Biotin derivatives carrying two chelating DOTA units. Synthesis, in vitro evaluation of biotinidases resistance, avidin binding, and radiolabeling tests

Journal of Medicinal Chemistry

Volumn 53, Issue 1, 2010, Pages 432-440

  Pratesi, Alessandro ^a   Bucelli, Francesca ^a,d   Mori, Ilaria ^a,e   Chinol, Marco ^b   Verdoliva, Antonio ^c   Paganelli, Giovanni ^b   Rivieccio, Vincenzo ^c   Gariboldi, Lucia ^b   Ginanneschi, Mauro ^a  

^a Department of Organic Chemistry Ugo Schiff   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c Tecnogen SpA   (Italy)

^d Department of Public Health ^*  (Italy)

^e NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 4 AMINOBENZOIC ACID; 4' HYDROXYAZOBENZENE 2 CARBOXYLIC ACID; AVIDIN; BIOTIN 4 AMINOBENZOIC ACID 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID Y 90 CONJUGATE; BIOTIN DERIVATIVE; BIOTINIDASE; CARBOXYL GROUP; FUNCTIONAL GROUP; HEXYLAMINE; LYSINE; MOLECULAR SCAFFOLD; RESIN; UNCLASSIFIED DRUG; YTTRIUM 90;

ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; DRUG CONJUGATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; IN VITRO STUDY; ISOTOPE LABELING; PROTEIN BINDING; RADIATION DOSE; RADIOIMMUNOTHERAPY; THERMOSTABILITY;

ANIMALS; AVIDIN; BINDING SITES; BIOTIN; CHELATING AGENTS; ISOTOPE LABELING; MICE; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS;

EID: 74849093140     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9014372     Document Type: Article

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