Preoperative Heparin Therapy Causes Immune-Mediated Hypotension Upon Heparin Administration for Cardiac Surgery

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 24, Issue 1, 2010, Pages 69-72

  Casthely, Pierre A ^a   Defilippi, Vincent ^a   Cornwell, Lorraine ^a   Samuel, Zachary ^a   Yoganathan, Thil ^a   Komer, Claudia ^b   Cisbarros, Suzanne ^a   Acevedo, Alizabeth ^a  

^a ST JOSEPH S REGIONAL MEDICAL CENTER   (United States)

^b ST MICHAEL S MEDICAL CENTER   (United States)

Author keywords

cardiopulmonary bypass; cardiovascular changes; full heparinization; heparin antibodies; histamine levels; low dose heparin; thrombocytopenia

Indexed keywords

ANTIBODY; HEPARIN; HISTAMINE;

ADULT; AGED; ARTICLE; BLOOD CLOTTING TIME; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CONTINUOUS INFUSION; FEMALE; HEART INDEX; HEART SURGERY; HEART VENTRICLE FUNCTION; HEPARINIZATION; HUMAN; HYPOTENSION; IMMUNE MEDIATED HYPOTENSION; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADULT; AGED; ANTIBODIES; ANTICOAGULANTS; CORONARY ARTERY BYPASS; FEMALE; HEMODYNAMICS; HEPARIN; HISTAMINE; HUMANS; HYPOTENSION; MALE; MIDDLE AGED; PLATELET COUNT; PREOPERATIVE CARE; PROSPECTIVE STUDIES; THROMBOCYTOPENIA; WHOLE BLOOD COAGULATION TIME;

EID: 74549194565     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2009.10.015     Document Type: Article

References (22)

1. Green D., Harris K., Reynolds N., et al. Heparin immune thrombocytopenia: Evidence for a heparin-platelet complex as the antigenic determinant. J Lab Clin Med 91 (1978) 167-175
2. Ansell J., Slepchuk N., Kumar R., et al. Heparin induced thrombocytopenia: A prospective study. Thromb Hemost 43 (1980) 61-65
3. Wolf H., Nowack H., and Wick G. Detection of antibodies interacting with glycosaminoglycan polysulfate in patients treated with heparin or other polysulfated glycosaminoglycans. Int Arch Allergy Appl Immunol 70 (1983) 157-163
4. Casthely P.A., and Yoganathan T. Histamine blockade and cardiovascular changes following heparin administration during cardiac surgery. J Cardiothoracic Anesth 4 (1990) 711-714
5. Verburg K.M., Bowsher R.R., and Henry D.R. A new radioenzymatic assay for histamine using purified histamine N-methyltransferase. Life Sci 5 (1983) 28-67
6. Yin E.T., Wessler S., and Butler J.V. Plasma heparin: A unique practical submicrogram sensitive assay. J Lab Clin Med 81 (1973) 298-310
7. Warketin T.E., Levine M.N., Hirsh J., et al. Heparin induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 332 (1995) 1330-1335
8. Catinella F.P., Cunningham J.N., and Strauss E.D. Variations in total and ionized calcium during cardiac surgery. J Thorac Cardiovasc Surg 91 (1986) 303-306
9. Muller-Eberhard J.H. Complement. Ann Rev Biochem 44 (1975) 697
10. Goad K.E., Horne M.K., and Gralnick H.R. Pentosan-induced thrombocytopenia: Support for an immune complex mechanism. Br J Haematol 88 (1994) 803-808
11. Greinacher A., Michels I., and Mueller-Eckhardt C. Heparin associated thrombocytopenia: The antibody is not heparin specific. Thromb Haemost 67 (1992) 547-549
12. Greinacher A., Michels I., Schafer M., et al. Heparin associated thrombocytopenia in a patient treated with polysulfated chondroitin sulfate: Evidence for immunological cross reaction between heparin and polysulfated glycosaminoglycans. Br J Haematol 81 (1992) 252-254
13. 1, antiaggregating effect in human platelet. J Lab Clin Med 93 (1979) 638-644
14. Trowbridge A.A., Careveo J., Green J.B., et al. Heparin-related immunothrombocytopenia. Studies of antibody-heparin specificity. Am J Med 65 (1978) 277-283
15. 5CA anaphylatoxins. N Engl J Med 304 (1981) 497-503
16. Johnson R.A., Lazarus K.H., and Henry D.H. Heparin-induced thrombocytopenia: A prospective study. Am J Hematol 17 (1984) 349-353
17. Green D., Martin G.J., Shoichet S.H., et al. Thrombocytopenia in a prospective, randomized, double-blind trial of bovine and porcine heparin. Am J Med Sci 288 (1984) 60-64
18. Bauer T.L., Arepally G., Konkle B.A., et al. Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation 95 (1997) 1242-1246
19. Amiral J., Bridey F., Dreyfus M., et al. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 68 (1992) 95-96
20. Salzman E.Q., Rozenberg R.D., Smith M.H., et al. Effect of heparin and heparin fractions on platelet aggregation. J Clin Invest 65 (1980) 64-73
21. Chong B.H., and Castaldi P.A. Heparin-induced thrombocytopenia: Further studies of the effects of heparin-dependent antibodies on platelets. Br J Haematol 64 (1986) 347-354
22. Bell W.R., and Royall R.M. Heparin associated thrombocytopenia: A comparison of three heparin preparations. N Engl J Med 303 (1980) 902-907