Targeting to the hair follicles: Current status and potential

Journal of Dermatological Science

Volumn 57, Issue 2, 2010, Pages 83-89

  Wosicka, Hanna ^a   Cal, Krzysztof ^b  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Drug delivery; Hair follicles; Pilosebaceous unit; Skin permeation

Indexed keywords

3 (4 METHYLBENZYLIDENE)CAMPHOR; 4 AMINOBENZOIC ACID; ADENOSINE; ALDOSTERONE; ALPHA INTERFERON; BRILLIANT GREEN; CAFFEINE; CIMETIDINE; CORTICOSTERONE; CURCUMIN; CYCLOSPORIN A; DEOXYADENOSINE; ESTRADIOL; FINASTERIDE; HYDROCORTISONE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INULIN; LIPOSOME; MELANIN; MINOXIDIL; MYRISTIC ACID; NANOPARTICLE; NIFLUMIC ACID; PODOPHYLLOTOXIN; POLYSTYRENE; RESOMER; TESTOSTERONE; TITANIUM DIOXIDE;

BODY REGIONS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG TARGETING; HAIR ANALYSIS; HAIR CELL; HAIR FOLLICLE; HAIR GROWTH; HAIR ROOT; HUMAN; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PERMEABILITY BARRIER; PRIORITY JOURNAL; REVIEW; SEBUM SECRETION; SKIN PENETRATION; SKIN PERMEABILITY; SKIN STRUCTURE;

ANIMALS; DRUG DELIVERY SYSTEMS; GENE TARGETING; HAIR FOLLICLE; HUMANS; PERMEABILITY;

EID: 74749091096     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2009.12.005     Document Type: Review

References (57)

