메뉴 건너뛰기




Volumn 51, Issue 1, 2010, Pages 27-38

Thalidomide and lenalidomide as new therapeutics for the treatment of chronic lymphocytic leukemia

Author keywords

Chronic lymphocytic leukemia; Lenalidomide; Thalidomide; Tumor flare reaction; Tumor lysis syndrome

Indexed keywords

FLUDARABINE; LENALIDOMIDE; OBLIMERSEN; RITUXIMAB; THALIDOMIDE;

EID: 74949135128     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428190903350405     Document Type: Review
Times cited : (31)

References (66)
  • 1
    • 33947541773 scopus 로고    scopus 로고
    • Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997
    • Flinn IW, Neuberg DS, Grever MR, et al. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol 2007; 25:793-798.
    • (2007) J Clin Oncol , vol.25 , pp. 793-798
    • Flinn, I.W.1    Neuberg, D.S.2    Grever, M.R.3
  • 2
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
    • Catovsky D, Richards S, Matutes E, et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet 2007;370:230-239.
    • (2007) Lancet , vol.370 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Matutes, E.3
  • 3
    • 31544434508 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
    • Eichhorst BF, Busch R, Hopfinger G, et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood 2006;107:885-891.
    • (2006) Blood , vol.107 , pp. 885-891
    • Eichhorst, B.F.1    Busch, R.2    Hopfinger, G.3
  • 5
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai K, Peterson BL, et al. Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 2005; 105:49-53.
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3
  • 6
    • 61849091076 scopus 로고    scopus 로고
    • Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression-free survival (PFS) of previously untreated patients (pts) with advanced chronic lymphocytic leukemia (CLL)
    • Abstract
    • Hallek M, Fingerle-Rowson G, Fink A-M, et al. Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression-free survival (PFS) of previously untreated patients (pts) with advanced chronic lymphocytic leukemia (CLL). Blood 2008; 112(Suppl.):325 (Abstract).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 325
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.-M.3
  • 7
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood 2002;99:3554-3561.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 8
    • 27144548424 scopus 로고    scopus 로고
    • Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase I/II study of the German CLL Study Group
    • Bergmann MA, Goebeler ME, Herold M, et al. Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase I/II study of the German CLL Study Group. Haematologica 2005;90:1357-1364.
    • (2005) Haematologica , vol.90 , pp. 1357-1364
    • Bergmann, M.A.1    Goebeler, M.E.2    Herold, M.3
  • 9
    • 0346258157 scopus 로고    scopus 로고
    • High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities
    • Thornton PD, Matutes E, Bosanquet AG, et al. High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities. Ann Hematol 2003;82:759-765.
    • (2003) Ann Hematol , vol.82 , pp. 759-765
    • Thornton, P.D.1    Matutes, E.2    Bosanquet, A.G.3
  • 10
    • 33846219417 scopus 로고    scopus 로고
    • Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
    • Byrd JC, Lin TS, Dalton JT, et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 2007;109:399-404.
    • (2007) Blood , vol.109 , pp. 399-404
    • Byrd, J.C.1    Lin, T.S.2    Dalton, J.T.3
  • 11
    • 38949185742 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study
    • Coiffier B, Lepretre S, Pedersen LM, et al. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study. Blood 2008;111: 1094-1100.
    • (2008) Blood , vol.111 , pp. 1094-1100
    • Coiffier, B.1    Lepretre, S.2    Pedersen, L.M.3
  • 12
    • 38349163290 scopus 로고    scopus 로고
    • Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine- refractory chronic lymphocytic leukemia
    • Tsimberidou AM, Wierda WG, Plunkett W, et al. Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol 2008;26:196-203.
    • (2008) J Clin Oncol , vol.26 , pp. 196-203
    • Tsimberidou, A.M.1    Wierda, W.G.2    Plunkett, W.3
  • 13
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood 2004;103:3278-3281.
