Potential testicular toxicity of sodium nitrate in adult rats

Food and Chemical Toxicology

Volumn 48, Issue 2, 2010, Pages 572-578

  Aly, Hamdy A A ^a   Mansour, Ahmed M ^a   Abo Salem, Osama M ^a   Abd Ellah, Hala F ^b   Abdel Naim, Ashraf B ^c  

^a Cairo University   (Egypt)

^b University College of Girls for Arts   (Egypt)

^c Ain Shams University   (Egypt)

Author keywords

Oxidative stress; Sodium nitrate; Spermatogenesis; Testis

Indexed keywords

ACID PHOSPHATASE; CATALASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE ISOENZYME X; LIPID PEROXIDE; SODIUM NITRATE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHROMATOLYSIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL RAT; HISTOPATHOLOGY; MALE; NECROSIS; NONHUMAN; PYKNOSIS; RAT; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS FUNCTION; TESTIS INJURY; TESTIS WEIGHT;

ADMINISTRATION, ORAL; ANIMALS; CELL DEATH; ENZYME INHIBITORS; ENZYMES; GLUTATHIONE; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MALE; NITRATES; ORGAN SIZE; OXIDATIVE STRESS; OXIDOREDUCTASES; RATS; SPERM COUNT; SPERM MOTILITY; SPERMATOCYTES; SPERMATOZOA; TESTIS; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; RATTUS;

EID: 74649083668     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.11.034     Document Type: Article

References (63)

