Blocking platelet/endothelial cell adhesion molecule 1 (PECAM) inhibits disease progression and prevents joint erosion in established collagen antibody-induced arthritis

Experimental and Molecular Pathology

Volumn 88, Issue 1, 2010, Pages 210-215

  Dasgupta, Bidisha ^a   Chew, Tina ^a   deRoche, Alana ^a   Muller, William A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Arthritis; Inflammation; Leukocyte; Mouse model; PECAM; Rheumatoid arthritis

Indexed keywords

CD31 ANTIGEN; COLLAGEN ANTIBODY; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD31; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ARTICULAR CARTILAGE; BONE EROSION; CARTILAGE DEGENERATION; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; JOINT DESTRUCTION; MOUSE; NONHUMAN; PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; SYMPTOM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD31; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; FEMALE; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; JOINTS; MICE; MICE, INBRED DBA; MICE, TRANSGENIC; RECOMBINANT FUSION PROTEINS; SYNOVITIS;

MURINAE; MUS;

EID: 74749100850     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.09.013     Document Type: Article

References (32)

1. Bogen S., Pak J., Garifallou M., Deng X., and Muller W.A. Monoclonal antibody to murine PECAM-1 [CD31] blocks acute inflammation in vivo. J. Exp. Med. 179 (1994) 1059-1064
2. Courtenay J.S., Dallman M.J., Dayan A.D., Martin A., and Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature 283 (1980) 666-668
3. Feldmann M., and Maini R.N. The role of cytokines in the pathogenesis of rheumatoid arthritis. Rheumatology 38 Suppl. 2 (1999) 3-7
4. Graesser D., Solowiej A., Bruckner M., Osterweil E., Juedes A., Davis S., Ruddle N.H., Engelhardt B., and Madri J.A. Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J. Clin. Invest. 109 (2002) 383-392
5. Harlan J.M. Leukocyte-endothelial interactions. Blood 65 (1985) 513-525
6. Ishikawa J., Okada Y., Bird I.N., Jasani B., Spragg J.H., and Yamada T. Use of anti-platelet-endothelial cell adhesion molecule-1 antibody in the control of disease progression in established collagen-induced arthritis in DBA/1J mice. Jpn. J. Pharmacol. 88 (2002) 332-340
7. Kachigian L.M. Collagen antibody-induced arthritis. Nat. Protocols 1 (2006) 2512-2516
8. Kalinowska A., and Losy J. PECAM-1, a key player in neuroinflammation. Eur. J. Neurol. 13 (2006) 1284-1290
9. Kouskoff V., Korganow A.S., Duchatelle V., Degott C., Benoist C., and Mathis D. Organ-specific disease provoked by systemic autoimmunity. Cell 87 (1996) 811-822
10. Kouskoff V., Korganow A.S., Duchatelle V., Degott C., Benoist C., and Mathis D. A new mouse model of rheumatoid arthritis: organ-specific disease provoked by systemic autoimmunity. Ryumachi 37 (1997) 147
11. Liao F., Huynh H.K., Eiroa A., Greene T., Polizzi E., and Muller W.A. Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1. J. Exp. Med. 182 (1995) 1337-1343
12. Liao F., Ali J., Greene T., and Muller W.A. Soluble domain 1 of platelet-endothelial cell adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro and in vivo. J. Exp. Med. 185 (1997) 1349-1357
13. Liao F., Schenkel A.R., and Muller W.A. Transgenic mice expressing different levels of soluble platelet/endothelial cell adhesion molecule-IgG display distinct inflammatory phenotypes. J. Immunol. 163 (1999) 5640-5648
14. Maccioni M., Zeder-Lutz G., Huang H., Ebel C., Gerber P., Hergueux J., Marchal P., Duchatelle V., Degott C., van Regenmortel M., Benoist C., and Mathis D. Arthritogenic monoclonal antibodies from K/BxN mice. J. Exp. Med. 195 (2002) 1071-1077
15. Muller W.A. The role of PECAM-1 [CD31] in leukocyte emigration: studies in vitro and in vivo. J. Leukoc. Biol. 57 (1995) 523-528
16. Muller W.A. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol. 24 (2003) 326-333
17. Muller W.A. Mechanisms of transendothelial migration of leukocytes. Circ. Res. 105 (2009) 223-230
18. Muller W.A., Weigl S.A., Deng X., and Phillips D.M. PECAM-1 is required for transendothelial migration of leukocytes. J. Exp. Med. 178 (1993) 449-460
19. Reinke E.K., Lee J., Zozulya A., Karman J., Muller W.A., Sandor M., and Fabry Z. Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms. J. Neuroimmunol. 186 (2007) 86-93
20. Rijcken E., Mennigen R.B., Schaefer S.D., Laukoetter M.G., Anthoni C., Spiegel H.U., Bruewer M., Senninger N., and Krieglstein C.F. PECAM-1 (CD 31) mediates transendothelial leukocyte migration in experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 293 (2007) G446-G452
21. Schenkel A.R., Chew T.W., and Muller W.A. Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains. J. Immunol. 173 (2004) 6403-6408
22. Schenkel A.R., Chew T.W., Chlipala E., Harbord M.W., and Muller W.A. Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis. Exp. Mol. Pathol. 81 (2006) 23-30
23. Seidman M.A., Chew T.W., Schenkel A.R., and Muller W.A. PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2. PLoS ONE e4316 (2009) 4
24. Tada Y., Koarada S., Morito F., Ushiyama O., Haruta Y., Kanegae F., Ohta A., Ho A., Mak T.W., and Nagasawa K. Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1. Arthritis Rheum. 48 (2003) 3280-3290
25. Tarrant T.K., and Patel D.D. Chemokines and leukocyte trafficking in rheumatoid arthritis. Pathophysiology 13 (2006) 1-14
26. Terato K., Hasty K.A., Cremer M.A., Stuart J.M., Townes A.S., and Kang A.H. Collagen-induced arthritis in mice. Localization of an arthritogenic determinant to a fragment of the type II collagen molecule. J. Exp. Med. 162 (1985) 637-646
27. Terato K., Harper D.S., Griffiths M.M., Hasty D.L., Ye X.J., Cremer M.A., and Seyer J.M. Collagen-induced arthritis in mice: synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen. Autoimmunity 22 (1995) 137-147
28. Van den Berg W.B. Lessons from animal models of arthritis. Curr. Rheumatol. Rep. 4 (2002) 232-239
29. Vaporciyan A.A., Delisser H.M., Yan H.C., Mendiguren I.I., Thom S.R., Jones M.L., Ward P.A., and Albelda S.M. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science 262 (1993) 1580-1582
30. Wong M.X., Hayball J.D., Hogarth P.M., and Jackson D.E. The inhibitory co-receptor, PECAM-1 provides a protective effect in suppression of collagen-induced arthritis. J. Clin. Immunol. 25 (2005) 19-28
31. Wooley P.H., Luthra H.S., Stuart J.M., and David C.S. Type II collagen-induced arthritis in mice: I. Major histocompatibility complex (I region) linkage and antibody correlates. J. Exp. Med. 154 (1981) 688-700
32. Zvaifler N.J., and Firestein G.S. Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum. 37 (1994) 783-789