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3
  • 14
    • 27144437196 scopus 로고    scopus 로고
    • The efficacy of alemtuzumab for refractory chronic lymphocytic leukemia in relation to cytogenetic abnormalities of p53
    • Osuji NC, Del Giudice I, Matutes E, Wotherspoon AC, Dearden C, Catovsky D. The efficacy of alemtuzumab for refractory chronic lymphocytic leukemia in relation to cytogenetic abnormalities of p53. Haematologica 2005;90: 1435-1436.
    • (2005) Haematologica , vol.90 , pp. 1435-1436
    • Osuji, N.C.1    Del Giudice, I.2    Matutes, E.3    Wotherspoon, A.C.4    Dearden, C.5    Catovsky, D.6
  • 16
    • 37149029392 scopus 로고    scopus 로고
    • Methylprednisolonerituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features
    • Bowen DA, Call TG, Jenkins GD, et al. Methylprednisolonerituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features. Leuk Lymphoma 2007;48: 2412-2417.
    • (2007) Leuk Lymphoma , vol.48 , pp. 2412-2417
    • Bowen, D.A.1    Call, T.G.2    Jenkins, G.D.3
  • 17
    • 56249095457 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia
    • Castro JE, Sandoval-Sus JD, Bole J, Rassenti L, Kipps TJ. Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia. Leukemia 2008;22:2048-2053.
    • (2008) Leukemia , vol.22 , pp. 2048-2053
    • Castro, J.E.1    Sandoval-Sus, J.D.2    Bole, J.3    Rassenti, L.4    Kipps, T.J.5
  • 18
    • 54449093967 scopus 로고    scopus 로고
    • Five-year followup of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
    • Sorror ML, Storer BE, Sandmaier BM, et al. Five-year followup of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol 2008;26:4912-4920.
    • (2008) J Clin Oncol , vol.26 , pp. 4912-4920
    • Sorror, M.L.1    Storer, B.E.2    Sandmaier, B.M.3
  • 19
    • 28844483804 scopus 로고    scopus 로고
    • Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia
    • Gribben JG, Zahrieh D, Stephans K, et al. Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia. Blood 2005;106:4389-4396.
    • (2005) Blood , vol.106 , pp. 4389-4396
    • Gribben, J.G.1    Zahrieh, D.2    Stephans, K.3
  • 21
    • 0034141541 scopus 로고    scopus 로고
    • Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells
    • Decker T, Schneller F, Sparwasser T, et al. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 2000;95:999-1006.
    • (2000) Blood , vol.95 , pp. 999-1006
    • Decker, T.1    Schneller, F.2    Sparwasser, T.3
  • 22
    • 33646485424 scopus 로고    scopus 로고
    • Thymidinephosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference
    • Castro JE, Prada CE, Aguillon RA, et al. Thymidinephosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference. Leukemia 2006;20:680-688.
    • (2006) Leukemia , vol.20 , pp. 680-688
    • Castro, J.E.1    Prada, C.E.2    Aguillon, R.A.3
  • 23
    • 24944518705 scopus 로고    scopus 로고
    • Thalidomide (Td) treatment in chronic lymphocytic leukemia (CLL): A North Central Cancer Treatment Group (NCCTG) study
    • Abstract
    • Kay NE, Geyer S, Yaqoob I. Thalidomide (Td) treatment in chronic lymphocytic leukemia (CLL): a North Central Cancer Treatment Group (NCCTG) study. Blood 2003; 102(Suppl.):5162a (Abstract).
    • (2003) Blood , vol.102 , Issue.SUPPL.
    • Kay, N.E.1    Geyer, S.2    Yaqoob, I.3
  • 24
    • 37049018464 scopus 로고    scopus 로고
    • Phase II study of thalidomide in escalating doses for follicular (F-NHL) and small lymphocytic lymphoma (Sll): CALGB Study 50002
    • Abstract
    • Grinblatt DL, Johnson J, Niedzwicki D, Rizzieri DA, Bartlett N, Cheson BD. Phase II study of thalidomide in escalating doses for follicular (F-NHL) and small lymphocytic lymphoma (Sll): CALGB Study 50002. Blood 2004;104(Suppl.): 3284 (Abstract).
