Hemoglobin levels predict exercise performance, ST-segment depression, and outcome in patients referred for routine exercise treadmill testing

Clinical Cardiology

Volumn 32, Issue 12, 2009, Pages

  Lipinski, Michael J ^a   Dewey, Frederick E ^b   Biondi Zoccai, Giuseppe G ^c   Abbate, Antonio ^c   Vetrovec, George W ^c,d   Froelicher, Victor F ^b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b STANFORD UNIVERSITY   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiovascular events; Exercise testing; Hemoglobin; Mortality

Indexed keywords

HEMOGLOBIN;

ADULT; ANEMIA; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; EXERCISE TEST; FOLLOW UP; HEMOGLOBIN BLOOD LEVEL; HUMAN; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PROPORTIONAL HAZARDS MODEL; ST SEGMENT DEPRESSION; TREADMILL EXERCISE;

AGE FACTORS; ANEMIA; BODY MASS INDEX; CARDIOTONIC AGENTS; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; ELECTROCARDIOGRAPHY; EXERCISE TEST; EXERCISE TOLERANCE; FOLLOW-UP STUDIES; HEMOGLOBINS; HUMANS; HYPERTENSION; KIDNEY DISEASES; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; UNITED STATES;

EID: 74849086383     PISSN: 01609289     EISSN: 19328737     Source Type: Journal    
DOI: 10.1002/clc.20418     Document Type: Article

References (26)

1. Prakash M, Myers J, Froelicher VF, Marcus R, Do D, et al.: Clinical and exercise test predictors of all-cause mortality: Results from>6,000 consecutive referredmale patients. Chest. 2001;120(3): 1003-1013.
2. Raxwal V, Shetler K, Morise A, Do D, Myers J, et al.: Simple treadmill score to diagnose coronary disease. Chest. 2001;119(6): 1933-1940.
3. Lipinski M, Froelicher V, Atwood E, Tseitlin A, Franklin B, et al.: Comparison of treadmill scores with physician estimates of diagnosis and prognosis in patients with coronary artery disease. Am Heart J. 2002;143(4):650-658.
4. Myers J, Prakash M, Froelicher V, Do D, Partington S, et al.: Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346(11):793-801.
5. Silverberg DS,Wexler D, Blum M, Iaina A: The cardiorenal anemia syndrome: Correcting anemia in patients with resistant congestive heart failure can improve both cardiac and renal function and reduce hospitalizations. Clin Nephrol. 2003;60(1):S93-S102.
6. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Borenstein J: Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol. 2002;39(11):1780-1786 .
7. Langston RD, Presley R, Flanders WD, McClellan WM: Renal insufficiency and anemia are independent risk factors for death among patients with acute myocardial infarction. Kidney Int. 2003;64(4):1398-1405 .
8. Alpert BS, Gilman PA, Strong WB, Ellison MF, Miller MD, et al.: Hemodynamic and ECG responses to exercise in children with sickle cell anemia. Am J Dis Child. 1981;135(4):362-366 .
9. Mani A, Singh T, Calton R, Chacko B, Cherian B: Cardiovascular response in anemia. Indian J Pediatr. 2005;72(4):297-300.
10. Canadian Erythropoietin Study Group: Association between recombinant human erythropoietin and quality of life and exercise capacity of patients receiving haemodialysis. BMJ. 1990;300(6724): 573-578 .
11. Mancini DM, Katz SD, Lang CC, LaManca J, Hudaihed A, et al.: Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure. Circulation. 2003;107(2): 294-299 .
12. Metra M, Cannella G, La Canna G, Guaini T, Sandrini M, et al.: Improvement in exercise capacity after correction of anemia in patients with end-stage renal failure. Am J Cardiol. 1991;68(10): 1060-1066 .
13. Wizemann V, Kaufmann J, Kramer W: Effect of erythropoietin on ischemia tolerance in anemichemodialysis patients with confirmed coronary artery disease. Nephron. 1992;62(2):161-165.
14. Zakai NA, Katz R, Hirsch C, Shlipak MG, Chaves PH, et al.: A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: The Cardiovascular Health Study. Arch Intern Med. 2005;165(19):2214-2220.
15. McKechnie RS, Smith D, Montoye C, Kline-Rogers E, O'Donnell MJ, et al.: Prognostic implication of anemia on in-hospital outcomes after percutaneous coronary intervention. Circulation. 2004;110(3):271-277.
16. Anderson JL, Ronnow BS, Horne BD, Carlquist JF, May HT, et al.: Usefulness of a complete blood count-derived risk score to predict incidentmortality in patients with suspected cardiovascular disease. Am J Cardiol. 2007;99(2):169-174.
17. Sabatine MS, Morrow DA, Giugliano RP, Burton PB, Murphy SA, et al.: Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation. 2005;111(16):2042-2049.
18. Nutritional anaemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5-37.
19. Myers J, Buchanan N, Smith D, Neutel J, Bowes E, et al.: Individualized ramp treadmill. Observations on a new protocol. Chest. 1992;101(5):236S-241S.
20. Myers J, Do D, Herbert W, Ribisl P, Froelicher VF: A nomogram to predict exercise capacity from a specific activity questionnaire and clinical data. Am J Cardiol. 1994;73(8):591-596.
21. Mark DB, Shaw L, Harrell FE Jr, Hlatky MA, Lee KL, et al.: Prognostic value of a treadmill exercise score in outpatients with suspected coronary artery disease. N Engl J Med. 1991;325(12): 849-853.
22. Concato J, Feinstein AR, Holford TR: The risk of determining risk with multivariable models. Ann Intern Med. 1993;118(3):201-210.
23. Steyerberg EW, Eijkemans MJ, Harrell FE Jr, Habbema JD: Prognostic modeling with logistic regression analysis: In search of a sensible strategy in small data sets. Med Decis Making. 2001;21(1):45-56.
24. Phrommintikul A, Haas SJ, Elsik M, Krum H: Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treatedwith erythropoietin: Ameta-analysis. Lancet. 2007;369(9559):381- 388.
25. Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, et al.: Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006;355(20):2085-2098.
26. Rao SV, Jollis JG, Harrington RA, Granger CB, Newby LK, et al.: Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA. 2004;292(13): 1555-1562.