Developmental changes in hepatic antioxidant capacity are age- and sex-dependent

Journal of Pharmacological Sciences

Volumn 111, Issue 4, 2009, Pages 440-445

  Miyagi, Shogo J ^a   Brown, Isaac W ^a   Chock, Jessica M L ^a   Collier, Abby C ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

Detoxification enzyme; Oxidative stress; Pediatric liver disease

Indexed keywords

ALPHA TOCOPHEROL; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; SUPEROXIDE DISMUTASE; THIOREDOXIN REDUCTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; LIVER; ORGAN DONOR; SEX DIFFERENCE;

EID: 74849100359     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.09223SC     Document Type: Article

References (15)

1. Aboutwerat A, Pemberton PW, Smith A, Burrows PC, McMahon RF, Jain SK, et al. Oxidant stress is a significant feature of primary biliary cirrhosis. Biochim Biophys Acta. 2003;1637:147-150.
2. Tsukahara H. Biomarkers of oxidative stress: clinical application in pediatric medicine. Curr Med Chem. 2007;14:339-351.
3. Guillouzo A, Morel F, Fardel O, Meunier B. Use of human hepatocyte cultures for drug metabolism studies. Toxicology. 1993;82:209-219.
4. Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-Transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249:7130-7139.
5. Ernster L, Lind C, Rase B. A study of the DT-diaphorase activity of warfarin-resistant rats. Eur J Biochem. 1972;25:198-206.
6. Nagasaka H, Inoue I, Inui A, Komatsu H, Sogo T, Murayama K, et al. Relationship between oxidative stress and antioxidant systems in the liver of patients with Wilson disease: hepatic manifestation in Wilson disease as a consequence of augmented oxidative stress. Pediatr Res. 2006;60:472-477.
7. Henrion-Caude A, Flamant C, Roussey M, Housset C, Flahault A, Fryer A, et al. Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism. Hepatology. 2002;36:913-917.
8. Debier C. Vitamin E during pre- and postnatal periods. Vitam Horm. 2007;76:357-373.
9. Tütem E, Apak R, Günaydi E, Sözgen K. Spectrophotometric determination of vitamin E (-tocopherol) using copper(II)-neocuproine reagent. Talanta. 1997;44:249-255.
10. Omaye ST, Turnbull JD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol. 1979;62:3-11.
11. Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A. 1999;96:7220-7225.
12. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51-88.
13. Dwivedi S, Sharma A, Patrick B, Sharma R, Awasthi YC. Role of 4-hydroxynonenal and its metabolites in signaling. Redox Rep. 2007;12:4-10.
14. Strassburg CP, Strassburg A, Kneip S, Barut A, Tukey RH, Rodek B, et al. Developmental aspects of human hepatic drug glucuronidation in young children and adults. Gut. 2002;50:259-265.
15. Bezerra J. The next challenge in pediatric cholestasis: deciphering the pathogenesis of biliary atresia. J Pediatr Gastroenterol Nutr. 2006;43 Suppl 1:S23-S29.