Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications

Journal of Analytical Toxicology

Volumn 33, Issue 9, 2009, Pages 604-609

  Björnstad, Kristian ^a   Helander, Anders ^a   Hultén, Peter ^b   Beck, Olof ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Swedish Poisons Information Center   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2,4,5 TRIMETHOXYAMPHETAMINE; 2,4,5 TRIMETHOXYCINNAMIC ACID; ALPHA ASARONE; AMPHETAMINE DERIVATIVE; BETA ASARONE; CINNAMIC ACID DERIVATIVE; OIL; UNCLASSIFIED DRUG;

ACORUS CALAMUS; ADOLESCENT; ADULT; ARTICLE; BIOTRANSFORMATION; CLINICAL ARTICLE; CUNNINGHAMELLA ELEGANS; FEMALE; HUMAN; INTOXICATION; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; NAUSEA; TACHYCARDIA; TANDEM MASS SPECTROMETRY; URINE LEVEL; VOMITING;

ACORUS CALAMUS; CUNNINGHAMELLA ELEGANS; FUNGI; MAMMALIA;

EID: 74549139705     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/33.9.604     Document Type: Article

References (22)

1. C. Rätsch. The Encyclopedia of Psychoactive Plants. Park Street Press, Rochester, VT, 2005.
2. S.B. Vohora, S.A. Shah, and P.C. Dandiya. Central nervous system studies on an ethanol extract of Acorus calamus rhizomes. J Ethnopharmacol. 28: 53-62 (1990).
3. C. Deng, S. Lin, T. Huang, G. Duan, and X. Zhang. Development of gas chromatography/mass spectrometry following headspace solid-phase microextraction for fast determination of asarones in plasma. Rapid Commun. Mass Spectrom. 20: 2120-2126 (2006).
4. G. Hasheminejad and J. Caldwell. Genotoxicity of the alkenylbenzenes alpha- and beta-asarone, myristicin and elimicin as determined by the UDS assay in cultured rat hepatocytes. Food Chem. Toxicol. 32: 223-231 (1994).
5. 3H/HeJ F1 mice. Cancer Res. 47: 2275-2283 (1987).
6. Scientific Committee on Food. Opinion of the scientific committee on food on the presence of beta-asarone in flavourings and other food ingredients with flavouring properties. European Commission - Health & Consumer Protection Directorate, Bruxelles, Belgium, 2002.
7. A. Hoffer and H. Osmond. The Hallucinogens. Academic Press, New York, NY, 1967, p 626.
8. C.E. Dennehy, C. Tsourounis, and A.E. Miller. Evaluation of herbal dietary supplements marketed on the internet for recreational use. Ann. Pharmacother. 39: 1634-1639 (2005).
9. A.H. Ewald, G. Fritschi, and H.H. Maurer. Designer drug 2,4,5-trimethoxyamphetamine (TMA-2): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques. J. Mass Spectrom. 41: 1140-1148 (2006).
10. J. Beyer, D. Ehlers, and H.H. Maurer. Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry. Ther. Drug Monit. 28: 568-575 (2006).
11. A. Tevell, C. Olsson, U. Bondesson, and M. Hedeland. Identification of drug metabolites produced by the fungus Cunninghamella elegans using liquid chromatography/tandem mass spectrometry. In: 16th International Conference of Racing Analysts and Veterinarians, Tokyo, Japan, 2006.
12. J.D. Moody, J.P. Freeman, and C.E. Cerniglia. Biotransformation of doxepin by Cunninghamella elegans. Drug Metab. Dispos. 27: 1157-1164 (1999).
13. V. Lander and P. Schreier. Light-induced transformation of asarone. Flavour Fragrance J. 6: 21-28 (1991).
14. H.E. Persson, G.K. Sjöberg, J.A. Haines, and J. Pronczuk de Garbino. Poisoning severity score. Grading of acute poisoning. J. Toxicol. Clin. Toxicol. 36: 205-213 (1998).
15. K. Björnstad, O. Beck, and A. Helander. A multi-component LC-MS-MS method for detection of ten plant-derived psychoactive substances in urine. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877: 1162-1168 (2009).
16. K. Björnstad, P. Hulten, O. Beck, and A. Helander. Bioanalytical and clinical evaluation of 103 suspected cases of intoxications with psychoactive plant materials. Clin. Toxicol. 47: 566-572 (2009).
17. C.P. Vargas, L.R. Wolf, S.R. Gamm, and K. Koontz. Getting to the root (Acorus calamus) of the problem. J. Toxicol. Clin. Toxicol. 36: 259-260 (1998).
18. J. Ott. Pharmacotheon-Entheogenic Drugs, Their Plant Sources and History, 1st ed. Natural Products Co., Kennewick, WA, 1993.
19. R.E. Scultes. The botanical and chemical distribution of hallucinogens. Annu. Rev. Plant. Physiol. 21: 571-598 (1970).
20. J. Antunez-Solis, F. Hernandez-Derramadero, M. Aquino-Vega, S. Ibarra-Ramirez, L. Rodriguez-Paez, I. Baeza, and C. Wong. 2,4,5- trimethoxycinnamic acid: the major metabolite of alpha-asarone, retains most of the pharmacological properties of alpha-asarone. J. Enzyme Inhib. Med. Chem. 24: 903-909 (2009).
21. D.C. McMillan, P.P. Fu, and C.E. Cerniglia. Stereoselective fungal metabolism of 7,12-dimethylbenz[a]anthracene: identification and enantiomeric resolution of a K-region dihydrodiol. Appl. Environ. Microbiol. 53: 2560-2566 (1987).
22. S.N. Sivaswamy, B. Balachandran, S. Balanehru, and V.M. Sivaramakrishnan. Mutagenic activity of south Indian food items. Indian J. Exp. Biol. 29: 730-737 (1991).