Glycogenic hepatopathy: A rare cause of elevated serum transaminases in diabetes mellitus

Netherlands Journal of Medicine

Volumn 67, Issue 11, 2009, Pages 394-396

  Van Den Brand, M ^a   Elving, L D ^a   Drenth, J P H ^a   Van Krieken, J H J M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Glycogenic hepatopathy; Liver glycogenosis; Mauriac syndrome; Type 1 diabetes mellitus

Indexed keywords

AMINOTRANSFERASE;

ADULT; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CASE REPORT; DISEASE ASSOCIATION; FEMALE; GLYCOGENIC LIVER DISEASE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIVER DISEASE; LIVER HISTOLOGY;

ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BIOPSY; CAUSALITY; DIABETES MELLITUS, TYPE 1; DIAGNOSIS, DIFFERENTIAL; FATTY LIVER, ALCOHOLIC; FEMALE; HUMANS; LIVER DISEASES; LIVER FUNCTION TESTS; LIVER GLYCOGEN; PROGNOSIS; RARE DISEASES;

EID: 74849137810     PISSN: 03002977     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346:1221-31.
2. Mauriac P. Gros ventre, hepatomegalie, troubles de las croissance chez les enfants diabetiques traits depuis plesieurs annes par l'insuline. Gaz Hebd Med Bordeaux. 1930;26:402-10.
3. Torbenson M, Chen YY, Brunt E, et al. Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus. Am J Surg Pathol. 2006;30:508-13.
4. Chatila R, West AB. Hepatomegaly and abnormal liver tests due to glycogenosis in adults with diabetes. Medicine (Baltimore). 1996;75:327-33.
5. Nakamuta M, Ohashi M, Goto K, Tanabe Y, Hiroshige K, Nawata H. Diabetes mellitus-associated glycogen storage hepatomegaly: report of a case and review of the Japanese literature. Fukuoka Igaku Zasshi. 1993;84:354-8.
6. Carcione L, Lombardo F, Messina MF, Rosano M, de Luca F. Liver glycogenosis as early manifestation in type 1 diabetes mellitus. Diabetes Nutr Metab. 2003;16:182-4.
7. Torres M, Lopez D. Liver glycogen storage associated with uncontrolled type 1 diabetes mellitus. J Hepatol. 2001;35:538.
8. Cuthbertson DJ, Brennan G, Walsh S, Henry E. Hepatic glycogenosis: abnormal liver function tests in Type 1 diabetes. Diabet Med. 2007;24:322-3.
9. Fridell JA, Saxena R, Chalasani NP, Goggins WC, Powelson JA, Cummings OW. Complete reversal of glycogen hepatopathy with pancreas transplantation: two cases. Transplantation. 2007;83:84-6.
10. Hudacko RM, Manoukian AV, Schneider SH, Fyfe B. Clinical resolution of glycogenic hepatopathy following improved glycemic control. J Diabetes Complications. 2008;22:329-30.
11. Sayuk GS, Elwing JE, Lisker-Melman M. Hepatic glycogenosis: an underrecognized source of abnormal liver function tests? Dig Dis Sci. 2007;52:936-8.
12. Martocchia A, Risicato MG, Mattioli C, Antonelli M, Ruco L, Falaschi P. Association of diffuse liver glycogenosis and mild focal macrovesicular steatosis in a patient with poorly controlled type 1 diabetes. Intern Emerg Med. 2008;3:273-4.
13. Tsujimoto T, Takano M, Nishiofuku M, et al. Rapid onset of glycogen storage hepatomegaly in a type-2 diabetic patient after a massive dose of long-acting insulin and large doses of glucose. Intern Med. 2006;45:469-73.
14. Bassett JT, Veerappan GR, Lee DH. Glycogenic hepatopathy: a rare cause of increased aminotransferase levels in a diabetic patient. Clin Gastroenterol Hepatol. 2008;6:A26.
15. Munns CF, McCrossin RB, Thomsett MJ, Batch J. Hepatic glycogenosis: reversible hepatomegaly in type 1 diabetes. J Paediatr Child Health. 2000;36:449-52.
16. Abaci A, Bekem O, Unuvar T, et al. Hepatic glycogenosis: a rare cause of hepatomegaly in Type 1 diabetes mellitus. J Diabetes Complications. 2008;22:325-8.
17. Ferrer JC, Favre C, Gomis RR, et al. Control of glycogen deposition. FEBS Lett. 2003;546:127-32.
18. Brar D. The history of insulin. 2009. http://www.med.uni-giessen.de/itr/ history/inshist.html.
19. Roach PJ. Glycogen and its metabolism. Curr Mol Med. 2002;2:101-20.