1. Abdel-Aziz A.H., Abdel-Naim A.B., Hamada F.M., and Ahmed A.E. In-vitro testicular bioactivation of acrylonitrile. Pharmacol. Res. 351 (1997) 129-134
2. Amann R.P. Sperm production rates. In: Johnson A.D., Gomes W.R., and Van Demark N.L. (Eds). The Testis (1970), Academic Press, New York 433-482
3. Amann R.P., Kavanaugh J.F., Griel L.C., and Voglmayr J.K. Sperm production of Holstein bulls determined from testicular spermatid reserves, after cannulation of rete testis or vas deferens, and by daily ejaculation. J. Dairy Sci. 57 (1974) 93-99
4. Amann R.P., Johnson L., Thompson D.L., and Pickett B.W. Daily spermatozoal production, epididymal spermatozoal reserves and transit time of spermatozoa through the epididymis of the rhesus monkey. Biol. Reprod. 15 (1976) 586-592
5. Anderson R.A., Willis B.R., Oswald C., and Zaneyeld L.J.D. Ethanol induced male infertility: impairment of spermatozoa. J. Pharmacol. Exp. Ther. 225 (1983) 479-486
6. Aschengrau A., Zierler S., and Cohen A. Quality of community drinking water and the occurrence of late adverse pregnancy outcomes. Arch. Environ. Health 48 (1993) 105-113
7. Atessahin A., Karahan I., Turk G., Gur S., Yilmaz S., and Ceribasi A.O. Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod. Toxicol. 21 (2006) 42-47
8. Banchroft J.D., Stevens A., and Turner D.R. Theory and practice of histological techniques. Fourth edition (1996), New York, Churchill Livingstone pp. 1-88
9. Bauché F., Fouchard M.H., and Jégou B. Antioxidant system in rat testicular cells. FEBS Lett. 349 (1994) 392-396
10. Bloomfield R.A., Welsch C.W., Garner G.B., and Muhrer M.E. Effect of dietary nitrate on thyroid function. Science 134 (1961) 1690
11. Bogovski P., and Bogovski S. Animal species in which N-nitroso compounds induce cancer. Int. J. Cancer 27 (1981) 471-474
12. Bruning-Fann C.S., and Kaneene J.B. The effects of nitrate, nitrite and N-nitroso compounds on human health: a review. Vet. Hum. Toxicol. 35 (1993) 521-538
13. Buege J.A., and Aust S.D. Lactoperoxidase catalyzed lipid peroxidation of microsomal and artificial membranes. Biochem. Biophys. Acta 444 (1976) 192-201
14. Bukowski J., Somers G., and Bryanton J. Agricultural contamination of groundwater as a possible risk factor for growth restriction or prematurity. J. Occup. Environ. Med. 43 (2001) 377-383
15. Carlberg I., and Mannervik B. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J. Biol. Chem. 250 (1975) 5474-5480
16. Cedergren M.I., Selbing A.J., Lofman O., and Kallen B.A.J. Chlorination byproducts and nitrate in drinking water and risk for congenital cardiac defects. Environ. Res. 891 (2002) 24-130
17. Chapin R.E., Dutton S.L., Ross I.V., and Lamb J.C. The recovery of the testis over weeks after short term dosing with ethylene glycol monomethyl ether: histology, cell specific enzymes, and rate testis fluid protein. Fundam. Appl. Toxicol. 5 (1985) 515-525
18. Chapin R.E., Harris M.W., Davis B.J., Ward S.M., Wilson R.E., Mauney M.A., Lockhart A.C., Smialowicz R.J., Moser V.C., Burka L.T., and Collins B.J. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam. Appl. Toxicol. 40 (1997) 138-157
19. Cheever K.L., Weigel W.W., Rechards D.E., Lal J.B., and Plotnick H.B. Testicular effect of bis (2-methoxyethyl) ether in the adult male rat. Toxicol. Ind. Health 5 (1989) 1099-10109
20. Claiborne A. Catalase. In: Geenwald R. (Ed). Handbook of Oxygen Research Radical Research (1985), New York, CRC Press. 283-284
21. Colomina M.T., Llobet J.M., Sirvent J.J., Domingo J.L., and Corbella J. Evaluation of the reproductive toxicity of gallium nitrate in mice. Food Chem. Toxicol. 31 (1993) 847-851
22. Croen L.A., Todoroff K., and Shaw G.M. Maternal exposure to nitrate from drinking water and diet and risk for neural tube defects. Am. J. Epidemiol. 153 (2001) 325-331
23. Denisenko S.V., and Kostenko V.A. Changes of mitochondrial oxidation and phosphorylation in the testes of white rats under excessive supply of sodium nitrate into the organism. Ukr. Biokhim. Zh. 75 (2003) 101-103
24. El-Sokkary G., Reither J.R., Tan D.X., Kim S.J., and Cabrera J. Inhibitory effect of melatonin on products of lipid peroxidation resulting from chronic ethanol administration. Alcohol Alcohol. 34 (1999) 842-850
25. Ericson A., Kallen B., and Lofkvist E. Environmental factors in the etiology of neural tube defects: a negative study. Environ. Res. 45 (1988) 38-47
26. European Environment Agency. Europe's Environment: The Third Assessment. Environmental Assessment Report No. 10 (2003), Copenhagen, European Environment Agency
27. Foster P.M.D., Sheard C.C., and Lloyd S.C. 1, 3 Dinitrobenzene: a sertoli cell toxicant. Int. Congr. Ser. - Excerpta Med. 718 (1986) 281-288
28. Gatseva P.D., Mardirosian Z.H., Popova E.J., Iskrenova E.S., Vladeva S.V., and Pavlova K.I. Evaluation of health hazards in children from regions with nitrate pollution. Folia Med. (Plovdiv) 42 (2000) 19-22
29. Griveau F., and Le Lannou D. Reactive oxygen species and human spermatozoa: physiology and pathology. Int. J. Androl. 20 (1997) 61-69
30. Gupta S.K., Gupta R.C., Gupta A.B., Seth A.K., Bassin J.K., and Gupta A. Recurrent acute respiratory infections in areas with high nitrate concentrations in drinking water. Environ. Health Perspect. 108 (2000) 363-366
31. Ho H.Y., Cheng M.L., and Chiu D.T. Glucose-6-phosphate dehydrogenase-from oxidative stress to cellular functions and degenerative diseases. Redox Rep. 12 (2007) 109-118
32. Hodgen G.D., and Sherins R.J. Enzymes as markers of testicular growth and development in the rat. Endocrinology 93 (1973) 985-989
