Dietary L-arginine supplementation improves intestinal function in weaned pigs after an Escherichia coli lipopolysaccharide challenge

Asian-Australasian Journal of Animal Sciences

Volumn 22, Issue 12, 2009, Pages 1667-1675

  Liu, Yulan ^a,b   Han, Jie ^b   Huang, Jingjing ^b   Wang, Xiaoqiu ^a   Wang, Fenglai ^a   Wang, Junjun ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b WUHAN POLYTECHNIC UNIVERSITY   (China)

Author keywords

Arginine; Intestinal function; Lipopolysaccharide; Weaned pigs

Indexed keywords

ESCHERICHIA COLI; SUIDAE;

EID: 74549135679     PISSN: 10112367     EISSN: None     Source Type: Journal    
DOI: 10.5713/ajas.2009.90100     Document Type: Article

References (45)

1. AOAC. 1990. Official methods of analysis (15th Ed.). Association of Official Analytical Chemists, Washington, DC
2. Chander, V. and K. Chopra. 2005. Renal protective effect of molsidomine and L-arginine in ischemia-reperfusion induced injury in rats. J. Surg. Res. 128:132-139.
3. 56k and protein synthesis in piglet rotavirus enteritis. J. Nutr. 138:24-29.
4. Fang, Y. Z., S. Yang and G Y Wu. 2002. Free radicals, antioxidants, and nutrition. Nutrition 18:872-879.
5. Fink, M. P., J. B. Antonsson, H. L. Wang and H. R. Rothschild. 1991. Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. Arch. Surg. 126:211-218.
6. Fotiadis, C, S. Adamis, E. P. Misiakos, M. Genetzakis, P. T. Antonakis, D. K. Tsekouras, V. G Gorgoulis, G C. Zografos, A. Papalois, M. Fotinou and D. Perrea. 2007. The prophylactic effect of L-arginine in acute ischaemic colitis in a rat model of ischaemia/reperfusion injury. Acta Chir. Belg. 107:192-200.
7. Gao, C. J., W Chai, L. X. Xu, G H. Zhang, H. Zhang, L. C. Han and X. D. Sun. 2006. Protective effects of hyperoxygenated solution preconditioning on intestinal ischemia-reperfusion injury in rabbits. J. Surg. Res. 135:268-274.
8. Gurbuz, A. T, J. Kunzelman and E. E. Ratzer. 1998. Supplemental dietary arginine accelerates intestinal mucosal regeneration and enhances bacterial clearance following radiation enteritis in rats. J. Surg. Res. 74:149-154.
9. Hampson, D. J. and D. E. Kidder. 1986. Influence of creep feeding and weaning on brush border enzyme activities in the piglet small intestine. Res. Vet. Sci. 40:24-31.
10. Han, J., Y L. Liu, W. Fan, J. Chao, Y. Q. Hou, Y. L. Yin, H. L. Zhu, G Q. Meng and Z. Q. Che. 2008. Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs. Amino Acids 10.1007/s00726-008-0184-9.
11. Hou, Y Q., Y L. Liu, J. Hu and W. H. Shen. 2006. Effects of lactitol and tributyrin on growth performance, small intestinal morphology and enzyme activity in weaned pigs. Asian-Aust. J. Anim. Sci. 19:1470-1477.
12. Kobayashi, H., T. Nonami, T. Kurokawa, Y Takeuchi, A. Harada, A. Nakao and H. Takagi. 1995. Role of endogenous nitric oxide in ischemia-reperfusion injury in rat liver. J. Surg. Res. 59:772-779.
13. Kohli, R., C. J. Meininger, T. E. Haynes, W. Yan, J. T. Self and G Wu. 2004. Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J. Nutr. 134:600-608.
14. Kruzel, M. L., Y Harari, C. Y Chen and G A. Castro. 2000. Lactoferrin protects gut mucosal integrity during endotoxemia induced by lipopolysaccharide in mice. Inflammation 24:33-44.
