Monitoring hepatitis C infection in a major Swedish nephrology unit and molecular resolution of a new case of nosocomial transmission

Journal of Medical Virology

Volumn 82, Issue 2, 2010, Pages 249-256

  Almroth, Gabriel ^a   Ekermo, Bengt ^a   Åkerlind, Britt ^a   Månsson, Ann Sofie ^b   Widell, Anders ^b  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Hemodialysis; Hepatitis C virus; Nosocomial transmission; NS5B; Phylogenetic analysis

Indexed keywords

NONSTRUCTURAL PROTEIN 5B; VIRUS RNA;

ACUTE KIDNEY FAILURE; ARTICLE; CONTROLLED STUDY; GENE CLUSTER; GENE SEQUENCE; GRAFT RECIPIENT; HEMODIALYSIS; HEMODIALYSIS PATIENT; HEPATITIS C; HEPATITIS C VIRUS; HOSPITAL INFECTION; HUMAN; INCIDENCE; INFECTION CONTROL; KIDNEY GRAFT; MAJOR CLINICAL STUDY; NONHUMAN; PERITONEAL DIALYSIS; PHYLOGENY; POLYMERASE CHAIN REACTION; VIRUS GENE; VIRUS STRAIN; VIRUS TRANSMISSION; WARD;

ANIMALS; CLUSTER ANALYSIS; CROSS INFECTION; FEMALE; HEMODIALYSIS UNITS, HOSPITAL; HEPACIVIRUS; HEPATITIS C; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PHYLOGENY; RENAL DIALYSIS; SEQUENCE ANALYSIS, DNA; SWEDEN; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 74549117135     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21683     Document Type: Article

References (29)

