Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CONTROLLED STUDY;
DRUG CYTOTOXICITY;
DRUG MECHANISM;
DRUG POTENCY;
DRUG POTENTIATION;
ENDOPLASMIC RETICULUM STRESS;
ENZYME INHIBITION;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
LYMPHOMA CELL;
PRIORITY JOURNAL;
RAJI CELL;
Calcium-activated ER stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib (DMC), a non-coxib analog of celecoxib
Pyrko P., Kardosh A., Liu Y.T., Soriano N., Xiong W., Chow R.H., et al. Calcium-activated ER stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib (DMC), a non-coxib analog of celecoxib. Mol Cancer Ther 6 (2007) 1262-1275
Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo
Kardosh A., Wang W., Uddin J., Petasis N.A., Hofman F., Chen C.C., et al. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo. Cancer Biol Ther 4 (2005) 571-582
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells
Nawrocki S.T., Carew J.S., Dunner Jr. K., Boise L.H., Chiao P.J., Huang P., et al. Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. Cancer Res 65 (2005) 11510-11519