15. Liu, G P., W. P. Zhou, W. X. Zhu, G M. Cheng, S. J. Jiang and S. G He. 2003. The protective effect of L-arginine on the intestine barrier of rats with obstructive jaundice. J. Hepatobiliary Surg. 11:153-154 (Chinese).
16. Liu, K. X., T. Rinne, W. He, F. Wang and Z. Y Xia. 2007. Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat. Can. J. Anesth. 54:366-374.
17. Liu, Y, H. Liu and Q. Y Kong. 2005. The roles of superoxide dismutase, nitric oxide synthase and nitric oxide in the antitumor mechanism of arsenic trioxide. Acta Acad. Med. Xuzhou. 25:8-12.
18. Liu, Y L., J. J. Huang, Y Q. Hou, H. L. Zhu, S. J. Zhao, B. Y Ding, Y L. Yin, G F. Yi, J. X. Shi and W. Fan. 2008a. Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs. Br. J. Nutr. 100:552-560.
19. Liu, Y L., J. Lu, J. X. Shi, Y Q. Hou, H. L. Zhu, S. J. Zhao, H. M. Liu, B. Y Ding, Y. L. Yin and G F. Yi. 2008b. Increased expression of the peroxisome proliferator-activated receptor γ in the immune system of weaned pigs after Escherichia coli lipopolysaccharide challenge. Vet. Immunol. Immunopathol. 124:82-92.
20. Lowry, O. H., N. J. Rosebrough, A. L. Farr and R. J. Randall. 1951. Protein measurement with folin phenol reagent. J. Biol. Chem. 193:265-275.
21. Mansoori, B., H. Nodeh, M. Modirsanei, S. Rahbari and P. Aparnak. 2009. d-Xylose absorption test: A tool for the assessment of the effect of anticoccidials on the intestinal absorptive capacity of broilers during experimental coccidiosis. Anim. Feed Sci. Technol. 148:301-308.
22. Mercer, D. W, G S. Smith, J. M. Cross, D. H. Russell, L. Chang and J. Cacioppo. 1996. Effects of lipopolysaccharide on intestinal injury: potential role of nitric oxide and lipid peroxidation. J. Surg. Res. 63:185-192.
23. Miguez, I., G Mariño, B. Rodriguez and C. Taboada. 2004. Effects of dietary L-arginine supplementation on serum lipids and intestinal enzyme activities in diabetic rats. J. Physiol. Biochem. 60:31-37.
24. NRC. 1998. Nutrient requirements of swine (10th Ed.). National Academic Press, Washington, DC.
25. Orlando, G F., G Wolf and M. Engelmann. 2008. Role of neuronal nitric oxide synthase in the regulation of the neuroendocrine stress response in rodents: insights from mutant mice. Amino Acids 35:17-27.
26. Peng, X., H. Yan, Z. Y. You, P. Wang and S. L. Wang. 2004. Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients. Burns 30:135-139.
27. Rhoden, E. L., L. Pereira-Lima, C. R. Rhoden, M. L. Lucas, C. Telöken and A. Belló-Klein. 2001. Role of the L-arginine/nitric oxide pathway in renal ischaemia-reperfusion in rats. Eur. J. Surg. 167:224-228.
28. Schleiffer, R. and F. Raul. 1996. Prophylactic administration of L-arginine improves the intestinal barrier function after mesenteric ischaemia. Gut 39:194-198.
29. Semrad, S. D. 2005. Malassimilation syndromes in large animals. In: Merck veterinary manual, ninth ed. (Ed. C. M. Kahn). Merck Co. Inc., Whitehouse Station, NJ, USA. pp. 301-306.
30. Spanos, C. P., P. Papaconstantinou, P. Spanos, M. Karamouzis, G Lekkas and C. Papaconstantinou. 2007. The effect of L-arginine and aprotinin on intestinal ischemia-reperfusion injury. J. Gastrointest. Surg. 11:247-255.
