Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins

BMC Microbiology

Volumn 9, Issue , 2009, Pages

  Jones, Adam C ^a   Gerwick, Lena ^a   Gonzalez, David ^b   Dorrestein, Pieter C ^b,c   Gerwick, William H ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

JAMAICAMIDE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; 2 PYRROLIDONE DERIVATIVE; AMIDE; BACTERIAL PROTEIN; BACTERIAL RNA; JAMAICAMIDE A; LIPOPEPTIDE; SPACER DNA; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; DNA PROBE; GENE CLUSTER; LIQUID CHROMATOGRAPHY; LYNGBYA MAJUSCULA; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; START CODON; TANDEM MASS SPECTROMETRY; TRANSCRIPTION INITIATION SITE; BIOSYNTHESIS; CYANOBACTERIUM; DNA SEQUENCE; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; REPORTER GENE;

CYANOBACTERIA; LYNGBYA; LYNGBYA MAJUSCULA;

AMIDES; BACTERIAL PROTEINS; BASE SEQUENCE; CYANOBACTERIA; DNA, INTERGENIC; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REPORTER; LIPOPEPTIDES; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PROMOTER REGIONS, GENETIC; PYRROLIDINONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, BACTERIAL; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

EID: 74549175968     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-9-247     Document Type: Article

References (53)

