Evaluation of gastrointestinal motility in awake rats: A learning exercise For undergraduate biomedical students

American Journal of Physiology - Advances in Physiology Education

Volumn 33, Issue 4, 2009, Pages 343-348

  Souza, M A N ^a   Souza, M H L P ^a   Palheta, Jr ^a   Cruz, P R M ^a   Medeiros, B A ^a   Rola, F H ^a   Magalhaes P J C ^a   Troncon, L E A ^b   Santos, A A ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Duodenal brake; Insulinic hypoglycemia; Laboratory syllabus

Indexed keywords

EID: 74549196894     PISSN: 10434046     EISSN: 15221229     Source Type: Journal    
DOI: 10.1152/advan.90176.2008     Document Type: Article

References (33)

1. Bachrach WH. Action of insulin hypoglycemia on motor and secretory functions of the digestive tract. Physiol Rev 33: 566-592, 1953.
2. Bateman DN, Whittingham TA. Measurement of gastric emptying by real-time ultrasound. Gut 23: 524-527, 1982.
3. Beraldo WT, Alvarenga GP. O ensino não diretivo em Fisiologia. Rev Univ Fed Minas Gerais Suppl 16: 113-128, 1966.
4. Davenport HW. The life and death of laboratory teaching of medical physiology: a personal narrative. Part I. Adv Physiol Educ 10: 16-23, 1993.
5. Davenport HW. The life and death of laboratory teaching of medical physiology: a personal narrative. Part II. Adv Physiol Educ 10: 55-71, 1993.
6. Firth M, Prather CM. Gastrointestinal motility problems in the elderly patient. Gastroenterology 122: 1688-1700, 2002.
7. Fraser RJ, Horowitz M, Dent J. Hyperglycemia stimulates pyloric motility in normal subjects. Gut 32: 475-478, 1990.
8. Friedman MI, Ramirez I, Wade GN, Siegel LI, Granneaman J. Metabolic and physiologic effects of a hunger-inducing injection of insulin. Physiol Behav 29: 515-518, 1982.
9. George JD. New clinical method for measuring the rate of gastric emptying: the double sampling test meal. Gut 9: 237-242, 1968.
10. Ghoos Y, Maes B, Geypens B, Mys G, Hiele M, Rutgeerts P, Vantrappen G. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 104: 1640- 1647, 1993.
11. de Gondim AA F, de-Oliveira GR, Graça JR, Cavalcante DI, Souza MA, Santos AA, Rola FH. Gastric emptying of liquid after acute blood volume changes. Braz J Med Biol Res 31: 967-973, 1998.
12. Griffith GH, Owen GM, Kirkman S, Shields R. Measurement of rate of gastric emptying using chromium-51. Lancet 1: 1244-1245, 1966.
13. Heading RC, Tothill P, McLoughlin GP, Shearman DJ. Gastric emptying rate measurement in man. A double isotope scanning technique for simultaneous study of liquid and solid components of a meal. Gastroenterology 71: 45-50, 1976.
14. Hunt JN, Spurrell WR. The pattern of emptying of the human stomach. J Physiol 113: 157-168, 1951.
15. Hunt RH, Tougas G. Evolving concepts in functional gastrointestinal disorders: promising directions for novel pharmaceutical treatments. Best Pract Res Clin Gastroenterol 16: 869-883, 2002.
16. Kirsner JB. The origin of 20th century discoveries transforming clinical gastroenterology. Am J Gastroenterol 93: 862-871, 1998.
17. Lane A, Geadah D, Laferriere M, Lebrun M, Caron D, Ross P. Performance of the new plasma-compatible Advantage blood glucose test strips. Clin Biochem 30: 465-468, 1997.
18. MacCann MJ, Stricker EM. Gastric emptying of glucose loads in rats: effects of insulin-induced hypoglycemia. Am J Physiol Regul Integr Comp Physiol 251: R609-R613, 1986.
19. Maerz LL, Sankaran H, Scharpf SJ, Deveney CW. Effect of caloric content and composition of a liquid meal on gastric emptying in the rat. Am J Physiol Regul Integr Comp Physiol 267: R1163-R1167, 1994.
20. Malagelada JR, Azpiroz F. Determinants of gastric emptying and transit in the small intestine. In: Handbook of Physiology. The Gastrointestinal System. Motility and Circulation. Bethesda, MD: Am. Physiol. Soc., 1989, sect. 6, vol. I, pt. 2, chapt. 23, p. 909-938.
21. Oliveira RB, Troncon LE, Meneghelli UG, Dantas RO, Godoy RA. Gastric accommodation to distension and early gastric emptying in diabetics with neuropathy. Braz J Med Biol Res 17: 49-53, 1984.
22. Ra'anan AW. The evolving role of animal laboratories in physiology instruction. Adv Physiol Educ 29: 144-150, 2005.
23. Reynell PC, Spray GH. The simultaneous measurement of absorption and transit in the gastrointestinal tract of the rat. J Physiol 131: 452-462, 1956.
24. Schvarcz E, Palmer M, Aman J, Lindkvist B, Beckman KW. Hypoglycaemia increases the gastric emptying rate in patients with type 1 diabetes mellitus. Diabet Med 10: 660-3, 1993.
25. Schvarcz E, Palmer M, Aman J, Berne C. Hypoglycemia increases the gastric emptying rate in healthy subjects. Diabetes Care 18: 674-6, 1995.
26. Schvarcz E, Palmer M, Aman J, Horowitz M, Stridsberg M, Berne C. Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 113: 60-66, 1997.
27. Szurszewski JH. A 100-year perspective on gastrointestinal motility. Am J Physiol Gastrointest Liver Physiol 274: G447-G453, 1998.
28. Troncon LEA, Bennett RJ, Ahluwalia NK, Thompson DG. Abnormal intra-gastric distribution of food during gastric emptying in functional dyspepsia patients. Gut 35: 327-332, 1994.
29. Troncon LEA, Santos AA, Garbacio VL, Secaf M, Verceze AV, Cunha-Melo JR. Inhibition of gastric emptying and intestinal transit in anesthetized rats by a Tityus serrulatus scorpion toxin. Brazil J Med Biol Res 33: 1053-1058, 2000.
30. Thompson WG. Prevalence of gastrointestinal symptoms In: Evidence-Based Gastroenterology, edited by Irvine EJ, Hunt RH. London: BC Decker, 2001, chapt. 2, p. 8-18.
31. Wan CK, Giacca A, Matsuhisa M, El-Bahrani B, Lam L, Rodgers C, Shi ZQ. Increased responses of glucagon and glucose production to hypoglycemia with intraperitoneal versus subcutaneous insulin treatment. Metabolism 49: 984-989, 2000.
32. Wingate DL. Backwards and forwards with the migrating complex. Dig Dis Sci 26: 641-666, 1981.
33. Yuan PQ, Yang H. Neuronal activation of brain vagal-regulatory pathways and upper gut enteric plexuses by insulin hypoglycemia. Am J Physiol Endocrinol Metab 283: E436-E448, 2002.