31. Sukhotnik, I., J. Mogilner, M. M. Krausz, M. Lurie, M. Hirsh, A. G Coran and E. Shiloni. 2004. Oral arginine reduces gut mucosal injury caused by lipopolysaccharide endotoxemia in rat. J. Surg. Res. 122:256-262.
32. Sukhotnik, I., H. Helou, J. Mogilner, M. Lurie, A. Bernsteyn, A. G Coran and E. Shiloni. 2005. Oral arginine improves intestinal recovery following ischemia-reperfusion injury in rat. Pediatr. Surg. Int. 21:191-196.
33. Verdonk, J. M. A. J., M. A. M. Spreeuwenberg, G C. M. Bakker and M. W. A. Verstegen. 2001. Nutrient intake level affects histology and permeability of the small intestine in newly weaned piglets. In Digestive physiology of pigs (Ed. J. E. Lindberg and B. Ogle), pp. 332-334. Wallingford, UK: CABI Publishing.
34. Wang, J. J., L. X. Chen, D. F. Li, Y. L. Yin, X. Q. Wang, P. Li, L. J. Dangott, W. X. Hu and G Y. Wu. 2008a. Intrauterine growth restriction affects the proteomes of the small intestine, liver, and skeletal muscle in newborn pigs. J. Nutr. 138:60-66.
35. Wang, J. J., L. X. Chen, P. Li, X. L. Li, H. J. Zhou, F. L. Wang, D. F. Li, Y. L. Yin and G Y. Wu. 2008b. Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation. J. Nutr. 138:1025-1032.
36. Wang, W. W., S. Y. Qiao and D. F. Li. 2009. Amino acids and gut function. Amino Acids 37:105-110.
37. Wu, G, F. W Bazer, T. A. Cudd, W S. Jobgen, S. W. Kim, A. Lassala, P. Li, J. H. Matis, C. J. Meininger and T. E. Spencer. 2007a. Pharmacokinetics and safety of arginine supplementation in animals. J. Nutr. I37:1673S-1680S.
38. Wu, G, F. W Bazer, T. A. Davis, L. A. Jaeger, G A. Johnson, S. W. Kim, D. A. Knabe, C. J. Meininger, T. E. Spencer and Y. L. Yin. 2007b. Important roles for the arginine family of amino acids in swine nutrition and production. Livest. Sci. 112:8-22.
39. Wu, G, D. A. Knabe and S. W. Kim. 2004. Arginine nutrition in neonatal pigs. J. Nutr. 134:2783S-2390S.
40. Wu, G, C. J. Meininger, D. A. Knabe, F. W. Bazer and J. M. Rhoads. 2000. Arginine nutrition in development, health and disease. Curr. Opin. Clin. Nutr. Metab. Care 3:59-66.
41. Yao, K., Y. L. Yin, W. Y. Chu, Z. Q. Liu, D. Deng, T. J. Li, R. L. Huang, J. S. Zhang, B. Tan, W. C. Wang and G Y. Wu. 2008. Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs. J. Nutr. 138:867-872.
42. Zhan, Z. F., D. Y Ou, X. S. Piao, S. W. Kim, Y. H. Liu and J. J. Wang. 2008. Dietary arginine supplementation affects microvascular development in the small intestine of earlyweaned pigs, J. Nutr. 138:1304-1309.
43. Zhang, C, Z. Y Sheng, S. Hu, J. C. Gao, S. Yu and Y. Liu. 2002. The influence of apoptosis of mucosal epithelial cells on intestinal barrier integrity after scald in rats. Burns 28:731-737.
44. Zhang, L. P., C. Y. Yang, Y. P. Wang, F. Cui and Y. Zhang. 2008. Protective effect of polydatin against ischemia/reperfusion injury in rat heart. Acta Physiologica Sinica 60:161-168.
45. Zheng, C. T, T. Wang, Z. N. Lu, S. G Zou, R. J. Xu and J. S. Zhang. 1999. EFfects of oral insulin and trypsinized formula milk on small intestinal growth and development in newborn pigs. Acta Veterinaria et Zootechnica Sinica. 30:405-413 (Chinese).