Phospholipidosis in Neurons Caused by Posaconazole, without Evidence for Functional Neurologic Effects

Toxicologic Pathology

Volumn 37, Issue 7, 2009, Pages 902-910

  Cartwright, Mark E ^a   Petruska, Janet ^a   Arezzo, Joseph ^b   Frank, Doyle ^a   Litwak, Mona ^b   Morrissey, Richard E ^a   Macdonald, James ^a   Davis, Thomas E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

dog; function; neurons; phospholipidosis; posaconazole

Indexed keywords

POSACONAZOLE;

AMPLITUDE MODULATION; ANIMAL CELL; ARTICLE; BASAL GANGLION; BLOOD CLOTTING DISORDER; BRAIN NUCLEUS; BRAIN REGION; CELL MEMBRANE; CELL VACUOLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOPLASM; DRUG DOSE ESCALATION; ELECTROPHYSIOLOGY; EVOKED AUDITORY RESPONSE; EVOKED SOMATOSENSORY RESPONSE; EVOKED VISUAL RESPONSE; FEMALE; HISTOPATHOLOGY; LAMELLAR BODY; LIPIDOSIS; LOW DRUG DOSE; LYSOSOME; MALE; MEDULLA OBLONGATA; NERVE CELL; NERVE CELL DEGENERATION; NERVE CONDUCTION; NERVE FIBER; NERVOUS TISSUE; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; SPINAL CORD; TREATMENT DURATION;

ANIMALS; ANTIFUNGAL AGENTS; DOGS; GANGLIA, SPINAL; LIPIDOSES; MEDULLA OBLONGATA; MYENTERIC PLEXUS; NERVE FIBERS, MYELINATED; NEURONS; PHOSPHOLIPIDS; THALAMUS; TOXICITY TESTS, CHRONIC; TRIAZOLES;

CANIS FAMILIARIS;

EID: 74949128978     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/0192623309348521     Document Type: Article

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