1. Prausnitz M.R., Mitragotri S., and Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 3 (2004) 115-124
2. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nat Rev Drug Discov 5 (2006) 543-548
3. Karande P., and Mitragotri S. Enhancement of transdermal drug delivery via synergistic action of chemicals. Biochim Biophys Acta 1788 (2009) 2362-2373
4. Morrow D.I.J., McCarron P.A., Woolfson A.D., and Donnelly R.F. Innovative strategies for enhancing topical and transdermal drug delivery. Open Drug Deliv J 1 (2007) 36-59
5. Cal K. Across skin barrier: known methods, new performances. In: Caldwell G.W., Ur-Rahman A., Yan Z., and Choudhary M.I. (Eds). Frontiers in Drug Design and Discovery vol. 4 (2009), Bentham Science Publishers Ltd 162-188
6. Arora A., Prausnitz M.R., and Mitragotri S. Micro-scale devices for transdermal drug delivery. Int J Pharm 364 (2008) 227-236
7. Otberg N., Teichmann A., Rasuljev U., Sinkgraven R., Sterry W., and Lademann J. Follicular penetration of topically applied caffeine via a shampoo formulation. Skin Pharmacol Physiol 20 (2007) 195-198
8. Lademann J., Knorr F., Richter H., Blume-Peytavi U., Vogt A., Antoniou C., et al. Hair follicles - an efficient storage and penetration pathway for topically applied substances. Skin Pharmacol Physiol 21 (2008) 150-155
9. Schaefer H., and Lademann J. The role of follicular penetration. Skin Pharmacol Physiol 14 (2001) 23-27
10. Knorr F., Lademann J., Patzelt A., Sterry W., Blume-Peytavi U., and Vogt A. Follicular transport route - research progress and future perspectives. Eur J Pharm Biopharm 71 (2009) 173-180
11. Vogt A., Hadam S., Heiderhoff M., Audring H., Lademann J., Sterry W., et al. Morphometry of human terminal and vellus hair follicles. Exp Dermatol 16 (2007) 946-950
12. Tobin D.J. Biochemistry of human skin - our brain on the outside. Chem Soc Rev 35 (2006) 52-67
13. Meidan V.C., Bonner M., and Michniak B. Transfollicular drug delivery - is it a reality?. Int J Pharm 306 (2005) 1-14
14. Patzelt A., Knorr F., Blume-Peytavi U., Sterry W., and Lademann J. Hair follicles, their disorders and their opportunities. Drug Discov Today: Dis Mech 5 (2008) 173-181
15. Krause K., and Foitzik K. Biology of the hair follicle: the basics. Semin Cutan Med Surg 25 (2006) 2-10
16. Kertesz Z., Szikszai Z., Pelicon P., Simcic J., Telek A., and Biro T. Ion beam microanalysis of human hair follicles. Nucl Instrum Methods Phys Res B 260 (2007) 218-221
17. Otberg N., Richter H., Schaefer H., Blume-Peytavi U., Sterry W., and Lademann J. Variations of hair follicle size and distribution in different body sites. J Invest Dermatol 122 (2004) 14-19
18. Lademann J., Weigmann H.J., Rickmeyer Ch., Barthelmes H., Schaefer H., Mueller G., et al. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol Physiol 12 (1999) 247-256
19. Knaggs H. Cell biology of the pilosebaceous unit. In: Webster G.F., and Rawlings A.V. (Eds). Acne and its Therapy (2007), Informa Healthcare, New York 12-36
20. Ohyama M., and Vogel J. Gene delivery to the hair follicle. J Invest Dermatol Symp Proc 8 (2003) 204-206
21. Hordinsky M. Advances in hair diseases. Adv Dermatol 24 (2008) 245-259
22. Chase H.B., and Silver A.F. The biology of hair growth. In: Bittar E.E., and Bittar N. (Eds). The Biological Basis of Medicine, Vol. 6, Part I. Hair and Skin (1969), Academic Press, London 3-19
23. MeidanVM, and Touitou E. Treatments for androgenetic alopecia and alopecia areata. Current options and future prospects. Drugs 61 (2001) 53-69
24. Barry B.W. Drug delivery routes in skin: a novel approach. Adv Drug Deliv Rev 54 (2002) 31-40
25. Teichamann A., Otberg N., Jacobi U., Sterry W., and Lademann J. Follicular penetration: development of a method to block the follicles selectively against the penetration of topically applied substances. Skin Pharmacol Physiol 19 (2006) 216-223
26. Ossadnik M., Czaika V., Teichmann A., Sterry W., Tietz H.J., Lademann J., et al. Differential stripping: introduction of a method to show the penetration of topically applied antifungal substances into the hair follicles. Mycoses 50 (2007) 457-462
27. Lademann J., Richter H., Schaefer U.F., Blume-Peytavi U., Teichmann A., Otberg N., et al. Hair follicles - a long-term reservoir for drug delivery. Skin Pharmacol Physiol 19 (2006) 232-236
28. Thielitz A., Helmdach M., Ropke E.M., and Gollnick H. Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents. Br J Dermatol 145 (2001) 19-27
29. Grams Y., Whitehead L., Cornwell P., and Bouwstra J. Time and depth resolved visualization of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin. J Control Release 98 (2004) 367-378
30. Lademann J., Otberg N., Richter H., Weigmann H.J., Lindemann U., Schaefer H., et al. Investigation of follicular penetration of topically applied substances. Skin Pharmacol Physiol 14 (2001) 17-22
