Designing appropriate clinical trials to assess ACEI use and cognitive decline in older adults with hypertension

Archives of Internal Medicine

Volumn 170, Issue 1, 2010, Pages 107-

  Todd, Stephen ^a   McGuinness, Bernadette ^a   Passmore, A Peter ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; DIHYDROPYRIDINE DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; INDAPAMIDE; NITRENDIPINE; PERINDOPRIL; POTASSIUM SPARING DIURETIC AGENT;

ALZHEIMER DISEASE; CLINICAL RESEARCH; CLINICAL TRIAL; COGNITIVE DEFECT; DEMENTIA; DRUG RESEARCH; DRUG USE; HUMAN; HYPERTENSION; LETTER; PRIORITY JOURNAL;

EID: 74549120780     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2009.463     Document Type: Letter

References (5)

1. Sink KM, Leng X, Williamson J, et al. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the cardiovascular health study. Arch Intern Med. 2009;169(13):1195- 1202.
2. Rozzini L, Chilovi BV, Bertoletti E, et al. Angiotensin converting enzyme (ACE) inhibitors modulate the rate of progression of amnestic mild cognitive impairment. Int J Geriatr Psychiatry. 2006;21(6):550-555.
3. McGuinness B, Todd S, Passmore P, Bullock R. The effects of blood pressure lowering on development of cognitive impairment and dementia in patients without apparent prior cerebrovascular disease. Cochrane Database Syst Rev. 2006;(2):CD004034.
4. Peters R, Beckett N, Forette F, et al; HYVET investigators. Incident dementia and blood pressure lowering in the hypertension in the very elderly trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol. 2008;7(8):683-689.
5. Saxby BK, Harrington F, McKeith IG, Wesnes K, Ford GA. Effects of hypertension on attention, memory, and executive function in older adults. Health Psychol. 2003;22(6):587-591.