Association of PPARα gene polymorphisms and lipid serum levels in a Brazilian elderly population

Experimental and Molecular Pathology

Volumn 88, Issue 1, 2010, Pages 197-201

  Chen, Elizabeth Suchi ^a   Mazzotti, Diego Robles ^a   Furuya, Tatiane Katsue ^a   Cendoroglo, Maysa Seabra ^a   Ramos, Luiz Roberto ^a   Araujo, Lara Quirino ^a   Burbano, Rommel Rodriguez ^a   Smith, Marília de Arruda Cardoso ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

HDL and VLDL serum levels; Intron 7; L162V; PPAR polymorphisms; Triglycerides

Indexed keywords

CYTOSINE; GUANINE; HIGH DENSITY LIPOPROTEIN; LEUCINE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; VALINE; VERY LOW DENSITY LIPOPROTEIN; DNA; LIPOPROTEIN;

AGED; ARTICLE; BRAZIL; CARDIOVASCULAR DISEASE; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INTRON; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; NEOPLASM; PROTEIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; GENETIC PREDISPOSITION; GENETICS; HYPERLIPIDEMIA; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGED, 80 AND OVER; BRAZIL; DNA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERLIPIDEMIAS; LINKAGE DISEQUILIBRIUM; LIPIDS; LIPOPROTEINS; MALE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR ALPHA; TRIGLYCERIDES;

EID: 74749092923     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.10.001     Document Type: Article

References (42)