1. Marine natural products. JW Blunt BR Copp W-P Hu MHG Munro PT Northcote MR Prinsep, Nat Prod Rep 2008 25 35 94 10.1039/b701534h 18250897
2. Bioactive natural products from marine cyanobacteria for drug discovery. LT Tan, Phytochem 2007 68 954 979 10.1016/j.phytochem.2007.01.012 (Pubitemid 46413338)
3. The natural products chemistry of cyanobacteria. K Tidgewell BR Clark WH Gerwick, Comprehensive Natural Products Chemistry Pergamon Press
4. The barbamide biosynthetic gene cluster: A novel cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Z Chang P Flatt WH Gerwick V-A Nguyen CL Willis DH Sherman, Gene 2002 296 235 247 10.1016/S0378-1119(02) 00860-0 12383521
5. Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. Z Chang N Sitachitta JV Rossi MA Roberts PM Flatt J Jia DH Sherman WH Gerwick, J Nat Prod 2004 67 1356 1367 10.1021/np0499261 15332855
6. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. DJ Edwards BL Marquez LM Nogle K McPhail DE Goeger MA Roberts WH Gerwick, Chem Biol 2004 11 817 833 10.1016/j.chembiol.2004.03.030 15217615
7. GNAT-like strategy for polyketide chain initiation. L Gu TW Geders B Wang WH Gerwick K Håkansson JL Smith DH Sherman, Science 2007 318 970 974 10.1126/science.1148790 17991863
8. Natural products in drug discovery and development: The United States National Cancer Institute Role. GM Cragg DJ Newman KM Snader, Phytochemicals in Human Health Protection, Nutrition, and Plant Defense New York: Kluwer Academic/Plenum Publishers, Romeo JT, 1999 1 29
9. Stereospecific total synthesis of somocystinamide A. TL Suyama WH Gerwick, Org Lett 2008 10 4449 4452 10.1021/ol8016947 18788741
10. Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. BA Pfeifer CCC Wang CT Walsh C Khosla, Appl Environ Microbiol 2003 69 6698 6702 10.1128/AEM.69.11.6698- 6702.2003 14602630
11. Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. EW Schmidt JT Nelson DA Rasko S Sudek JA Eisen MG Haygood J Ravel, Proc Natl Acad Sci USA 2005 102 7315 7320 10.1073/pnas.0501424102 15883371
12. Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. K Watanabe K Hotta AP Praseuth K Koketsu A Migita CN Boddy CCC Wang H Oguri H Oikawa, Nat Chem Biol 2006 2 423 428 10.1038/nchembio803 16799553
13. Mining and engineering natural-product biosynthetic pathways. B Wilkinson J Micklefield, Nat Chem Biol 2007 3 379 386 10.1038/nchembio.2007.7 17576425
14. Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. U Galm B Shen, Exp Op Drug Discov 2006 1 409 437 10.1517/17460441.1.5.409
15. Pilot scale culture of the marine cyanobacterium Lyngbya majuscula for its pharmaceutically-useful natural metabolite curacin A. JV Rossi MA Roberts H-D Yoo WH Gerwick, J Appl Phycol 1997 9 195 204 10.1023/A:1007973009869 (Pubitemid 27474151)
16. Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. M Ishiura S Kutsuna S Aoki H Iwasaki CR Andersson A Tanabe SS Golden CH Johnson T Kondo, Science 1998 281 1519 1523 10.1126/science.281.5382. 1519 9727980
17. PatS and products of nitrogen fixation control heterocyst pattern. H-S Yoon JW Golden, J Bacteriol 2001 183 2605 2613 10.1128/JB.183.8.2605-2613.2001 11274121
18. Regulation of ntcA expression and nitrite uptake in the marine Synechococcus sp. strain WH 7803. D Lindell E Padan AF Post, J Bacteriol 1998 180 1878 1886 9537388
19. Microcystin-producing blooms-a serious global public health issue. DR de Figueiredo UM Azeiteiro SM Esteves F Goncalves MJ Pereira, Ecotoxicol Environ Safety 2004 59 151 163 10.1016/j.ecoenv.2004.04.006 15327870
20. Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: An integrated peptide-polyketide synthetase system. D Tillett E Dittmann M Erhard H von Döhren T Börner BA Neilan, Chem Biol 2000 7 753 764 10.1016/S1074-5521(00)00021-1 11033079
21. Light and the transcriptional response of the microcystin biosynthesis gene cluster. M Kaebernick BA Neilan T Börner E Dittmann, Appl Environ Microbiol 2000 66 3387 3392 10.1128/AEM.66.8.3387-3392.2000 10919796
22. Multiple alternate transcripts direct the biosynthesis of microcystin, a cyanobacterial nonribosomal peptide. M Kaebernick E Dittmann T Börner BA Neilan, Appl Environ Microbiol 2002 68 449 455 10.1128/AEM.68.2.449-455.2002 11823177
23. Iron availability affects mcyD expression and microcystin-LR synthesis in Microcystis aeruginosa PCC7806. E Sevilla B Martin-Luna L Vela MT Bes MF Fillat ML Peleato, Env Microbiol 2008 10 2476 2483 10.1111/j.1462-2920.2008.01663.x
24. Fur from Microcystis aeruginosa binds in vitro promoter regions of the microcystin biosynthesis gene cluster. B Martin-Luna E Sevilla JA Hernandez MT Bes MF Fillat ML Peleato, Phytochem 2006 67 876 881 10.1016/j.phytochem.2006.02. 005
25. Detection of microcystin-metal complexes by using cryospray ionization-Fourier transform ion cyclotron resonance mass spectrometry. K Saito Y Sei S Miki K Yamaguchi, Toxicon 2008 51 1496 1498 10.1016/j.toxicon.2008.03. 026 18468650
26. Towards clarification of the biological role of microcystins, a family of cyanobacterial toxins. D Schatz Y Keren A Vardi A Sukenik S Carmeli T Börner E Dittmann A Kaplan, Environ Microbiol 2007 9 965 970 10.1111/j.1462-2920.2006.01218.x 17359268
27. Regulation of secondary metabolism in Streptomycetes. MJ Bibb, Curr Op Microbiol 2005 8 208 215 10.1016/j.mib.2005.02.016 (Pubitemid 40417964)
28. Essential structure of E. coli promoter: Effect of spacer length between the two consensus sequences on promoter function. T Aoyama M Takanami E Ohtsuka Y Taniyama R Marumoto H Sato M Ikehara, Nuc Acids Res 1983 11 5855 5864 10.1093/nar/11.17.5855
