Simultaneous determination of phillyrin and forsythiaside in Beagle Dog plasma by high-performance liquid chromatography with gradient elution and its application to pharmacokinetic studies

Analytical Letters

Volumn 43, Issue 2, 2010, Pages 209-218

  Yun Xia, Li ^a   Cheng, Peng ^a   Ruo Qi, Zhang ^b   Xue, Li ^b   Jiang, Xue Hua ^b  

^a CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Beagle dog; Forsythiaside; Gradient elution; HPLC; Pharmacokinetics; Phillyrin

Indexed keywords

CANIS FAMILIARIS;

EID: 74749088083     PISSN: 00032719     EISSN: 1532236X     Source Type: Journal    
DOI: 10.1080/00032710903325765     Document Type: Article

References (23)

1. Bing, Q., Q. X. H. Wei, and Y. T. Tang. 1999. Study on the anti-inflammatory and analgesia function of fructus forsythia extraction. Zhong Cao Yao 30: 43-45.
2. Chen, X., J. Zhang, C. Xue, X. Chen, and Z. Hu. 2004. Simultaneous determination of some active ingredients in anti-viral preparations of traditional Chinese medicine by micellar electrokinetic chromatography. Biomed. Chromatogr. 18: 673-80.
3. Díaz, L. A. M., M. M. J. Abad, M. L. Fernández, C. C. Recuero, C. L. Villaescusa, S. A. M. Silván,and B. P. Bermejo. 2001. Lignan and phenylpropanoid glycosides from phillyrea latifolia and their in vitro anti-inflammatory activity. Planta. Med. 67: 219-23.
4. Hu, J. K., F. J. Qu, K. X. Sun, and Y. H. Wang. 2004. Experiment study on the induction of a-interferon of human leucocyte in vitro by forsythiaside. J.Tradi. Chin. Med. 11: 355-56.
5. Hu, J. K., K. J. Xu, Y. H. Wang, K. X. Sun, and D. Wang. 2001. Study on the in vitro antiviral effect of forsythiaside. Chin. J. Tradi. Med. Sci. 8: 89-91.
6. Ishizuka, O., N. Kumazawa, S. Ohta, A. Kamogawa, and M. Shinoda. 1992. Effects of various methanol extracts of crude drugs on experimental subacute and chronic hepatic injury. Yakugaku Zasshi 112: 174-82.
7. Jin, H., J. F. Zuo, and J. S. Li. 2006. Study on the pharmacology of phenylethanoid glycosides. J. Shizhen Med. Mater. Res. 17: 440-44.
8. Kuang, H. X., N. Zhang, and Z. B. Lu. 1988. Antibacterial constituents of the unripe fruit of forsythia suspensa (Thunb.) Vahl. Zhong Yao Tong Bao. 13: 32-34, 62-63.
9. Kumazawa, N., S. Ohta, O. Ishizuka, N. Sakurai, A. Kamogawa, and M. Shinoda. 1990. Protective effects of various methanol extracts of crude drugs on experimental hepatic injury induced by carbon tetrachloride in rats. Yakugaku Zasshi. 110: 950-57.
10. Li, H. B., and F. Chen. 2005. Preparative isolation and purification of phillyrin from the medicinal plant forsythia suspensa by high-speed counter-current chromatography. J. Chromatogr. A 1083: 102-05.
11. Li, Y. X., X. H. Jiang, H. Y. Liang, and X. Li. 2008. Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Biomed. Chromatogr. 22: 361-66.
12. Li, Y. X., X. H. Jiang, L. Huang, J. Lu, and J. Zhou. 2006. Determination of phillyrin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. J. Pharm. Biomed. Anal. 41: 628-32.
13. Liu, J., and L. W. Hang. 2006. Functions of forsythiaside on the damage of DNA induced by hydroxyl radical. J. Shanxi. Med. Univ. 7: 23-24.
14. Liu, Y. J., Z. Q. Yang, H. Xiao, and L. Wen. 2004. Inhibitory effect of four kinds of extract of Chinese herbs - forsythia on herpes simplex virus type I. J. Hubei. Coll. Tradi. Chin. Med. 6: 36-37.
15. Sato, Y., N. Kumazawa, M. Suzuki, C. M. Wang, S. Ohta, and M. Shinoda. 1991. Studies on chemical protectors against radiation. XXXIII. Protective mechanisms of various compounds against skin injury induced by radiation. Yakugaku Zasshi 111: 51-58.
16. Schinella, G. R., H. A. Tournier, J. M. Prieto, P. Mordujovich de Buschiazzo, and J. L. Ríos. 2002. Antioxidant activity of anti-inflammatory plant extracts. Life Sci. 9: 1023-33.
17. Shi, Y., R. B. Shi, B. Liu, Y. R. Lu, and L. J. Du. 2003. Isolation and elucidation of chemical constituents with antiviral action from yinqiaosan on influenza virus. Zhongguo Zhong Yao Za Zhi. 28: 43-47.
18. Tamotsu, N., O. Taichi, and K. Takeshi. 1981. Inhibition of cyclic AMP phosphodiesterase by lignans. Chem. Pharm. Bull. 29: 3586-606.
19. Yang, T. M., Z. H. Zhang, and H. Zhang. 2003. Study on the anti-bacteria function of water extraction fructus forsythia. J. Lanzhou. Univ. (Med. Sci.). 9: 40-42.
20. Yoshida, T., N. Sakane, Y. Wakabayashi, T. Umekawa, and M. Kondo. 1995. Thermogenic anti-obesity effects of bofu-tsusho-san in MSG-obese mice. Int. J. Obes. Relat. Metab. Disord. 19: 717-22.
21. Zhang, L. W., C. G. Zhao, and P. Yang. 2003. Study on the antioxidant activity and structure-activity relationship of forsythiaside. Chin. Pharm. J. 38: 334-36.
22. Zhao, Y., F. Li, J. Yang, X. An, and M. Zhou. 2005. Effect of phillyrin on the anti-obesity in nutritive obesity mice. Zhong Yao Cai. 28: 123-24.
23. Zhao, Y. M., and F. R. Li. 2005. Study on the reducing blood lipid and antioxidition effects of phillyrin. Nat. Prod. Res. Dev. 17: 157-59.