Lactic acidosis associated with metformin in a patient with type 2 diabetes with no contraindication

Endocrinologist

Volumn 19, Issue 6, 2009, Pages 250-

  Dora, José Miguel ^a   De Souza, Lívia H ^a   De Azevedo, Mirela J ^a   Gross, Jorge L ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Biguanides; Lactic acidosis; Metformin; Type 2 diabetes

Indexed keywords

ACETYLSALICYLIC ACID; ENALAPRIL; GLIBENCLAMIDE; HYPERTENSIVE FACTOR; ISOPHANE INSULIN; METFORMIN; SIMVASTATIN;

ADULT; ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; CLINICAL FEATURE; CONTINUOUS HEMODIALYSIS; HOSPITAL DISCHARGE; HUMAN; LABORATORY TEST; LACTIC ACIDOSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PACEMAKER; RESPIRATORY FAILURE; TREATMENT OUTCOME;

EID: 74549151078     PISSN: 10512144     EISSN: None     Source Type: Journal    
DOI: 10.1097/TEN.0b013e3181bf1e2e     Document Type: Article

References (6)

1. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive bloodglucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352:854-865.
2. Salpeter S, Greyber E, Pasternak G, et al. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev. 2006:CD002967.
3. Misbin RI, Green L, Stadel BV, et al. Lactic acidosis in patients with diabetes treated with metformin. N Engl J Med. 1998;338:265-266.
4. Cryer DR, Nicholas SP, Henry DH, et al. Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study. Diabetes Care. 2005;28:539-543.
5. Holstein A, Stumvoll M. Contraindications can damage your health-is metformin a case in point? Diabetologia. 2005 48:2454-2459.
6. Eurich DT, Majumdar SR, McAlister FA, et al. Improved clinical outcomes associated with metformin in patients with diabetes and heart failure. Diabetes Care. 2005;28:2345-2351.