A simple and rapid high-performance liquid chromatography method for determination of alendronate sodium in beagle dog plasma with application to preclinical pharmacokinetic study

Biomedical Chromatography

Volumn 24, Issue 2, 2010, Pages 169-173

  Meng, Jian ^a   Meng, Qiang ^b   Zheng, Liangyuan ^c  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Alendronate sodium; Derivatization; O phthalaldehyde; Pharmacokinetics; Plasma

Indexed keywords

CHLORINE COMPOUNDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; QUALITY CONTROL; SODIUM; SODIUM HYDROXIDE;

ALENDRONATE; ALENDRONATE SODIUMS (ALN); BEAGLE DOG; DERIVATIZATIONS; DOG PLASMA; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; O-PHTHALALDEHYDE; PHARMACOKINETIC STUDIES; SIMPLE++;

PHARMACOKINETICS;

ACETONITRILE; ALENDRONIC ACID; CALCIUM CHLORIDE; EDETATE SODIUM; PAMIDRONIC ACID; PHTHALALDEHYDE; SODIUM HYDROXIDE;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CHROMATOGRAPHY; DERIVATIZATION; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; FLUOROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRECIPITATION; REPRODUCIBILITY; VALIDATION STUDY;

CANIS FAMILIARIS;

EID: 74849095187     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1266     Document Type: Article

References (9)

1. Beketov V, Voronina D and Filatova DJ. Spectrophotometric and fluorimetric determination of amino acids by their reaction with ophthalic aldehyde in the presence of sulfite and cyanide ions. Journal of Analytical Chemistry 2000; 55: 1148-1151.
2. Jeal W, Barradell LB and McTavish D. Alendronate. A review of its pharmacological properties and therapeutic efficacy in postmenopausal osteoporosis. Drugs 1997; 53: 415-434.
3. Kline WF and Matuszewski BK. Improved determination of the bisphosphonate alendronate in human plasma and urine by automated precolumn derivatization and high-performance liquid chromatography with fluorescence and electrochemical detection. Journal of Chromatography 1992; 583: 183-193.
4. Lin J. Bisphosphonates: a review of their pharmacokinetic properties. Bone 1996; 18: 75-85.
5. Porras AG, Holland SD and Gertz BJ. Pharmacokinetics of alendronate. Clinical Pharmacokinetics 1999; 36: 315-328.
6. Sparidans RW and Hartigh JD. Chromatographic analysis of bisphorphonates. Pharmacy World and Science 1999; 21: 1-10.
7. United States Food and Drug Administration (FDA). Guidance for Industry: Bioanalytical Method Validation. 2001. Available from: http://www.fda.gov/cder/guidance/index.htm.
8. Yun MH and Kwon K. High-performance liquid chromatography method for determining alendronate sodium in human plasma by detecting fluorescence: application to a pharmacokinetic study in humans. Journal of Pharmaceutical & Biomedical Analysis 2006; 40: 168-172.
9. Zacharis CK and Tzanavaras PD. Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological material: a review of analytical methods. Journal of Pharmaceutical and Biomedical Analysis 2008; 48: 483-496.