermatol Venereol 2005, 19:191-195.
8. Roujeau JC, Sigurgeirsson B, Korting HC. Chronic dermatomycoses of the foot as risk factors for acute bacterial cellulitis of the leg: a case-control study. Dermatology 2004, 209:301-307.
9. Jones HE. Immune response and host resistance of humans to dermatophyte infection. J Am Acad Dermatol 1993, 28:S12-S18.
10. Szepes E, Magyarlaki M, Battyani Z, Schneider I. Immunohistological characterization of the cellular infiltrate in dermatophytosis. Mycoses 1993, 36:203-206.
11. Gupta AK, Taborda P, Taborda V. Epidemiology and prevalence of onychomycosis in HIV-positive individuals. Int J Dermatol 2000, 39:746-753.
12. Green F, Weber JK, Balish E. The thymus dependency of acquired resistance to Trichophyton mentagrophytes dermatophytosis in rats. J Invest Dermatol 1983, 81:31-38.
13. Calderon RA, Hay RJ. Cell-mediated immunity in experimental murine dermatophytosis: adoptive transfer of immunity to dermatophyte infection by lymphoid cells from donors with acute or chronic infections. Immunology 1984, 53:465-472.
14. Allen DE, Snyderman R, Meadows L, Pinnell SR. Generalized Microsporum audoninii infection and depressed cellular immunity associated with a missing plasma factor required for lymphocyte blastogenesis. Am J Med 1977, 63:991-1000.
15. Jones HE, Reinhardt JH, Rinaldi MG. Immunologic susceptibility to chronic dermatophytosis. Arch Dermatol 1974, 110:213-220.
16. Jones HE, Reinhardt JH, Rinaldi MG. Model dermatophytosis in naturally infected subjects. Arch Dermatol 1974, 110:369-374.
17. Zheng CF, Ma LL, Jones GJ. Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients. Blood 2007, 109:2049-2057.
18. Abdel-Rahman SM. Strain differentiation of dermatophytes. Mycopathologia 2008, 166:319-333.
19. Airaudi D, Ceruti M, Giannetta A, Filipello Marchisio V. Preliminary screening of some squalenoid derivatives for toxicity towards dermatophytes. Mycoses 1995, 38:311-315.
20. Gilhar A, Landau M, Assy B. Mediation of alopecia areata by cooperation between CD4+ and CD8+ T lymphocytes: transfer to human scalp explants on Prkdc(scid) mice. Arch Dermatol 2002, 138:916-922.
21. Gilhar A, Ullmann Y, Berkutzki T. Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 1998, 101:62-67.
22. Gerlier D, Thomasset N. Use of MTT colorimetric assay to measure cell activation. J Immunol Methods 1986, 94:57-63.
23. Roehm NW, Rodgers GH, Hatfield SM, Glasebrook AL. An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT. J Immunol Methods 1991, 142:257-265.
24. Jost LM, Kirkwood JM, Whiteside TL. Improved short- and long-term XTT- based colorimetric cellular cytotoxicity assay for melanoma and other tumor cells. J Immunol Methods 1992, 147:153-165.
25. Duek L, Kaufman G, Ulman Y, Berdicevsky I. The pathogenesis of dermatophyte infections in human skin sections. J Infect 2004, 48:175-180.
26. van den Broeke LT, Daschbach E, Thomas EK. Dendritic cell-induced activation of adaptive and innate antitumor immunity. J Immunol 2003, 171:5842-5852.
27. Weitzman I, Summerbell RC. The dermatophytes. Clin Microbiol Rev 1995, 8:240-259.
28. Calderon RA. Immunoregulation of dermatophytosis. Crit Rev Microbiol 1989, 16:338-368.
29. Hay RJ, Calderon RA, Collins MJ. Experimental dermatophytosis: the clinical and histopathologic features of a mouse model using Trichophyton quinckeanum (mouse favus). J Invest Dermatol 1983, 81:270-274.
30. Heikkila H, Stubb S. Long-term results in patients with onychomycosis treated with terbinafine or itraconazole. Br J Dermatol 2002, 461:250-253.
31. Schneider DS, Ayres JS. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol 2008, 8:889-895.
32. Hahn S, Gehri R, Erb P. Mechanism and biological significance of CD4-mediated cytotoxicity. Immunol Rev 1995, 146:57-79.
33. Faber LM, van Luxemburg-Heijs SA, Veenhof WF. Generation of CD4+ cytotoxic T-lymphocyte clones from a patient with severe graft-versus-host disease after allogeneic bone marrow transplantation: implications for graft-versus-leukemia reactivity. Blood 1995, 86:2821-2828.
34. Paludan C, Bickham K, Nikiforow S. Epstein-Barr nuclear antigen 1- specific CD4 (+) Th1 cells kill Burkitt's lymphoma cells. J Immunol 2002, 169:1593-1603.
35. Ma LL, Mody CH. Granulysin and direct lymphocyte-mediated antimicrobial and antitumor activity. Mod Asp Immunobiol 2005, 16:18-20.
36. Duncan RA, von Reyn CF, Alliegro GM. Idiopathic CD4+ T- lymphocytopenia-four patients with opportunistic infections and no evidence of HIV infection. N Engl J Med 1993, 328:393-398.
37. Murphy JW, Hidore MR, Wong SC. Direct interactions of human lymphocytes with the yeast-like organism, Cryptococcus neoformans. J Clin Invest 1993, 91:1553-1566.
38. Levitz SM, Dupont MP, Smail EH. Direct activity of human T lymphocytes and natural killer cells against Cryptococcus neoformans. Infect Immun 1994, 62:194-202.
39. Mody CH, Lipscomb MF, Street NE, Toews GB. Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans. J Immunol 1990, 144:1472-1477.
40. Shoham S, Levitz SM. The immune response to fungal infections. Br J Hematol 2005, 129:569-582.
41. Huffnagle GB, Lipscomb MF, Lovchik JA. The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J Leukoc Biol 1994, 55:35-42.
42. Dahl MV. Suppression of immunity and inflammation by products produced by dermatophytes. J Am Acad Dermatol 1993, 28:S19-S23.
43. Blake JS, Dahl MV, Herron MJ, Nelson RD. An immunoinhibitory cell wall glycoprotein (mannan) from Trichophyton rubrum. J Invest Dermatol 1991, 96:657-661.
44. MacCarthy KG, Blake JS, Johnson KL. Human dermatophyte-responsive T- cell lines recognize cross-reactive antigens associated with mannose-rich glycoproteins. Exp Dermatol 1994, 3:66-71.