33. Hutson S.S., Barber N.L., Kenny J.F., Linsey K.S., Lumia D.S., and Maupin M.A. Estimated Use of Water in the United States in 2000. USGS Circular 1268 (2004), U.S. Geological Survey, Denver, CO
34. Jaji M.O., Bamgbose O., Odukoya O.O., and Arowolo T.A. Water quality assessment of Ogun river, South West Nigeria. Environ. Monit. Assess. 133 (2007) 473-482
35. Kaur F., Sangha G.K., and Bilaspuri G.S. Cyclophosphamide-induced structural and biochemical changes in testis and epididymidis of rats. Indian J. Exp. Biol. 35 (1997) 771-775
36. Kurus M., Esrefoglu M., Sogutlu G., and Atasever A. Melatonin prevents cyclosporine-induced hepatotoxicity in rats. Med. Princ. Pract. 18 (2009) 407-410
37. Levallois P., Thériault M., Rouffignat J., Tessier S., Landry R., Ayotte P., Girard M., Gingras S., Gauvin D., and Chiasson C. Groundwater contamination by nitrates associated with intensive potato culture in Québec. Sci. Total Environ. 217 (1998) 91-101
38. Lowry O.H., Rosenbrough N.J., Farr A.I., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
39. Manassaram D.M., Backer L.C., and Moll D.M. A review of nitrates in drinking water: maternal exposure and adverse reproductive and developmental outcomes. Cien. Saude Colet. 12 (2007) 153-163
40. Marklund S.L. Superoxide dismutase isoenzymes in tissues and plasma from New Zealand Black mice. Mutat. Res. 148 (1985) 129-134
41. Meistrich M.L. Quantitative correlation between testicular stem cell survival, sperm production, and fertility in the mouse after treatment with different cytotoxic agents. J. Androl. 3 (1982) 58-68
42. Mori K., Kaido M., Fujishiro K., Inoue N., Ide Y., and Koide O. Preventive effects of methylcobalamin on the testicular damage induced by ethylene oxide. Arch. Toxicol. 65 (1991) 396-401
43. Mori K., Kaido M., Fujishiro K., Inoue N., and Koide O. Effects of megadoses of pyridoxine on spermatogenesis and male reproductive organs in rats. Arch. Toxicol. 66 (1992) 198-203
44. Paglia D.E., and Valentine W.N. Studies on quqntitqtive and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70 (1967) 158-169
45. Pant N., and Srivastava S.P. Testicular and spermatotoxic effect of nitrate in mice. Hum. Exp. Toxicol. 21 (2002) 37-41
46. 2 production by chemically elicited peritoneal macrophages-induction by multiple nonphagocytic stimuli. Cell. Immunol. 59 (1981) 301-318
47. Pomeranz A., Korzets Z., Vanunu D., and Krystal H. Elevated salt and nitrate levels in drinking water cause an increase of blood pressure in schoolchildren. Kidney Blood Press. Res. 23 (2000) 400-403
48. Roux J.C. The evolution of ground water quality in France: Perspectives for enduring use for human consumption. Sci. Total Environ. 171 (1995) 3-16
49. Sedlak J., and Lindsay R.H. Estimation of total protein sulhydryl groups in tissues With Ellman, s reagent. Anal. Biochem. 25 (1968) 192-205
50. Selvakumar E., Prahalathan C., Mythili Y., and Varalakshmi P. Beneficial effects of DL-α- lipoic acid on cyclophosphamide-induced oxidative stress in mitochondrial fractions of rat testis. Chem.-Biol. Interact. 152 (2005) 59-66
51. Selvakumar E., Prahalathan C., Sudharsan P.T., and Varalakshmi P. Protective effect of lipoic acid on cyclophosphamide-induced testicular toxicity. Clin. Chim. Acta 367 (2006) 114-119
52. Shen R.S., and Lee I.P. Selected testicular enzymes as biochemical markers for procarbazine-induced testicular toxicity. Arch. Toxicol. 55 (1984) 233-238
53. Spalding R.F., and Exner M.E. Occurrence of nitrate in ground-water-a review. J. Environ. Qual. 22 (1993) 392-402
54. Super M., Heese H.D.V., MacKenzie D., Dempster W.S., Du Plessis J., and Ferreira J.J. An epidemiological study of well-water nitrates in a group of South West African/Namibian infants. Water Res. 15 (1981) 1265-1270
55. USGS. Nitrate in Ground Waters of the US-Assessing the Risk. FS-092-96. Reston, VA: U.S. Geological Survey; 1996.
56. van Maanen J.M., Albering H.J., de Kok T.M., van Breda S.G., Curfs D.M., Vermeer I.T., Ambergen A.W., Wolffenbuttel B.H., Kleinjans J.C., and Reeser H.M. Does the risk of childhood diabetes mellitus require revision of the guideline values for nitrate in drinking water?. Environ. Health Perspect. 108 (2000) 457-461
57. Verma P.K., Singh J.N., and Quadros M. LDH-X in azospermia: a new diagnostic alternative to vasography and testicular biopsy. Indian J. Med. Sci. 97 (1993) 204-207
58. Wagner H.J., and Schülke B. Microsomal glucose-6-phosphate dehydrogenase in the rat testis-an testis-specific isoenzyme?. Biomed. Biochim. Acta. 43 (1984) 3-9
59. Ward M.H., deKok T.M., Levallois P., Brender J., Gulis G., Nolan B.T., and VanDerslice J. International Society for Environmental Epidemiology. Workgroup report: Drinking water nitrate and health-recent findings and research needs. Environ. Health Perspect. 113 (2005) 1607-1614
60. Weyer P.J., Cerhan J.R., Kross B.C., Hallberg G.R., Kantamneni J., Breuer G., Jones M.P., Zheng W., and Lynch C.F. Municipal drinking water nitrate level and cancer risk in older women: the Iowa women's health study. Epidemiology 12 (2001) 327-338
61. WHO. Health hazards from nitrates in drinking water (1985), World health organization, Copenhagen
62. WHO 2003. Nickel in drinking water. Background document for preparation of WHO Guidelines for drinking water quality. Geneva, World Health Organization (WHO/SDE/WSH/03.04/55).
63. WHO 2004. Guidelines for Drinking Water Quality, third ed. Vol. 1, Recommendations. Geneva, World Health Organization.