    • (2004) Blood , vol.104 , Issue.SUPPL. , pp. 3284
    • Grinblatt, D.L.1    Johnson, J.2    Niedzwicki, D.3    Rizzieri, D.A.4    Bartlett, N.5    Cheson, B.D.6
  • 25
    • 68449101813 scopus 로고    scopus 로고
    • N9986: A phase II trial of thalidomide in patients with relapsed chronic lymphocytic leukemia
    • Kay NE, Shanafelt TD, Call TG, Wu W, Laplant BR. N9986: a phase II trial of thalidomide in patients with relapsed chronic lymphocytic leukemia. Leuk Lymphoma 2009;50: 588-592.
    • (2009) Leuk Lymphoma , vol.50 , pp. 588-592
    • Kay, N.E.1    Shanafelt, T.D.2    Call, T.G.3    Wu, W.4    Laplant, B.R.5
  • 26
    • 12744281454 scopus 로고    scopus 로고
    • NCI CETP. 3rd ed. NIH; accessed June 30, 2009
    • NCI, CETP. Common terminology criteria for adverse events (CTCAE). 3rd ed. NIH; 2006. p 70. http://ctep.cancer.gov/ protocoldevelopment/electronic- applications/docs/ctcaev3notice. pdf, accessed June 30, 2009.
    • (2006) Common Terminology Criteria for Adverse Events (CTCAE) , pp. 70
  • 27
    • 33645964853 scopus 로고    scopus 로고
    • Thalidomide alone or in combination with fludarbabine are effective treatments for patients with fludarabine-relapsed and refractory CLL
    • Abstract
    • Furman RR, Leonard JP, Allen SL, Coleman M, Rosenthal T, Gabrilove JL. Thalidomide alone or in combination with fludarbabine are effective treatments for patients with fludarabine-relapsed and refractory CLL. J Clin Oncol 2005; 23(Suppl.):6640 (Abstract).
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL. , pp. 6640
    • Furman, R.R.1    Leonard, J.P.2    Allen, S.L.3    Coleman, M.4    Rosenthal, T.5    Gabrilove, J.L.6
  • 28
    • 33845217424 scopus 로고    scopus 로고
    • Low-dose thalidomide in combination with oral fludarabine and cyclophosphamide is ineffective in heavily pre-treated patients with chronic lymphocytic leukemia
    • Laurenti L, Piccioni P, Tarnani M, et al. Low-dose thalidomide in combination with oral fludarabine and cyclophosphamide is ineffective in heavily pre-treated patients with chronic lymphocytic leukemia. Leuk Res 2007;31:253-256.
    • (2007) Leuk Res , vol.31 , pp. 253-256
    • Laurenti, L.1    Piccioni, P.2    Tarnani, M.3
  • 29
    • 27744597929 scopus 로고    scopus 로고
    • Results of a phase 1 clinical trial of thalidomide in combination with fludarabine as initial therapy for patients with treatmentrequiring chronic lymphocytic leukemia (CLL)
    • Chanan-Khan A, Miller KC, Takeshita K, et al. Results of a phase 1 clinical trial of thalidomide in combination with fludarabine as initial therapy for patients with treatmentrequiring chronic lymphocytic leukemia (CLL). Blood 2005; 106:3348-3352.
    • (2005) Blood , vol.106 , pp. 3348-3352
    • Chanan-Khan, A.1    Miller, K.C.2    Takeshita, K.3
  • 30
    • 70350123882 scopus 로고    scopus 로고
    • Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia
    • Giannopoulos K, Dmoszynska A, Kowal M, et al. Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia. Leukemia 2009;23:1771-1778.
