Investigation of the anti-inflammatory and antinociceptive activities of Elephantorrhiza elephantina (Burch.) Skeels root extract in male rats

African Journal of Biotechnology

Volumn 8, Issue 24, 2009, Pages 7068-7072

  Maphosa, V ^a   Masika, P J ^a   Moyo, B ^a  

^a UNIVERSITY OF FORT HARE   (South Africa)

Author keywords

Acute toxicity; Aqueous extract; Inflammation; Pain

Indexed keywords

ACETIC ACID; ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; CARRAGEENAN; ELEPHANTORRHIZA ELEPHANTINA EXTRACT; FORMALDEHYDE; HISTAMINE; INDOMETACIN; PLANT EXTRACT; POLYSORBATE 80; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; ELEPHANTORRHIZA ELEPHANTINA; MALE; MEDICINAL PLANT; NONHUMAN; PAIN; PAW EDEMA; PLANT ROOT; RAT; WRITHING TEST;

ELEPHANTORRHIZA ELEPHANTINA; FABACEAE; RATTUS; RATTUS NORVEGICUS;

EID: 74549199834     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Adedapo AA, Sofidiya MO, Maphosa V, Moyo B, Masika P, Afolayan AJ (2008). Anti-inflammatory and analgesic activities of the aqueous extract of Cussonia paniculata stem Bark. A C G publications, 2: 46-53.
2. Ahmadiani A, Fereidoni M, Semnanian S, Kamalinejadand M, Saremi S, (1998) Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats. J. Ethnopharmacol. 61: 229-235.
3. Barros IMC, Lopes LDG, Borges MOR, Borges ACR, Ribeiro MNS, Freire SMF (2006). Anti-inflammatory and anti-nociceptive activities of Pluchea quitic (D.C) ethanolic extract. J. Ethnopharmacol. 106: 317-320.
4. Dold AP, Cocks ML (2001).Traditional veterinary medicine in the Alice district of the Eastern Cape Province South Africa. S. Afr. J. Sci. 97: 1-5.
5. Gunakunru A, Padmanaban K, Thirumal P, Vengatesan N, Gnansekar N, Raja S, Rajarajan AT, Vijay Kumar SG, Periyanayagan JB (2004). Chemical investigations and anti-inflammatory activity of fixed oil of Butea monosperma seeds. Nat. Prod. Sci. 10: 55-58.
6. Gupta M, Mazunder UK, Sambath Kumbar R, Gomath P, Rajeshwar Y, Kakoti BB, Tamil SV (2005). Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhina racemosa stem bark in animal models. J. Ethnopharmacol. 98: 267-273.
7. Hilaly JE, Israili ZH, Lyoussi (2004). B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. J. Ethnopharmacol. 91: 43-30.
8. Hunskaar S, Famer OB, Hole K (1985). Formalin test in mice: a useful technique for evaluating wild analgesics. J. Neuroscie Meth. 14: 69-76.
9. Hutchings A, Scott AH, Lewis G (1996). Zulu medicinal plants: An inventory, Natal, South Africa: University of Natal Press. pp. 266-267.
10. Luseba D, Van der Merwe D (2006). Ethnoveterinary medicine practices among Tsonga speaking people of South Africa. Onderstepoort J. Vet. Res. 73: 115-122.
11. McGaw LJ, Eloff JN (2008). Ethnoveterinary use of southern African plants and scientific evaluation of their medicinal properties. J. Ethnopharmacol. 10: p. 1016.
12. Naidoo V (2005). Screening of four plants commonly used in ethnoveterinary medicine for antimicrobial, anti-protozoal and anti-oxidant activity. MSc dissertation. University of Pretoria. pp. 1-130.
13. Parmar NS, Ghosh MMN (1978). Current trends in flavonoid research. Indian J. Pharm. 12: 213-228.
14. Perianayagam JB, Sharma SK, Pillai KK (2006). Anti-inflammatory activity of Trichodesma indicum root extract in experimental animals. J. Ethnopharmacol. 104: 410-414.
15. Spereni E, Cervellati R, Innocenti G, Costa S, Guerra MC, Dall' Acqua S, Govoni P (2005). Anti-inflammatory, anti-nociceptive and antioxidant activities of Balanites aegyptica (L) Delile. J. Ethnopharmacol. 98: 117-125.
16. Tjolsen A, Berge O, Hunskaar S, Roseland JK, Hole K (1992). The formalin test: an evaluation of the method. Pain, 51: 5-17.
17. Van Wyk BE, Van Oudtshoorn B, Gericke N (1997). Medicinal Plants of South Africa. Pretoria: Brizza Publications, p. 304.
18. Vesudevan M, Gunman KK, Parle M (2007). Antinociceptive and antiinflammatory effects of Thespesia populnea bark extract. J. Ethnopharmacol. 109: 264-270.
19. Zakaria MNM, Zathakrishnan R, Chen HB, Kamil M, Al-gisri AN, Chan K, Al-attas A (2001). Antinociceptive and anti-inflammatory properties of Carraluma arabica. J. Ethnopharmacol. 76: 155-158.