1. Balcerzyk A., Zak I., and Krauze J. Synergistic effect between polymorphisms of PPARA and ABCA1 genes on the premature coronary artery disease. Acta cardiologica. 62 3 (2007) 233-238
2. Bertolucci P.H., Brucki S.M., Campacci S.R., and Juliano Y. The Mini-Mental State Examination in a general population: impact of educational status. Arq. Neuropsiquiatr. 52 1 (1994) 1-7
3. Bertolucci P.H., Okamoto I.H., Brucki S.M., Siviero M.O., Toniolo Neto J., and Ramos L.R. Applicability of the CERAD neuropsychological battery to Brazilian elderly. Arq. Neuropsiquiatr. 59 3-A (2001) 532-536
4. Blay S.L., Ramos L.R., and Mari Jde J. Validity of a Brazilian version of the Older Americans Resources and Services (OARS) mental health screening questionnaire. J. Am. Geriatr. Soc. 36 8 (1988) 687-692
5. Brune S., Kolsch H., Ptok U., Majores M., Schulz A., Schlosser R., Rao M.L., Maier W., and Heun R. Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease. J. Neural. Transm. 110 9 (2003) 1041-1050
6. Chen E.S., Cendoroglo M.S., Ramos L.R., Araujo L.M., Carvalheira G.M., de Labio R.W., Burbano R.R., Payao S.L., and de A.C.S.M. APO A-V-1131T->C polymorphism frequency and its association with morbidity in a Brazilian elderly population. Clin. Chem. Lab. Med. 44 1 (2006) 32-36
7. Cullen P. Evidence that triglycerides are an independent coronary heart disease risk factor. Am. J. Cardiol. 86 9 (2000) 943-949
8. Ding K., Zhou K., He F., and Shen Y. LDA-a java-based linkage disequilibrium analyzer. Bioinformatics. (Oxford,. England). 19 16 (2003) 2147-2148
9. Doney A.S., Fischer B., Lee S.P., Morris A.D., Leese G., and Palmer C.N. Association of common variation in the PPARA gene with incident myocardial infarction in individuals with type 2 diabetes: a Go-DARTS study. Nuclear receptor 3 (2005) 4
10. Emery A.E.H. Methodology in medical genetics: an introduction to statistical methods. 2nd ed (1986), Elsevier Health Sciences 197pp.
11. Evans D., Aberle J., Wendt D., Wolf A., Beisiegel U., and Mann W.A. A polymorphism, L162V, in the peroxisome proliferator-activated receptor alpha (PPARalpha) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitus. J. Mol. Med. 79 4 (2001) 198-204
12. Flavell D.M., Pineda Torra I., Jamshidi Y., Evans D., Diamond J.R., Elkeles R.S., Bujac S.R., Miller G., Talmud P.J., Staels B., and Humphries S.E. Variation in the PPARalpha gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects. Diabetologia 43 5 (2000) 673-680
13. Flavell D.M., Jamshidi Y., Hawe E., Pineda Torra I., Taskinen M.R., Frick M.H., Nieminen M.S., Kesaniemi Y.A., Pasternack A., Staels B., Miller G., Humphries S.E., Talmud P.J., and Syvanne M. Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease. Circulation 105 12 (2002) 1440-1445
14. Flavell D.M., Ireland H., Stephens J.W., Hawe E., Acharya J., Mather H., Hurel S.J., and Humphries S.E. Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes. Diabetes 54 2 (2005) 582-586
15. Foucher C., Rattier S., Flavell D.M., Talmud P.J., Humphries S.E., Kastelein J.J., Ayyobi A., Pimstone S., Frohlich J., Ansquer J.C., and Steiner G. Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes. Pharmacogenetics 14 12 (2004) 823-829
16. Fruchart-Najib J., Bauge E., Niculescu L.S., Pham T., Thomas B., Rommens C., Majd Z., Brewer B., Pennacchio L.A., and Fruchart J.C. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem. Biophys. Res. Commun. 319 2 (2004) 397-404
17. Garenc C., Aubert S., Laroche J., Girouard J., Vohl M.C., Bergeron J., Rousseau F., and Julien P. Population prevalence of APOE, APOC3 and PPAR-alpha mutations associated to hypertriglyceridemia in French Canadians. J. Hum. Genet. 49 12 (2004) 691-700
18. Gigek Cde O., Chen E.S., Cendoroglo M.S., Ramos L.R., Araujo L.M., Payao S.L., and Smith Mde A. Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels. Clin. Chem. Lab. Med. 45 5 (2007) 599-604
19. Golembesky A.K., Gammon M.D., North K.E., Bensen J.T., Schroeder J.C., Teitelbaum S.L., Neugut A.I., and Santella R.M. Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study. Carcinogenesis 29 10 (2008) 1944-1949
20. Jamshidi Y., Montgomery H.E., Hense H.W., Myerson S.G., Torra I.P., Staels B., World M.J., Doering A., Erdmann J., Hengstenberg C., Humphries S.E., Schunkert H., and Flavell D.M. Peroxisome proliferator-activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Circulation 105 8 (2002) 950-955
21. Kyle U.G., Genton L., Hans D., Karsegard V.L., Michel J.P., Slosman D.O., and Pichard C. Total body mass, fat mass, fat-free mass, and skeletal muscle in older people: cross-sectional differences in 60-year-old persons. J. Am. Geriatr. Soc. 49 12 (2001) 1633-1640