    • (2009) Leukemia , vol.23 , pp. 1771-1778
    • Giannopoulos, K.1    Dmoszynska, A.2    Kowal, M.3
  • 31
    • 54149088114 scopus 로고    scopus 로고
    • Thalidomide alone and in combination with fludarabine exerts distinct molecular and antileukemic effects in B-cell chronic lymphocytic leukemia
    • Abstract
    • Giannopoulos K, Dmoszynska A, Kowal M, et al. Thalidomide alone and in combination with fludarabine exerts distinct molecular and antileukemic effects in B-cell chronic lymphocytic leukemia. Blood 2007;110(Suppl.):3124 (Abstract).
    • (2007) Blood , vol.110 , Issue.SUPPL. , pp. 3124
    • Giannopoulos, K.1    Dmoszynska, A.2    Kowal, M.3
  • 32
    • 74949113347 scopus 로고    scopus 로고
    • Thalidomide is active alone and in combination with fludarabine in fludarabine-relapsed and refractory chronic lymphocytic leukemia
    • Abstract
    • Furman RR, Allen SL, Leonard JP, Coleman M, Markis JM, Gabrilove JL. Thalidomide is active alone and in combination with fludarabine in fludarabine-relapsed and refractory chronic lymphocytic leukemia. Blood 2004;104(Suppl.):4835 (Abstract).
    • (2004) Blood , vol.104 , Issue.SUPPL. , pp. 4835
    • Furman, R.R.1    Allen, S.L.2    Leonard, J.P.3    Coleman, M.4    Markis, J.M.5    Gabrilove, J.L.6
  • 33
    • 33947243663 scopus 로고    scopus 로고
    • Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study
    • Chanan-Khan A, Miller KC, Musial L, et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol 2006;24:5343-5349.
    • (2006) J Clin Oncol , vol.24 , pp. 5343-5349
    • Chanan-Khan, A.1    Miller, K.C.2    Musial, L.3
  • 34
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli A, Lee BN, Schlette EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2008;111: 5291-5297.
    • (2008) Blood , vol.111 , pp. 5291-5297
    • Ferrajoli, A.1    Lee, B.N.2    Schlette, E.J.3
  • 35
    • 71649085254 scopus 로고    scopus 로고
    • Preliminary results of a phase 1/2, multi-center, open-label study (CLL-001) investigating a stepwise dose-escalation schedule of lenalidomide in relapsed or refractory chronic lymphocytic leukemia
    • Abstract
    • Wendtner CM, Mahadevan D, Stilgenbauer S, et al. Preliminary results of a phase 1/2, multi-center, open-label study (CLL-001) investigating a stepwise dose-escalation schedule of lenalidomide in relapsed or refractory chronic lymphocytic leukemia. Blood 2008;112(Suppl.):2104 (Abstract).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 2104
    • Wendtner, C.M.1    Mahadevan, D.2    Stilgenbauer, S.3
  • 36
    • 34147181695 scopus 로고    scopus 로고
    • Early results from a phase II study of lenalidomide monotherapy in relapsed/ refractory indolent non-Hodgkin's lymphoma
    • Abstract
    • Witzig TE, Vose JM, Kaplan HP, et al. Early results from a phase II study of lenalidomide monotherapy in relapsed/ refractory indolent non-Hodgkin's lymphoma. Blood 2006; 108(Suppl.):2482 (Abstract).
    • (2006) Blood , vol.108 , Issue.SUPPL. , pp. 2482
    • Witzig, T.E.1    Vose, J.M.2    Kaplan, H.P.3
  • 37
    • 67649395340 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy in relapsed/refractory small lymphocytic non-Hodgkin's lymphoma
    • abstr 8573
    • Witzig TE, Vose JM, Justice G, et al. Lenalidomide oral monotherapy in relapsed/refractory small lymphocytic non-Hodgkin's lymphoma. J Clin Oncol 2008;26:abstr 8573.
