2-Amino-nonyl-6-methoxyl-tetralin muriate inhibits sterol C-14 reductase in the ergosterol biosynthetic pathway

Acta Pharmacologica Sinica

Volumn 30, Issue 12, 2009, Pages 1709-1716

  Liang, Rong Mei ^a,b   Cao, Yong Bing ^a   Fan, Kai Hua ^b   Xu, Yi ^a   Gao, Ping Hui ^a   Zhou, You Jun ^a   Dai, Bao Di ^c   Tan, Yong Hong ^b   Wang, Shi Hua ^b   Tang, Hui ^a   Liu, Hong Tao ^d   Jiang, Yuan Ying ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b CHENGDU MILITARY GENERAL HOSPITAL   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

2 amino nonyl 6 methoxyl tetralin muriate; Candida albicans; Ergosterol; Sterol C 14 reducase

Indexed keywords

2 AMINO NONYL 6 METHOXYL TETRALIN MURIATE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIFUNGAL AGENT; ERGOSTEROL; FENPROPIMORPH; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; MESSENGER RNA; OXIDOREDUCTASE; PHENAZINE METHOSULFATE; STEROL C 14 REDUCTASE; STEROL DERIVATIVE; TETRALIN DERIVATIVE; TRANSCRIPTION FACTOR ERG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIFUNGAL ACTIVITY; ANTIFUNGAL RESISTANCE; ARTICLE; BROTH DILUTION; CANDIDA ALBICANS; CELL ASSAY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; FIBROBLAST; FUNGAL STRAIN; FUNGUS CULTURE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIPID COMPOSITION; LIVER CELL; MASS FRAGMENTOGRAPHY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEROL METABOLISM; STEROL SYNTHESIS; STRAIN DIFFERENCE; UPREGULATION;

ANIMALS; ANTIFUNGAL AGENTS; AZOLES; BALB 3T3 CELLS; BIOSYNTHETIC PATHWAYS; CANDIDA ALBICANS; ERGOSTEROL; HEPATOCYTES; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; MICROBIAL SENSITIVITY TESTS; OXIDOREDUCTASES; STEROLS; TETRAHYDRONAPHTHALENES; UP-REGULATION;

EID: 74949115913     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.157     Document Type: Article

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