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Volumn 51, Issue 1, 2010, Pages 73-78

Report of a phase 1/2 study of a combination of azacitidine and cytarabine in acute myelogenous leukemia and high-risk myelodysplastic syndromes

Author keywords

Acute myelogenous leukemia; Azacitidine; Cytarabine

Indexed keywords

AZACITIDINE; CYTARABINE;

EID: 74949127345     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428190903318329     Document Type: Article
Times cited : (35)

References (32)
  • 1
    • 7944230161 scopus 로고    scopus 로고
    • Epigenetic silencing mediated by CpG island methylation: Potential as a therapeutic target and as a biomarker
    • Teodoridis JM, Strathdee G, Brown R. Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker. Drug Resist Update 2004;7:267-278.
    • (2004) Drug Resist Update , vol.7 , pp. 267-278
    • Teodoridis, J.M.1    Strathdee, G.2    Brown, R.3
  • 2
    • 0344393732 scopus 로고    scopus 로고
    • Strategies for reversing drug resistance
    • Fojo T, Bates S. Strategies for reversing drug resistance. Oncogene 2003;22:7512-7523.
    • (2003) Oncogene , vol.22 , pp. 7512-7523
    • Fojo, T.1    Bates, S.2
  • 3
    • 51649122312 scopus 로고    scopus 로고
    • Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
    • Kroeger H, Jelinek J, Estecio MR, et al. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood 2008;112:1366-1373.
    • (2008) Blood , vol.112 , pp. 1366-1373
    • Kroeger, H.1    Jelinek, J.2    Estecio, M.R.3
  • 4
    • 33847082188 scopus 로고    scopus 로고
    • DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia
    • Agrawal S, Unterberg M, Koschmieder S, et al. DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia. Cancer Res 2007;67:1370-1377.
    • (2007) Cancer Res , vol.67 , pp. 1370-1377
    • Agrawal, S.1    Unterberg, M.2    Koschmieder, S.3
  • 5
    • 34250213859 scopus 로고    scopus 로고
    • DNA methylation as a therapeutic target in cancer
    • Issa JP. DNA methylation as a therapeutic target in cancer. Clin Cancer Res 2007;13:1634-1637.
    • (2007) Clin Cancer Res , vol.13 , pp. 1634-1637
    • Issa, J.P.1
  • 6
    • 0016223511 scopus 로고
    • Kinetic studies on phosphorylation of 5-azacytidine with the purified uridinecytidine kinase from calf thymus
    • Lee T, Karon M, Momparler RL. Kinetic studies on phosphorylation of 5-azacytidine with the purified uridinecytidine kinase from calf thymus. Cancer Res 1974;34:2482-2488.
    • (1974) Cancer Res , vol.34 , pp. 2482-2488
    • Lee, T.1    Karon, M.2    Momparler, R.L.3
  • 7
    • 0018943517 scopus 로고
    • Altered 5-azacytidine metabolism following 3-deazauridine treatment of L5178Y and human myeloblasts
    • Grant S, Cadman E. Altered 5-azacytidine metabolism following 3-deazauridine treatment of L5178Y and human myeloblasts. Cancer Res 1980;40:4000-4006.
    • (1980) Cancer Res , vol.40 , pp. 4000-4006
    • Grant, S.1    Cadman, E.2
  • 8
    • 0018104806 scopus 로고
    • Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin
    • Plagemann PG, Behrens M, Abraham D. Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin. Cancer Res 1978;38:2458-2466.
    • (1978) Cancer Res , vol.38 , pp. 2458-2466
    • Plagemann, P.G.1    Behrens, M.2    Abraham, D.3
  • 9
    • 0022244733 scopus 로고
    • Azapyrimidine nucleosides: Metabolism and inhibitory mechanisms
    • Cihak A, Vesely J, Skoda J. Azapyrimidine nucleosides: metabolism and inhibitory mechanisms. Adv Enzyme Regul 1985;24:335-354.
    • (1985) Adv Enzyme Regul , vol.24 , pp. 335-354
    • Cihak, A.1    Vesely, J.2    Skoda, J.3
  • 10
    • 0013844503 scopus 로고
    • Incorporation of 5-azacytidine into liver ribonucleic acids of leukemic mice sensitive and resistant to 5-azacytidine
    • Cihak A, Vesely J, Sorm F. Incorporation of 5-azacytidine into liver ribonucleic acids of leukemic mice sensitive and resistant to 5-azacytidine. Biochim Biophys Acta 1965;108:516-518.
    • (1965) Biochim Biophys Acta , vol.108 , pp. 516-518
    • Cihak, A.1    Vesely, J.2    Sorm, F.3
  • 11
    • 0016430355 scopus 로고