    • (2008) J Clin Oncol , vol.26
    • Witzig, T.E.1    Vose, J.M.2    Justice, G.3
  • 38
    • 45149115902 scopus 로고    scopus 로고
    • Higher doses of lenalidomide are associated with unacceptable toxicity including life threatening tumor flare in patients with chronic lymphocytic leukemia
    • Andritsos L, Johnson AJ, Lozanski G, et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 2008;26:2519-2525.
    • (2008) J Clin Oncol , vol.26 , pp. 2519-2525
    • Andritsos, L.1    Johnson, A.J.2    Lozanski, G.3
  • 39
    • 36849068944 scopus 로고    scopus 로고
    • Tumor lysis syndrome/tumor flare reaction in lenalidomide-treated chronic lymphocytic leukemia
    • Moutouh-de Parseval LA, Weiss L, DeLap RJ, Knight RD, Zeldis JB. Tumor lysis syndrome/tumor flare reaction in lenalidomide-treated chronic lymphocytic leukemia. J Clin Oncol 2007;25:5047.
    • (2007) J Clin Oncol , vol.25 , pp. 5047
    • Moutouh-De Parseval, L.A.1    Weiss, L.2    Delap, R.J.3    Knight, R.D.4    Zeldis, J.B.5
  • 40
    • 66749113746 scopus 로고    scopus 로고
    • A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL)
    • Astract
    • Chen C, Paul H, Xu W, et al. A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL). Blood 2008;112(Suppl.):44 (Abstract).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 44
    • Chen, C.1    Paul, H.2    Xu, W.3
  • 41
    • 69049084353 scopus 로고    scopus 로고
    • Lenalidomide as initial treatment of elderly patients with chronic lymphocytic leukemia (CLL)
    • Astract
    • Ferrajoli A, O'Brien S, Wierda W, et al. Lenalidomide as initial treatment of elderly patients with chronic lymphocytic leukemia (CLL). Blood 2008;112(Suppl.):45 (Abstract).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 45
    • Ferrajoli, A.1    O'Brien, S.2    Wierda, W.3
  • 42
    • 73849140334 scopus 로고    scopus 로고
    • Lenalidomide induced cytokine release syndrome in chronic lymphocytic leukemia (CLL): Clinical and laboratory correlates of immune activation
    • Abstract
    • Aue G, Njuguna N, Tian X, et al. Lenalidomide induced cytokine release syndrome in chronic lymphocytic leukemia (CLL): clinical and laboratory correlates of immune activation. Blood 2008;112(Suppl.):2099 (Abstract).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 2099
    • Aue, G.1    Njuguna, N.2    Tian, X.3
  • 43
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli A, Lee BN, Schlette EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2008;111:5291-5297.
    • (2008) Blood , vol.111 , pp. 5291-5297
    • Ferrajoli, A.1    Lee, B.N.2    Schlette, E.J.3
  • 44
    • 0033168605 scopus 로고    scopus 로고
    • Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-{a}
    • Corral LG, Haslett PAJ, Muller GW, et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-{a}. J Immunol 1999;163:380-386.
    • (1999) J Immunol , vol.163 , pp. 380-386
    • Corral, L.G.1    Haslett, P.A.J.2    Muller, G.W.3
  • 45
    • 0036855805 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory drugs as cancer therapy
    • Raje N, Anderson KC. Thalidomide and immunomodulatory drugs as cancer therapy. Curr Opin Oncol 2002;14:635-640.
    • (2002) Curr Opin Oncol , vol.14 , pp. 635-640
    • Raje, N.1    Anderson, K.C.2
  • 46
    • 4344641976 scopus 로고    scopus 로고
    • Immunomodulatory analogs of thalidomide: An emerging new therapy in myeloma
    • Richardson P, Anderson K. Immunomodulatory analogs of thalidomide: an emerging new therapy in myeloma. J Clin Oncol 2004;22:3212-3214.