29. Compilation and analysis of Escherichia coli promoter DNA sequences. DK Hawley WR McClure, Nuc Acids Res 1983 11 2237 2255 10.1093/nar/11.8.2237
30. Compilation of E. coli mRNA promoter sequences. S Lisser H Margalit, Nuc Acid Res 1993 21 1507 1516 10.1093/nar/21.7.1507
31. InsPecT: Identification of posttranslationally modified peptides from tandem mass spectra. S Tanner H Shu A Frank L-C Wang E Zandi M Mumby PA Pevzner V Bafna, Anal Chem 2005 77 4626 4639 10.1021/ac050102d 16013882
32. A phosphorylated DNA-binding protein is specific for the red-light signal during complementary chromatic adaptation in cyanobacteria. A Sobczyk A Bely N Tandeau de Marsac J Houmard, Mol Microbiol 1994 13 875 885 10.1111/j.1365-2958. 1994.tb00479.x 7815945
33. Promoter recognition by a cyanobacterial RNA polymerase: In vitro studies with the Calothrix sp. PCC 7601 transcriptional factors RcaA and RcaD. G Schyns L Jia T Coursin N Tandeau de Marsac J Houmard, Plant Mol Biol 1998 36 649 659 10.1023/A:1005983320006 9526497
34. Co-ordinated expression of phycobiliprotein operons in the chromatically adapting cyanobacterium Calothrix PCC 7601: a role for RcaD and RcaG. S Noubir I Luque JAG Ochoa de Alda I Perewoska N Tandeau de Marsac JG Cobley J Houmard, Mol Microbiol 2002 43 749 762 10.1046/j.1365-2958.2002.02783.x 11929529
35. Responding to color: The regulation of complementary chromatic adaptation. DM Kehoe A Gutu, Ann Rev Plant Biol 2006 57 127 150 10.1146/annurev.arplant.57.032905.105215 (Pubitemid 44061021)
36. Inverse transcriptional activities during complementary chromatic adaptation are controlled by the response regulator RcaC binding to red and green light-responsive promoters. L Li RM Alvey RP Bezy DM Kehoe, Mol Microbiol 2008 68 286 297 10.1111/j.1365-2958.2008.06151.x 18346116
37. Enhancer activity of light-responsive regulatory elements in the untranslated leader regions of cyanobacterial psbA genes. R Li SS Golden, Proc Natl Acad Sci USA 1993 90 11678 11682 10.1073/pnas.90.24.11678 8265608
38. Roles of multiple promoters in transcription of ribosomal DNA: Effects of growth conditions on precursor rRNA synthesis in mycobacteria. JA Gonzalez-y-Merchand MJ Colston RA Cox, J Bacteriol 1998 180 5756 5761 9791129
39. Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula. AV Ramaswamy CM Sorrels WH Gerwick, J Nat Prod 2007 70 1977 1986 10.1021/np0704250 18001088
40. Cyanobacterial RNA polymerase genes rpoC1 and rpoC2 correspond to rpoC of Escherichia coli. WQ Xie K Jager M Potts, J Bacteriol 1989 171 1967 1973 2495268
41. The 5'-upstream cis-acting sequences of a cyanobacterial psbA gene: Analysis of their roles in basal, light-dependent and circadian transcription. J Shibato GK Agrawal H Kato M Asayama M Shirai, Mol Genet Genom 2002 267 684 694 10.1007/s00438-002-0704-3 (Pubitemid 34824198)
42. Specific recognition of the cyanobacterial psbA promoter by RNA polymerases containing principal sigma factors. J Shibato M Asayama M Shirai, Biochim Biophys Acta 1998 1442 296 303 9804976
43. Two-component regulatory proteins ResD-ResE are required for transcriptional activation of fnr upon oxygen limitation in Bacillus subtilis. MM Nakano P Zuber P Glaser A Danchin FM Hulett, J Bacteriol 1996 178 3796 3802 8682783
44. Translation initiation of cyanobacterial rbcS mRNAs requires the 38-kDa ribosomal protein S1 but not the Shine-Dalgarno sequence: Development of a cyanobacterial in vitro translation system. M Mutsuda M Sugiura, J Biol Chem 2006 281 38314 38321 10.1074/jbc.M604647200 17046824
45. Leaderless mRNAs in bacteria: Surprises in ribosomal recruitment and translational control. I Moll S Grill CO Gualerzi U Blasi, Mol Microbiol 2002 43 239 246 10.1046/j.1365-2958.2002.02739.x 11849551
46. The regulation of bacterial transcription initiation. DF Browning SJW Busby, Nat Rev Microbiol 2004 2 57 65 10.1038/nrmicro787 15035009
47. The regulator protein PyrR of Bacillus subtilis specifically interacts in vivo with three untranslated regions within pyr mRNA of pyrimidine biosynthesis. B Hobl M Mack, Microbiol 2007 153 693 700 10.1099/mic.0.2006/ 003772-0 (Pubitemid 46444367)
48. Structure of curacin A, a novel antimitotic, antiproliferative, and brine shrimp toxic natural product from the marine cyanbacterium Lyngbya majuscula. WH Gerwick PJ Proteau DG Nagle E Hamel A Blokhin DL Slate, J Org Chem 1994 59 1243 1245 10.1021/jo00085a006
49. Chromatic adaptation in marine Synechococcus strains. B Palenik, Appl Environ Microbiol 2001 67 991 994 10.1128/AEM.67.2.991-994.2001 11157276
50. Genomic DNA Microarray Analysis: Identification of new genes regulated by light color in the cyanobacterium Fremyella diplosiphon. EL Stowe-Evans J Ford DM Kehoe, J Bacteriol 2004 186 4338 4349 10.1128/JB.186.13.4338-4349.2004 15205436
51. Metamorphic enzyme assembly in polyketide diversification. L Gu B Wang A Kulkarni TW Geders RV Grindberg L Gerwick K Håkansson P Wipf JL Smith WH Gerwick DH Sherman, Nature 2009 459 731 735 10.1038/nature07870 19494914
52. Identification of differential gene expression in bacteria associated with coral black band disease by using RNA-arbitrarily primed PCR. J Frias-Lopez GT Bonheyo BW Fouke, Appl Environ Microbiol 2004 70 3687 3694 10.1128/AEM.70.6.3687-3694.2004 15184174
53. Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56. S Rachid K Gerth I Kochems R Müller, Mol Microbiol 2007 63 1783 1796 10.1111/j.1365-2958.2007.05627.x 17367395