    • Effects of 5-azacytidine on nucleolar RNA and the preribosomal particles in Novikoff hepatoma cells
    • Weiss JW, Pitot HC. Effects of 5-azacytidine on nucleolar RNA and the preribosomal particles in Novikoff hepatoma cells. Biochemistry 1975;14:316-326.
    • (1975) Biochemistry , vol.14 , pp. 316-326
    • Weiss, J.W.1    Pitot, H.C.2
  • 12
    • 0016240205 scopus 로고
    • Biological effects of 5-azacytidine in eukaryotes
    • Cihak A. Biological effects of 5-azacytidine in eukaryotes. Oncology 1974;30:405-422.
    • (1974) Oncology , vol.30 , pp. 405-422
    • Cihak, A.1
  • 13
    • 0019510628 scopus 로고
    • Reactivation of an inactive human X chromosome: Evidence for X inactivation by DNA methylation
    • Mohandas T, Sparkes RS, Shapiro LJ. Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation. Science 1981;211:393-396.
    • (1981) Science , vol.211 , pp. 393-396
    • Mohandas, T.1    Sparkes, R.S.2    Shapiro, L.J.3
  • 14
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980;20:85-93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 15
    • 0020032366 scopus 로고
    • Inhibition of DNA methyltransferase and induction of friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-20-deoxycytidine
    • Creusot F, Acs G, Christman JK. Inhibition of DNA methyltransferase and induction of friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-20-deoxycytidine. J Biol Chem 1982;257:2041-2048.
    • (1982) J Biol Chem , vol.257 , pp. 2041-2048
    • Creusot, F.1    Acs, G.2    Christman, J.K.3
  • 16
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman LR, McKenzie DR, Peterson BL, et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 2006;24:3895-3903.
    • (2006) J Clin Oncol , vol.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 17
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
    • Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002;20:2429-2440.
    • (2002) J Clin Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 18
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009;10:223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 19
    • 0345628622 scopus 로고    scopus 로고
    • Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia
    • Schroder JK, Kirch C, Seeber S, Schutte J. Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia. Br J Haematol 1998;103:1096-1103.
    • (1998) Br J Haematol , vol.103 , pp. 1096-1103
    • Schroder, J.K.1    Kirch, C.2    Seeber, S.3    Schutte, J.4
  • 20
    • 0015236586 scopus 로고
    • Cytidine deaminase and the development of resistance to arabinosyl cytosine
    • Steuart CD, Burke PJ. Cytidine deaminase and the development of resistance to arabinosyl cytosine. Nat New Biol 1971;233:109-110.
    • (1971) Nat New Biol , vol.233 , pp. 109-110
    • Steuart, C.D.1    Burke, P.J.2
  • 21
    • 0030971066 scopus 로고    scopus 로고
    • Sensitivity of acute leukemia cells to cytarabine is a correlate of cellular es nucleoside transporter site content measured by flow cytometry with SAENTA-fluorescein
    • Gati WP, Paterson AR, Larratt LM, Turner AR, Belch AR. Sensitivity of acute leukemia cells to cytarabine is a correlate of cellular es nucleoside transporter site content measured by flow cytometry with SAENTA-fluorescein. Blood 1997;90: 346-353.
    • (1997) Blood , vol.90 , pp. 346-353
    • Gati, W.P.1    Paterson, A.R.2    Larratt, L.M.3    Turner, A.R.4    Belch, A.R.5
  • 22
    • 0023351150 scopus 로고
    • Deoxycytidine kinase and deoxycytidine deaminase values correspond closely to clinical response to cytosine arabinoside remission induction therapy in patients with acute myelogenous leukemia
    • Colly LP, Peters WG, Richel D, Arentsen-Honders MW, Starrenburg CW, Willemze R. Deoxycytidine kinase and deoxycytidine deaminase values correspond closely to clinical response to cytosine arabinoside remission induction therapy in patients with acute myelogenous leukemia. Semin Oncol 1987;14(2 Suppl 1):257-261.
    • (1987) Semin Oncol , vol.14 , Issue.2 SUPPL. 1 , pp. 257-261
    • Colly, L.P.1    Peters, W.G.2    Richel, D.3    Arentsen-Honders, M.W.4    Starrenburg, C.W.5    Willemze, R.6