    • (2004) J Clin Oncol , vol.22 , pp. 3212-3214
    • Richardson, P.1    Anderson, K.2
  • 47
    • 1942534043 scopus 로고    scopus 로고
    • The evolution of thalidomide and its IMiD derivatives as anticancer agents
    • Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer 2004;4:314-322.
    • (2004) Nat Rev Cancer , vol.4 , pp. 314-322
    • Bartlett, J.B.1    Dredge, K.2    Dalgleish, A.G.3
  • 48
    • 0036381106 scopus 로고    scopus 로고
    • Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during costimulation of both CD4(+) and CD8(+) T cells
    • Marriott JB, Clarke IA, Dredge K, Muller G, Stirling D, Dalgleish AG. Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during costimulation of both CD4(+) and CD8(+) T cells. Clin Exp Immunol 2002;130:75-84.
    • (2002) Clin Exp Immunol , vol.130 , pp. 75-84
    • Marriott, J.B.1    Clarke, I.A.2    Dredge, K.3    Muller, G.4    Stirling, D.5    Dalgleish, A.G.6
  • 49
    • 10744231369 scopus 로고    scopus 로고
    • Immunomodulatory drug costimulates T cells via the B7-CD28 pathway
    • LeBlanc R, Hideshima T, Catley LP, et al. Immunomodulatory drug costimulates T cells via the B7-CD28 pathway. Blood 2004;103:1787-1790.
    • (2004) Blood , vol.103 , pp. 1787-1790
    • Leblanc, R.1    Hideshima, T.2    Catley, L.P.3
  • 50
    • 0038476461 scopus 로고    scopus 로고
    • Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs
    • Schafer PH, Gandhi AK, Loveland MA, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther 2003;305:1222-1232.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 1222-1232
    • Schafer, P.H.1    Gandhi, A.K.2    Loveland, M.A.3
  • 51
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay AG, Johnson AJ, Lee AM, et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 2008;118:2427-2437.
    • (2008) J Clin Invest , vol.118 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3
  • 52
    • 74949120453 scopus 로고    scopus 로고
    • Lenalidomide repairs suppressed T cell immunological synapse formation in follicular lymphoma
    • Abstract
    • Ramsay AG, Clear AJ, Fatah R, Gribben JG. Lenalidomide repairs suppressed T cell immunological synapse formation in follicular lymphoma. Blood 2008;112(Suppl.):885 (Abstract).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 885
    • Ramsay, A.G.1    Clear, A.J.2    Fatah, R.3    Gribben, J.G.4
  • 53
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001;98:210-216.
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 54
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
    • Hideshima T, Chauhan D, Shima Y, et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 2000;96: 2943-2950.
    • (2000) Blood , vol.96 , pp. 2943-2950
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3
  • 55
    • 34249740754 scopus 로고    scopus 로고
    • Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors
    • Epling-Burnette PK, Bai F, Painter JS, et al. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 2007;109:4816-4824.
    • (2007) Blood , vol.109 , pp. 4816-4824
    • Epling-Burnette, P.K.1    Bai, F.2    Painter, J.S.3
  • 56
    • 39849099704 scopus 로고    scopus 로고
    • An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome
    • Ebert BL, Galili N, Tamayo P, et al. An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome. PLoS Med 2008;5:e35.
    • (2008) PLoS Med , vol.5
    • Ebert, B.L.1    Galili, N.2    Tamayo, P.3
  • 57
    • 34547474047 scopus 로고    scopus 로고
    • Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q-syndrome patients
    • Pellagatti A, Jadersten M, Forsblom AM, et al. Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q-syndrome patients. Proc Natl Acad Sci USA 2007;104:11406-11411.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11406-11411
    • Pellagatti, A.1    Jadersten, M.2    Forsblom, A.M.3
  • 58
    • 74949110293 scopus 로고    scopus 로고
    • Lenalidomide abrogates the protective influence of nurse-like cells on primary chronic lymphocytic leukemia cells in vitro
    • Abstract
    • James DF, Betty MR, Mosadeghi R, Kipps TJ. Lenalidomide abrogates the protective influence of nurse-like cells on primary chronic lymphocytic leukemia cells in vitro. Blood 2007;110(Suppl.):3116 (Abstract).