31. Toll R., Jacobi U., Richter H., Lademann J., Schaefer H., and Blume-Peytavi U. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J Invest Dermatol 123 (2004) 168-176
32. Shim J., Kang H.S., Park W.S., Han S.H., Kim J., and Chang I.S. Transdermal delivery of minoxidil with block copolymer nanoparticles. J Control Release 97 (2004) 477-484
33. Grice J., Ciotti S., Weiner N., Lockwood P., Cross S., and Roberts M. Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci 99 (2010) 712-718
34. Ciotti S.N., and Weiner N. Follicular liposomal delivery systems. J Liposome Res 12 (2002) 143-148
35. Tabbakhian M., Tavakoli N., Jaafari M.R., and Daneshamouz S. Enhancement of follicular delivery of finasteride by liposomes and niosomes. 1. In vitro permeation and in vivo deposition studies using hamster flank and ear models. Int J Pharm 323 (2006) 1-10
36. Frum Y., Bonner M., Eccleston G., and Meidan V. The influence of drug partition coefficient on follicular penetration: in vitro human skin studies. Eur J Pharm Sci 30 (2007) 280-287
37. Munster U., Nakamura C., Haberland A., Jores K., Mehnert W., Rummel S., et al. RU 58841-myristate - prodrug development for topical treatment of acne and androgenetic alopecia. Pharmazie 60 (2005) 8-12
38. Hueber F., Wepierre J., and Schaefer H. Role of transepidermal and transfollicular routes in percutaneous absorption of hydrocortisone and testosterone: in vivo study in the hairless rat. Skin Pharmacol 5 (1992) 99-107
39. Teichmann A., Heuschkel S., Jacobi U., Presse G., Neubert R.H.H., Sterry W., et al. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in a o/w microemulsion and an amphiphilic cream. Eur J Pharm Biopharm 67 (2007) 699-706
40. Wu H., Ramachandran C., Weiner N.D., and Roessler B.J. Topical transport of hydrophilic compounds using water-in-oil nanoemulsions. Int J Pharm 63 (2001) 63-75
41. Weiner N. Targeted follicular delivery of macromolecules via liposomes. Int J Pharm 162 (1998) 29-38
42. Mitragotri S. Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways. J Control Release 86 (2003) 69-92
43. Lekki J., Stachura Z., Dabros W., Stachura J., Menzel F., Reinert T., et al. On the follicular pathway of percutaneous uptake of nanoparticles: ion microscopy and audioradiography studies. Nucl Instrum Methods Phys Res 260 (2007) 174-177
44. Zviak C., and Bouillon C. Hair treatment and hair care products. In: Zviak C. (Ed). The Science of Hair Care (1986), Marcel Dekker Inc, New York 87-148
45. Vogt A., Combadiere B., Hadam S., Stieler K.M., Lademann J., Schaefer H., et al. 40 nm, but not 750 or 1500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin. J Invest Dermatol 126 (2006) 1316-1322
46. Lademann J., Richter H., Teichmann A., Otberg N., Blume-Peytavi U., Luengo J., et al. Nanoparticles - an efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm 66 (2007) 159-164
47. Alvarez-Roman R., Naik A., Kalia Y.N., Guy R.H., and Fessi H. Skin penetration and distribution of polymeric nanoparticles. J Control Release 99 (2004) 53-62
48. Chen H., Chang X., Du D., Liu W., Weng T., Yang Y., et al. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J Control Release 110 (2006) 296-306
49. Lingna L., and Hoffman M. Topical liposome delivery of molecules to hair follicles in mice. J Dermatol Sci 14 (1997) 101-108
50. Jung S., Otberg N., Thiede G., Richter H., Sterry W., Panzner S., et al. Innovative liposomes as a transfollicular drug delivery system: penetration into porcine hair follicles. J Invest Dermatol 126 (2006) 1728-1732
51. Domashenko A., Gupta S., and Cotsarelis G. Efficient delivery of transgenes to human hair follicle progenitor cells using topical lipoplex. Nat Biotechnol 18 (2000) 420-423
52. Hoffman R.M. The hair follicles as a gene therapy target. Nat Biotechnol 18 (2000) 20-21
53. Li L., and Hoffman R.M. The feasibility of targeted selective gene therapy of the hair follicle. Nat Med 1 (1995) 705-706
54. Zhao M., Saito N., Li L., Baranov E., Kondoh H., Mishima Y., et al. A novel approach to gene therapy of albino hair in histoculture with a retroviral streptomyces tyrosinase gene. Pigment Cell Res 13 (2000) 345-351
55. Grams Y., Alaruikka S., Lashley L., Caussin J., Whitehead L., and Bouwstra J. Permeant lipophilicity and vehicle composition influence accumulation of dyes in hair follicles of human skin. Eur J Pharm Sci 18 (2003) 329-336
56. Ossadnik M., Richter H., Teichmann A., Koch S., Schafer U., Wepf R., et al. Investigation of differences in follicular penetration of particle- and nonparticle-containing emulsions by laser scanning microscopy. Laser Phys 16 (2006) 747-750
57. Illel B. Formulation for transfollicular drug administration: some recent advances. Crit Rev Ther Drug Carrier Syst 14 (1997) 207-219