Optimal response to thalidomide in a patient with thalassaemia major resistant to conventional therapy

Blood Transfusion

Volumn 8, Issue 1, 2010, Pages 63-65

  Masera, Nicoletta ^a   Tavecchia, Luisa ^a   Capra, Marietta ^a   Cazzaniga, Giovanni ^a   Vimercati, Chiara ^a   Pozzi, Lorena ^a   Biondi, Andrea ^a   Masera, Giuseppe ^a  

^a SAN GERARDO HOSPITAL   (Italy)

Author keywords

Haemoglobin F; Thalassaemia; Thalidomide

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FOLIC ACID; HEMOGLOBIN; HYDROXYUREA; RITUXIMAB; THALIDOMIDE;

ADULT; ANEMIA; ARTICLE; CASE REPORT; CONGESTIVE CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; DRUG MEGADOSE; DRUG RESPONSE; DRUG WITHDRAWAL; ERYTHROBLASTOSIS; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOLYSIS; HUMAN; LIVER FUNCTION; MULTIPLE CYCLE TREATMENT; OSTEOPOROSIS; SPLENECTOMY; THALASSEMIA MAJOR; TREATMENT RESPONSE;

ADULT; BETA-THALASSEMIA; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; THALIDOMIDE;

EID: 74549203895     PISSN: 17232007     EISSN: None     Source Type: Journal    
DOI: 10.2450/2009.0102-09     Document Type: Article

References (12)

1. Wood WG, Weatherall DJ, Clegg JB. Interaction of heterocellular hereditary persistence of foetal haemoglobin with beta thalassaemia and sickle cell anaemia. Nature 1976; 264: 247-9.
2. Charache S, Terrin ML, Moore RD, et al. Effect of hydroxyurea on frequency of painful crises in sickle cell anaemia. N Engl J Med 1995; 332: 1317-22.
3. Platt OS, Orkin SH, Dover G, et al. Hydroxyurea enhances fetal haemoglobin production in sickle cell anemia. J Clin Invest 1984; 74: 652-6.
4. Fucharoen S, Siritanaratkul N, Winichagoon P, et al. Hydroxyurea increases haemoglobin F levels and improves the effectiveness of erythropoiesis in beta thalassemia haemoglobin E disease. Blood 1996; 87: 887-92.
5. Hajjar FM, Pearson HA. Pharmacologic treatment of thalassemia intermedia with hydroxyurea. J Pediatr 1994; 125: 490.
6. Candido EP, Reeves R, Davie JR. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 1978; 14: 105-13.
7. Ley TG, De Simone J, Anagnou NP, et al. 5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N Engl J Med 1982; 307: 1469.
8. De Simone J, Koshy M, Dorn L, et al. Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia. Blood 2002; 99: 3905-8.
9. Aerbajinai W, Zhu J, Gao Z, et al. Thalidomide induces γ-globin gene expression through increased reactive oxygen species-mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis. Blood 2007; 110: 2864-71.
10. Moutouh-de Parseval LA, Verhelle D, Glezer E et al. Pomalidomide and lenalidomide regulate erythropoiesis and fetal haemoglobin production in human CD34+ cells. J Clin Invest 2008; 118: 248-58.
11. Aguilar-Lopez LB, Delgado Lamas JL, Rubio-Jurado B, et al. Thalidomide therapy in a patient with thalassemia major. Blood Cells Mol Dis 2008; 41: 136-7.
12. Trompeter S, Roberts I. Haemoglobin F modulation in childhood sickle cell disease. Br J Haematol 2008; 144: 308-16.