    • (2007) Blood , vol.110 , Issue.SUPPL. , pp. 3116
    • James, D.F.1    Betty, M.R.2    Mosadeghi, R.3    Kipps, T.J.4
  • 59
    • 23844435619 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model
    • Hernandez-Ilizaliturri FJ, Reddy N, Holkova B, Ottman E, Czuczman MS. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res 2005;11:5984-5992.
    • (2005) Clin Cancer Res , vol.11 , pp. 5984-5992
    • Hernandez-Ilizaliturri, F.J.1    Reddy, N.2    Holkova, B.3    Ottman, E.4    Czuczman, M.S.5
  • 60
    • 36849024949 scopus 로고    scopus 로고
    • Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo
    • Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, et al. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo. Br J Haematol 2008;140:36-45.
    • (2008) Br J Haematol , vol.140 , pp. 36-45
    • Reddy, N.1    Hernandez-Ilizaliturri, F.J.2    Deeb, G.3
  • 61
    • 69249140986 scopus 로고    scopus 로고
    • Direct inhibitory effects of lenalidomide on the proliferation and VEGF production of non-hodgkin lymphoma cells are associated with increased SPARC expression
    • Abstract
    • Zhang L-H, Schafer PH, Muller G, Stirling D, Bartlett B. Direct inhibitory effects of lenalidomide on the proliferation and VEGF production of non-hodgkin lymphoma cells are associated with increased SPARC expression. Blood 2008;112(Suppl.):2612 (Abstract).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 2612
    • Zhang, L.-H.1    Schafer, P.H.2    Muller, G.3    Stirling, D.4    Bartlett, B.5
  • 62
    • 74949124477 scopus 로고    scopus 로고
    • Lenalidomide displays direct anti-non-Hodgkin's lymphoma (NHL) cell activity in association with enhanced SPARC expression but independent of its ability to strongly inhibit NHL cell VEGF production in vitro
    • Abstract
    • Zhang L-H, Schafer P, Muller G, Stirling D, Bartlett JB. Lenalidomide displays direct anti-non-Hodgkin's lymphoma (NHL) cell activity in association with enhanced SPARC expression but independent of its ability to strongly inhibit NHL cell VEGF production in vitro. Blood 2007;110(Suppl.): 3473 (Abstract).
    • (2007) Blood , vol.110 , Issue.SUPPL. , pp. 3473
    • Zhang, L.-H.1    Schafer, P.2    Muller, G.3    Stirling, D.4    Bartlett, J.B.5
  • 63
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002;99:4525-4530.
    • (2002) Blood , vol.99 , pp. 4525-4530
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 64
    • 45149115902 scopus 로고    scopus 로고
    • Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia
    • Andritsos LA, Johnson AJ, Lozanski G, et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 2008;26:2519-2525.
    • (2008) J Clin Oncol , vol.26 , pp. 2519-2525
    • Andritsos, L.A.1    Johnson, A.J.2    Lozanski, G.3
  • 65
    • 58149399362 scopus 로고    scopus 로고
    • Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells
    • Lapalombella R, Yu B, Triantafillou G, et al. Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells. Blood 2008;112:5180-5189.
    • (2008) Blood , vol.112 , pp. 5180-5189
    • Lapalombella, R.1    Yu, B.2    Triantafillou, G.3
  • 66
    • 60749120363 scopus 로고    scopus 로고
    • The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia
    • Lapalombella R, Gowda A, Joshi T, et al. The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia. Br J Haematol 2009;144:848-855.
    • (2009) Br J Haematol , vol.144 , pp. 848-855
    • Lapalombella, R.1    Gowda, A.2    Joshi, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.