1. Abdel-Hamid M, El-Daly M, Molnegren V, El-Kafrawy S, Abdel-Latif S, Esmat G, Strickland GT, Loffredo C, Albert J, Widell A. 2007. Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma. J Gen Virol 88:1526-1531.
2. Alfurayh O, Sabeel A, Al Ahdal MN, Almeshari K, Kessie G, HamidM, Dela Cruz DM. 2000.Hand contamination with hepatitis C virus in staff looking after hepatitis C-positive hemodialysis patients. Am J Nephrol 20:103.
3. Allander T, Medin C, Jacobsson SH, Grillner L, Persson MA. 1994. Hepatitis C transmission in a hemodialysis unit: Molecular evidence for spread of virus among patients not sharing equipment. J Med Virol 43:415-419.
4. Almroth G, Ekermo B, Mansson AS, Svensson G, Widell A. 2002. Detection and prevention of hepatitis C in dialysis patients and renal transplant recipients. A long-term follow up (1989-January 1997). J Int Med 251:119-128.
5. Almroth G, Uhlin F, Ekermo B, Isaksson B, Kaijser B, Andersson B, Hahn-Zoric M, Sallberg M. 2003. Perspectives on hepatitis B infections and the efficacy of vaccination (hepatitis B and pneumococci) in dialysis patients. Ups J Med Sci 108:61-74.
6. Caramelo C, Bartolome J, Albalate M, de Sequera P, Navas S, Bermejillo T, Oliva H, Marriott E, Ortiz A, RuizTunon C, Casado S, Carreno V. 1996. Undiagnosed hepatitis C virus infection in hemodialysis patients: Value of HCV RNA and liver enzyme levels. Kidney Int 50:2027-2031.
7. Castillo I, Pardo M, Bartolomé J, Ortiz-Movilla N, Rodriguez-Inigo E, de Lucas S, SalasC, Jiménez-Heffernan JA, Pérez-Mota A, Graus J, López-Alcorocho JM, Carreno V. 2004. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Infect Dis 189:7-14.
8. Cendoroglo Neto M, Draibe SA, Silva AE, Ferraz ML, Granato C, Pereira CA, Sesso RC, Gaspar AM, Ajzen H. 1995. Incidence of and risk factors for hepatitis B virus and hepatitis C virus infection among haemodialysis and CAPD patients: Evidence for environmental transmission. Nephrol Dial Transplant 10:240-246.
9. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:362-364.
10. Delarocque-Astagneau E, Baffoy N, Thiers V, Simon N, de Valk H, Laperche S, Courouce AM, Astagneau P, Buisson C, Desenclos JC. 2002. Outbreak of hepatitisCvirus infection in a hemodialysis unit: Potential transmission by the hemodialysis machine? Infect Control Hosp Epidemiol 23:328-334.
11. Dzekova-Vidimliski P, Asani A, Selim G, Gelev S, Polenakovic M, Sikole A. 2008. Patterns of viraemia in haemodialysis patients with hepatitis C. Prilozi 29:201-211.
12. Eknoyan G, Lameire N. 2008. KDIGO clinical practice guidelines for the prevention, diagnosis, evaluation and treatment of hepatitis C in chronic kidney disease. Kidney Int 73:46-52, 53-68.
13. Fabrizi F, Martin P, Dixit V, Brezina M, Cole MJ, Vinson S, Mousa M, Gitnick G. 2000. Biological dynamics of viral load in haemodialysis patients with hepatitis C virus. Am J Kidney Dis 35:122-129.
14. Foberg U, Ekermo B, Widell A, Mathiesen U, Fryden A. 1996.Hepatitis C virus transmission, 1988-1991, via blood components from donors subsequently found to be anti-HCV-positive. Scand J Infect Dis 28:21-26.
15. Ghafur A, Raza M, Labbett W, Chawla A, Smith C, Ngui SL, Davenport A, Geretti AM. 2007. Travel-associated acquisition of hepatitis C virus infection in patients receiving haemodialysis. Nephrol Dial Transplant 22:2640-2644.
16. Hinrichsen H, Leimenstoll G, Stegen G, Schrader H, Folsch UR, Schmidt WE. 2002. Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: A multicentre study in 2796 patients. Gut 51:429-433.
17. Jadoul M, Cornu C, van Ypersele de Strihou C. 1998. Universal precautions prevent hepatitis C virus transmission: A 54-month follow up of the Belgian multicenter study. The Universitaires Cliniques St-Luc (UCL) Colloborative Group. Kidney Int 53:1022-1025.
18. Kallinowski B, Theilmann L, Gmelin K, Andrassy K, Depperman D, Weinel B, Kommerell B. 1991. Prevalence of antibodies to hepatitis C virus in haemodialysis patients. Nephron 59:236-238.
19. Kamar N, Nicot F, Izopet J, Rostaing L. 2009. Occult hepatitis C virus infection in hemodialysis patients: Examining the evidence. Am J Kidney Dis 54:10-12.
20. Lagging LM, Aneman C, Nenonen N, Brandberg A, Grip L, Norkrans G, Lindh M. 2002. Nosocomial transmission of HCV in a cardiology ward during the window phase of infection: An epidemiological and molecular investigation. Scand J Infect Dis 34:580-582.
21. Le Pogam S, Le Chapois D, Christen R, Dubois F, Barin F, Goudeau A. 1998. Hepatitis C in a haemodialysis unit: Molecular evidence for nosocomial transmission. J Clin Microbiol 36:3040-3043.
22. Löve A, Molnegren V, Ma° nsson AS, Smaradottir A, Thorsteinsson SB, Widell A. 2004. Evolution of hepatitis C virus variants following blood transfusion from one infected donor to several recipients: A long-term follow-up. J Gen Virol 85:441-450.
23. Milotic I, Pavic I, Maleta I, Troselj-Vukic B, Milotic F. 2002. Modified range of alanine aminotransferase is insufficient for screening of hepatitis C virus infection in hemodialysis patients. Scand J Urol Nephrol 36:447-449.
24. Noiri E, Nakao A, Oya A, Fujita T, Kimura S. 2001. Hepatitis C virus in blood and dialysate in hemodialysis. Am J Kidney Dis 37:38-42.
25. Norder H, Bergstrom A, Uhnoo I, Alden J, Weiss L, Czajkowski J, Magnius L. 1998. Confirmation of nosocomial transmission of hepatitis C virus by phylogenetic analysis of the NS5-B region. J Clin Microbiol 36:3066-3069.
26. Savey A, Simon F, Izopet J, Lepoutre A, Fabry J, Desenclos JC. 2005. A large nosocomial outbreak of hepatitis C virus infections at a hemodialysis center. Infect Control Hosp Epidemiol 26:752-760.
27. Soffredini R, Rumi M, Lampertico P, Aroldi A, Tarantino A, Ponticelli C, Colombo M. 1996. Increased detection of antibody to hepatitis C virus in renal transplant patients by third generation assays. Am J Kidney Dis 28:437-440.
28. Widell A, Shev S, Mansson S, Zhang YY, Foberg U, NorkransG, Fryden A, Weiland O, Kurkus J, Nordenfelt E. 1994. Genotyping of hepatitis C virus isolates by a modified polymerase chain reaction assay using type specific primers: Epidemiological applications. J Med Virol 44:272-279.
29. Widell A, Christensson B, Wiebe T, Schalén C, Hansson HB, Allander T, Persson MA. 1999. Epidemiologic and molecular investigation of outbreaks of hepatitis C virus infection on a pediatric oncology service. Ann Intern Med 130:130-134.