Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 1, Issue 1, 2009, Pages 48-56

  Kumasaka, Debra K ^a   Galvan, Veronica ^b   Head, Elizabeth ^c   Rohn, Troy T ^a  

^a BOISE STATE UNIVERSITY   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyloid precursor protein; Apoptosis; Bcl 2; Beta amyloid; Caspase; Mouse model; Neurofibrillary tangles; Plaques; Tau

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CASPASE 3; PROTEIN BCL 2;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; SUBICULUM;

EID: 74549174287     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Chun W and Johnson GV. The role of tau phosphorylation and cleavage in neuronal cell death. Front Biosci 2007; 12: 733-756.
2. Golde TE, Dickson D and Hutton M. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Curr Alzheimer Res 2006; 3: 421-430.
3. Rohn TT, Rissman RA, Davis MC, Kim Y-E, Cotman C and Head E. Caspase-9 Activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis 2002; 11: 341-354.
4. Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI and Cryns VL. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A 2003; 100: 10032-10037.
5. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT and Cotman CW. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest 2004; 114: 121-130.
6. Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA and Bredesen DE. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A 2006; 103: 7130-7135.
7. Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J and Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci 2008; 28: 862-867.
8. Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA and Head E. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci 2008; 28: 3051-3059.
9. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y and LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003; 39: 409-421.
10. Martinou J-C, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C and Huarte J. Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 1994; 13: 1017-1030.
11. Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S and Nicholson DW. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloidbeta precursor protein and amyloidogenic A beta peptide formation. Cell 1999; 97: 395-406.
12. Hou ST, Jiang SX, Desbois A, Huang D, Kelly J, Tessier L, Karchewski L and Kappler J. Calpaincleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia. J Neurosci 2006; 26: 2241-2249.
13. Bian GL, Wei LC, Shi M, Wang YQ, Cao R and Chen LW. Fluoro-Jade C can specifically stain the degenerative neurons in the substantia nigra of the 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine-treated C57BL/6 mice. Brain Res 2007; 1150: 55-61.
14. Mouser PE, Head E, Ha KH and Rohn TT. Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. Am J Pathol 2006; 168: 936-946.
15. Su JH, Kesslak JP, Head E and Cotman CW. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol (Berl) 2002; 104: 1-6.
16. Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo EH and Bredesen DE. Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem 2002; 82: 283-294.
17. Oddo S, Caccamo A, Smith IF, Green KN and LaFerla FM. A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol 2006; 168: 184-194.
18. Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH and Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid beta- protein precursor. Nat Med 2000; 6: 397-404.
19. Zhao M, Su J, Head E and Cotman CW. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis 2003; 14: 391-403.
20. Wilquet V and De Strooper B. Amyloid-beta precursor protein processing in neurodegeneration. Curr Opin Neurobiol 2004; 14: 582-588.
21. Lu DC, Soriano S, Bredesen DE and Koo EH. Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem 2003; 87: 733-741.
22. Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH and Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med 2000; 6: 397-404.
23. Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE and Koo EH. A{beta} induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). Faseb J 2006;
24. Danial NN. BCL-2 family proteins: critical checkpoints of apoptotic cell death. Clin Cancer Res 2007; 13: 7254-7263.
25. Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW and Tanzi RE. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 2007; 54: 721-737.