  • 23
    • 0021719254 scopus 로고
    • Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-b-D- arabinofuranosylcytosine
    • Bhalla K, Nayak R, Grant S. Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-b-D-arabinofuranosylcytosine. Cancer Res 1984;44:5029-5037.
    • (1984) Cancer Res , vol.44 , pp. 5029-5037
    • Bhalla, K.1    Nayak, R.2    Grant, S.3
  • 24
    • 34547125965 scopus 로고    scopus 로고
    • Effect of cytarabine and decitabine in combination in human leukemic cell lines
    • Qin T, Youssef EM, Jelinek J, et al. Effect of cytarabine and decitabine in combination in human leukemic cell lines. Clin Cancer Res 2007;13:4225-4232.
    • (2007) Clin Cancer Res , vol.13 , pp. 4225-4232
    • Qin, T.1    Youssef, E.M.2    Jelinek, J.3
  • 25
    • 60249094793 scopus 로고    scopus 로고
    • Mechanisms of resistance to 5-aza-20-deoxycytidine in human cancer cell lines
    • Qin T, Jelinek J, Si J, Shu J, Issa JP. Mechanisms of resistance to 5-aza-20-deoxycytidine in human cancer cell lines. Blood 2009;113:659-667.
    • (2009) Blood , vol.113 , pp. 659-667
    • Qin, T.1    Jelinek, J.2    Si, J.3    Shu, J.4    Issa, J.P.5
  • 26
    • 34547659861 scopus 로고    scopus 로고
    • A parallel phase I/II clinical trial design for combination therapies
    • Huang X, Biswas S, Oki Y, Issa JP, Berry DA. A parallel phase I/II clinical trial design for combination therapies. Biometrics 2007;63:429-436.
    • (2007) Biometrics , vol.63 , pp. 429-436
    • Huang, X.1    Biswas, S.2    Oki, Y.3    Issa, J.P.4    Berry, D.A.5
  • 27
    • 1542753559 scopus 로고    scopus 로고
    • Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
    • Cheson BD, Bennett JM, Kopecky KJ, et al. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J Clin Oncol 2003;21:4642-4649.
    • (2003) J Clin Oncol , vol.21 , pp. 4642-4649
    • Cheson, B.D.1    Bennett, J.M.2    Kopecky, K.J.3
  • 28
    • 0034554786 scopus 로고    scopus 로고
    • Report of an international working group to standardize response criteria for myelodysplastic syndromes
    • Cheson BD, Bennett JM, Kantarjian H, et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes. Blood 2000;96:3671-3674.
    • (2000) Blood , vol.96 , pp. 3671-3674
    • Cheson, B.D.1    Bennett, J.M.2    Kantarjian, H.3
  • 29
    • 0024355064 scopus 로고
    • Pharmacodynamic and DNA methylation studies of high-dose 1-b-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia
    • Avramis VI, Mecum RA, Nyce J, Steele DA, Holcenberg JS. Pharmacodynamic and DNA methylation studies of high-dose 1-b-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia. Cancer Chemother Pharmacol 1989;24:203-210.
    • (1989) Cancer Chemother Pharmacol , vol.24 , pp. 203-210
    • Avramis, V.I.1    Mecum, R.A.2    Nyce, J.3    Steele, D.A.4    Holcenberg, J.S.5
  • 30
    • 0017254616 scopus 로고
    • Combination chemotherapy of L1210 leukemia with 1-b-D- arabinofuranosylcytosine and 5-azacytidine
    • Neil GL, Berger AE, Bhuyan BK, DeSante DC. Combination chemotherapy of L1210 leukemia with 1-b-D-arabinofuranosylcytosine and 5-azacytidine. Cancer Res 1976;36:1114-1120.
    • (1976) Cancer Res , vol.36 , pp. 1114-1120
    • Neil, G.L.1    Berger, A.E.2    Bhuyan, B.K.3    Desante, D.C.4
  • 31
    • 0016776805 scopus 로고
    • In vitro biochemical and cytotoxicity studies with 1-b-D- arabinofuranosylcytosine and 5-azacytidine in combination
    • Momparler RL, Goodman J, Karon M. In vitro biochemical and cytotoxicity studies with 1-b-D-arabinofuranosylcytosine and 5-azacytidine in combination. Cancer Res 1975;35:2853-2857.
    • (1975) Cancer Res , vol.35 , pp. 2853-2857
    • Momparler, R.L.1    Goodman, J.2    Karon, M.3
  • 32
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-20-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa JP, Garcia-Manero G, Giles FJ, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-20-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004;103:1635-1640.
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3


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