22. Mansur A.P., Favarato D., Souza M.F., Avakian S.D., Aldrighi J.M., Cesar L.A., and Ramires J.A. Trends in death from circulatory diseases in Brazil between 1979 and 1996. Arq. Bras. Cardiol. 76 6 (2001) 497-510
23. Miller O. Bioquímica do Sangue- Substâncias não-eletrolíticas. In: Miller O. (Ed). O Laboratório e os métodos de imagem para o clínico. 5th edn. (2003), Atheneu
24. Oshio H., Abe T., Onogawa T., Ohtsuka H., Sato T., Ii T., Fukase K., Muto M., Katayose Y., Oikawa M., Rikiyama T., Egawa S., and Unno M. Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines. Journal of gastroenterology 43 7 (2008) 538-549
25. Prieur X., Coste H., and Rodriguez J.C. The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element. J. Biol. Chem. 278 28 (2003) 25468-25480
26. Ramos L.R., Toniolo J., Cendoroglo M.S., Garcia J.T., Najas M.S., Perracini M., Paola C.R., Santos F.C., Bilton T., Ebel S.J., Macedo M.B., Almada C.M., Nasri F., Miranda R.D., Goncalves M., Santos A.L., Fraietta R., Vivacqua I., Alves M.L., and Tudisco E.S. Two-year follow-up study of elderly residents in S. Paulo, Brazil: methodology and preliminary results. Rev Saude Publica 32 5 (1998) 397-407
27. Robitaille J., Brouillette C., Houde A., Lemieux S., Perusse L., Tchernof A., Gaudet D., and Vohl M.C. Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome. J. Hum. Genet. 49 9 (2004) 482-489
28. Rolland-Cachera M.F., Cole T.J., Sempe M., Tichet J., Rossignol C., and Charraud A. Body mass index variations: centiles from birth to 87 years. Eur. J. Clin. Nutr. 45 1 (1991) 13-21
29. Sapone A., Peters J.M., Sakai S., Tomita S., Papiha S.S., Dai R., Friedman F.K., and Gonzalez F.J. The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants. Pharmacogenetics 10 4 (2000) 321-333
30. Sjolander A., Minthon L., Bogdanovic N., Wallin A., Zetterberg H., and Blennow K. The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association. Neurobiol. Aging 30 4 (2009) 666-668
31. Skoczynska A., Dobosz T., Poreba R., Turczyn B., Derkacz A., Zoledziewska M., Jonkisz A., and Lebioda A. The dependence of serum interleukin-6 level on PPAR-alpha polymorphism in men with coronary atherosclerosis. Eur. J. Intern. Med. 16 7 (2005) 501-506
32. Sparso T., Hussain M.S., Andersen G., Hainerova I., Borch-Johnsen K., Jorgensen T., Hansen T., and Pedersen O. Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people. Molecular genetics and metabolism 90 2 (2007) 205-209
33. Tai E.S., Demissie S., Cupples L.A., Corella D., Wilson P.W., Schaefer E.J., and Ordovas J.M. Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study. Arterioscler. Thromb. Vasc. Biol. 22 5 (2002) 805-810
34. Tai E.S., Collins D., Robins S.J., O'Connor Jr. J.J., Bloomfield H.E., Ordovas J.M., Schaefer E.J., and Brousseau M.E. The L162V polymorphism at the peroxisome proliferator activated receptor alpha locus modulates the risk of cardiovascular events associated with insulin resistance and diabetes mellitus: the Veterans Affairs HDL Intervention Trial (VA-HIT). Atherosclerosis 187 1 (2006) 153-160
35. Tanaka T., Ordovas J.M., Delgado-Lista J., Perez-Jimenez F., Marin C., Perez-Martinez P., Gomez P., and Lopez-Miranda J. Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men. J. Lipid Res. 48 6 (2007) 1402-1408
36. The DECODE study group. Is fasting glucose sufficient to define diabetes? Epidemiological data from 20 European studies. European Diabetes Epidemiology Group. Diabetes Epidemiology: Collaborative analysis of Diagnostic Criteria in Europe. Diabetologia 42 6 (1999) 647-654
37. Uemura K., and Pisa Z. Recent trends in cardiovascular disease mortality in 27 industrialized countries. World Health Stat. Q. 38 2 (1985) 142-162
38. van Raalte D.H., Li M., Pritchard P.H., and Wasan K.M. Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future. Pharm. Res. 21 9 (2004) 1531-1538
39. Vohl M.C., Lepage P., Gaudet D., Brewer C.G., Betard C., Perron P., Houde G., Cellier C., Faith J.M., Despres J.P., Morgan K., and Hudson T.J. Molecular scanning of the human PPARa gene: association of the L162v mutation with hyperapobetalipoproteinemia. J. Lipid. Res. 41 6 (2000) 945-952
40. Volcik K.A., Nettleton J.A., Ballantyne C.M., and Boerwinkle E. Peroxisome proliferator-activated receptor [alpha] genetic variation interacts with n-6 and long-chain n-3 fatty acid intake to affect total cholesterol and LDL-cholesterol concentrations in the Atherosclerosis Risk in Communities Study. Am. J. Clin. Nutr. 87 6 (2008) 1926-1931
41. Whitworth J.A. World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J. Hypertens. 21 11 (2003) 1983-1992
42. Yong E.L., Li J., and Liu M.H. Single gene contributions: genetic variants of peroxisome proliferator-activated receptor (isoforms alpha, beta/delta and gamma) and mechanisms of dyslipidemias. Curr. Opin. Lipidol. 19 2 (2008) 106-112