Do nutritional markers in wound fluid reflect pressure ulcer status?

Wound Repair and Regeneration

Volumn 18, Issue 1, 2010, Pages 31-37

  Iizaka, Shinji ^a   Sanada, Hiromi ^a   Minematsu, Takeo ^a   Oba, Miho ^b   Nakagami, Gojiro ^a   Koyanagi, Hiroe ^c   Nagase, Takashi ^a   Konya, Chizuko ^d   Sugama, Junko ^d  

^a UNIVERSITY OF TOKYO   (Japan)

^b INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^c UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; GLUCOSE; HYDROXYPROLINE; PROTEIN; ZINC;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DECUBITUS; FEMALE; GLUCOSE BLOOD LEVEL; GRANULATION TISSUE; HUMAN; MALE; NUTRITIONAL STATUS; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; WOUND FLUID; WOUND HEALING; WOUND INFECTION; ZINC BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ALBUMINS; ANTIBODIES, ANTI-IDIOTYPIC; BIOLOGICAL MARKERS; EXUDATES AND TRANSUDATES; FEMALE; GLUCOSE; GRANULATION TISSUE; HUMANS; HYDROXYPROLINE; MALE; MIDDLE AGED; NUTRITIONAL STATUS; PRESSURE ULCER; PROTEINS; WOUND HEALING; WOUND INFECTION; ZINC;

EID: 74549158221     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2009.00564.x     Document Type: Article

References (27)

1. European pressure ulcer advisory panel pressure ulcer treatment guidelines. Oxford : European Pressure Ulcer Advisory Panel, 1998., Available at :. Accessed December 4, 2008.
2. Horn SD, Bender SA, Bergstrom N, Cook AS, Ferguson ML, Rimmasch HL, Sharkey SS, Smout RJ, Taler GA, Voss AC. Description of the national pressure ulcer long-term care study. J Am Geriatr Soc 2002 50 : 1816 1825.
3. Keelaghan E, Margolis D, Zhan M, Baumgarten M. Prevalence of pressure ulcers on hospital admission among nursing home residents transferred to the hospital. Wound Repair Regen 2008 16 : 331 336.
4. Bolton L, McNees P, van Rijswijk L, de Leon J, Lyder C, Kobza L, Edman K, Scheurich A, Shannon R, Toth M. Wound-healing outcomes using standardized assessment and care in clinical practice. J Wound Ostomy Continence Nurs 2004 31 : 65 71.
5. Bennett G, Dealey C, Posnett J. The cost of pressure ulcers in the UK. Age Ageing 2004 33 : 230 235.
6. Sibbald RG, Williamson D, Orsted HL, Campbell K, Keast D, Krasner D, Sibbald D. Preparing the wound bed-debridement, bacterial balance, and moisture balance. Ostomy Wound Manage 2000 46 : 14 35.
7. Whitney J, Phillips L, Aslam R, Barbul A, Gottrup F, Gould L, Robson MC, Rodeheaver G, Thomas D, Stotts N. Guidelines for the treatment of pressure ulcers. Wound Repair Regen 2006 14 : 663 679.
8. Schultz GS, Sibbald RG, Falanga V, Ayello EA, Dowsett C, Harding K, Romanelli M, Stacey MC, Teot L, Vanscheidt W. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen 2003 11 (1 Suppl.) : 1S 28S.
9. World Union of Wound Healing Societies. Principles of exudates: wound exudate and the role of dressings. A consensus document. London : MEP Ltd, 2007.
10. Ladwig GP, Robson MC, Liu R, Kuhn MA, Muir DF, Schultz GS. Ratios of activated matrix metalloproteinase-9 to tissue inhibitor of matrix metalloproteinase-1 in wound fluids are inversely correlated with healing of pressure ulcers. Wound Repair Regen 2002 10 : 26 37.
11. Williams JZ, Abumrad N, Barbul A. Effect of a specialized amino acid mixture on human collagen deposition. Ann Surg 2002 3 : 369 375.
12. Mouës CM, van Toorenenbergen AW, Heule F, Hop WC, Hovius SE. The role of topical negative pressure in wound repair: expression of biochemical markers in wound fluid during wound healing. Wound Repair Regen 2008 16 : 488 494.
13. Konya C, Sanada H, Sugama J, Kitayama Y, Ishikawa S, Togashi H, Tamura S. Skin debris and micro-organisms on the periwound skin of pressure ulcers and the influence of periwound cleansing on microbial flora. Ostomy Wound Manage 2005 51 : 50 9.
14. James TJ, Hughes MA, Cherry GW, Taylor RP. Simple biochemical markers to assess chronic wounds. Wound Repair Regen 2000 8 : 264 269.
15. Trengove NJ, Langton S, Stacey M. Biochemical analysis of wound fluid from nonhealing and healing chronic leg ulcers. Wound Repair Regen 1996 4 : 234 239.
16. Sanada H, Moriguchi T, Miyachi Y, Ohura T, Nakajo T, Tokunaga K, Fukui M, Sugama J, Kitagawa A. Reliability and validity of DESIGN, a tool that classifies pressure ulcer severity and monitors healing. J Wound Care 2004 13 : 13 8.
17. Sundararajan V, Henderson T, Perry C, Muggivan A, Quan H, Ghali WA. New ICD-10 version of the Charlson Comorbidity Index predicted in-hospital mortality. J Clin Epidemiol 2004 57 : 1288 1294.
18. Gardner SE, Frantz RA, Doebbeling BN. The validity of the clinical signs and symptoms used to identify localized chronic wound infection. Wound Repair Regen 2001 9 : 178 186.
19. O'Meara S, Nelson EA, Golder S, Dalton JE, Craig D, Iglesias C. Systematic review of methods to diagnose infection in foot ulcers in diabetes. Diabet Med 2006 23 : 341 347.
20. Stotts NA, Rodeheaver GT, Thomas DR, Frantz RA, Bartolucci AA, Sussman C, Ferrell BA, Cuddigan J, Maklebust J. An instrument to measure healing in pressure ulcers: development and validation of the pressure ulcer scale for healing (PUSH). J Gerontol A Biol Sci Med Sci 2001 56 : 795 799.
21. Honda H, Qureshi AR, Heimbürger O, Barany P, Wang K, Pecoits-Filho R, Stenvinkel P, Lindholm B. Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD. Am J Kidney Dis 2006 47 : 139 148.
22. Broughton G II., Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg 2006 117 (7 Suppl.) : 12S 34S.
23. Trengove NJ, Bielefeldt-Ohmann H, Stacey MC. Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Wound Repair Regen 2000 8 : 13 25.
24. White RJ, Cutting KF. Critical colonization - the concept under scrutiny. Ostomy Wound Manage 2006 52 : 50 6.
25. Lin HI, Chu SJ, Perng WC, Wu CP, Lin ZY, Huang KL. Hyperbaric oxygen attenuates cell growth in skin fibroblasts cultured in a high-glucose medium. Wound Repair Regen 2008 16 : 513 519.
26. Kaplan B, Gönül B, Dinçer S, Dinçer Kaya FN, Babül A. Relationships between tensile strength, ascorbic acid, hydroxyproline, and zinc levels of rabbit full-thickness incision wound healing. Surg Today 2004 34 : 747 751.
27. Ågren MS. Collagen synthesis in connective tissue of wounded rat mesentery: effect of dietary zinc deficiency. Eur J Surg 1991 157 : 453 455.